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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xbp1tm2Glm
targeted mutation 2, Laurie H Glimcher
MGI:3774017
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atg16l1tm1Kuv/Atg16l1tm1Kuv
Tg(Vil1-cre)997Gum/0
Xbp1tm2Glm/Xbp1tm2Glm 		B6.Cg-Atg16l1tm1Kuv Xbp1tm2Glm Tg(Vil1-cre)997Gum MGI:6296755
cn2
 		Xbp1tm2Glm/Xbp1tm2Glm
Tg(Adipoq-rtTA)2Zvw/0
Tg(tetO-cre)1Jaw/0 		involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6N MGI:6376195
cn3
 		Ern1tm2.1Tiw/Ern1tm2.1Tiw
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * SJL MGI:5559520
cn4
 		Xbp1tm2Glm/Xbp1tm2Glm
Tg(Defa6-icre)1Rsb/0 		involves: 129S6/SvEvTac * C57BL/6 MGI:5559515
cn5
 		Atg7tm1Tchi/Atg7tm1Tchi
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Defa6-icre)1Rsb/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5559516
cn6
 		Xbp1tm2Glm/Xbp1tm2Glm
Tg(Mx1-cre)1Cgn/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3811310
cn7
 		Atg7tm1Tchi/Atg7tm1Tchi
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL MGI:5559519
cn8
 		Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:5559518
cn9
 		Xbp1tm2Glm/Xbp1+
Tg(Vil1-cre)997Gum/0 		involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL MGI:5441533
cn10
 		Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0 		involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL MGI:5441532
cn11
 		Atg16l1tm1Kuv/Atg16l1tm1Kuv
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5559514
cn12
 		Xbp1tm2Glm/Xbp1tm2Glm
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Vil1-cre)997Gum/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5559521
cn13
 		Xbp1tm2Glm/Xbp1tm2Glm
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3811309
cn14
 		Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5559517


Genotype
MGI:6296755
cn1
Allelic
Composition		 Atg16l1tm1Kuv/Atg16l1tm1Kuv
Tg(Vil1-cre)997Gum/0
Xbp1tm2Glm/Xbp1tm2Glm
Genetic
Background		 B6.Cg-Atg16l1tm1Kuv Xbp1tm2Glm Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1tm1Kuv mutation (1 available); any Atg16l1 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased enterocyte apoptosis ( J:269933 )
• in the ileum of mice exacerbated by IL22 treatment
small intestinal inflammation ( J:269933 )
• in the ileum of mice exacerbated by IL22 treatment

immune system
small intestinal inflammation ( J:269933 )
• in the ileum of mice exacerbated by IL22 treatment

cellular
increased enterocyte apoptosis ( J:269933 )
• in the ileum of mice exacerbated by IL22 treatment




Genotype
MGI:6376195
cn2
Allelic
Composition		 Xbp1tm2Glm/Xbp1tm2Glm
Tg(Adipoq-rtTA)2Zvw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Adipoq-rtTA)2Zvw mutation (1 available)
Tg(tetO-cre)1Jaw mutation (5 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal nucleotide metabolism ( J:260830 )
• the 24 hour fasting-induced increase in plasma uridine that is seen in wild-type mice is reduced in doxycycline (Dox)-treated mutant mice
• however, mice do not show a reduced lipolysis response to the Beta3 adrenergic receptor agonist CL316,243

adipose tissue
increased body fat mass ( J:260830 )
• mice that are switched to a Dox high-fat diet at 69 weeks of age show a higher fat mass than controls 4 weeks after the diet switch
• however, Dox-treated mice fed a high-fat diet do not show a difference in body weight gain from wild-type mice fed the same diet

growth/size/body
increased body fat mass ( J:260830 )
• mice that are switched to a Dox high-fat diet at 69 weeks of age show a higher fat mass than controls 4 weeks after the diet switch
• however, Dox-treated mice fed a high-fat diet do not show a difference in body weight gain from wild-type mice fed the same diet




Genotype
MGI:5559520
cn3
Allelic
Composition		 Ern1tm2.1Tiw/Ern1tm2.1Tiw
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern1tm2.1Tiw mutation (1 available); any Ern1 mutation (57 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:206084 )
• enteritis is diminished compared to mice with IEC (intestinal epithelial cell) deletion of Xbp1 only

digestive/alimentary system
small intestinal inflammation ( J:206084 )
• enteritis is diminished compared to mice with IEC (intestinal epithelial cell) deletion of Xbp1 only




Genotype
MGI:5559515
cn4
Allelic
Composition		 Xbp1tm2Glm/Xbp1tm2Glm
Tg(Defa6-icre)1Rsb/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Defa6-icre)1Rsb mutation (0 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:206084 )
• >75% of animals develop spontaneous enteritis with Xbp1 deletion in Paneth cells, having features similar to mice with Xbp1 deletion in IECs (intestinal epithelial cells)

digestive/alimentary system
abnormal Paneth cell morphology ( J:206084 )
• defects in granule morphology are observed
• increased cell death in crypts is observed compare to Xbp1 deletion in IECs (intestinal epithelial cells)
small intestinal inflammation ( J:206084 )
• >75% of animals develop spontaneous enteritis with Xbp1 deletion in Paneth cells, having features similar to mice with Xbp1 deletion in IECs (intestinal epithelial cells)

endocrine/exocrine glands
abnormal Paneth cell morphology ( J:206084 )
• defects in granule morphology are observed
• increased cell death in crypts is observed compare to Xbp1 deletion in IECs (intestinal epithelial cells)

cellular
abnormal autophagy ( J:206084 )
• autophagy is induced in enterocytes in Paneth cells

homeostasis/metabolism
abnormal autophagy ( J:206084 )
• autophagy is induced in enterocytes in Paneth cells




Genotype
MGI:5559516
cn5
Allelic
Composition		 Atg7tm1Tchi/Atg7tm1Tchi
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Defa6-icre)1Rsb/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Tg(Defa6-icre)1Rsb mutation (0 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:206084 )
• mice show transmural inflammation as early as 8 weeks of age

digestive/alimentary system
small intestinal inflammation ( J:206084 )
• mice show transmural inflammation as early as 8 weeks of age




Genotype
MGI:3811310
cn6
Allelic
Composition		 Xbp1tm2Glm/Xbp1tm2Glm
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mx1-cre)1Cgn mutation (7 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid homeostasis ( J:137188 )
• induced mice exhibit impaired triglyceride secretion from the liver, and significantly decreased de novo lipid (fatty acids and sterols) synthesis in the liver
decreased circulating triglyceride level ( J:137188 )
• at 3 weeks after cre induction with poly(I:C), plasma triglyceride levels are lower than in wild-type
decreased cholesterol level ( J:137188 )
• at 3 weeks after cre induction with poly(I:C), an almost complete absence of LDL-associated cholesterol in primary hepatocytes
decreased fatty acids level ( J:137188 )
• at 3 weeks after cre induction with poly(I:C), free fatty acid levels in isolated hepatocytes are reduced compared to wild-type controls




Genotype
MGI:5559519
cn7
Allelic
Composition		 Atg7tm1Tchi/Atg7tm1Tchi
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
intestinal inflammation ( J:206084 )
• with Atg7 and Xbp1 deletion in IECs (intestinal epithelial cells), most mice (>70%) develop discontinuous or transmural inflammation with acute and chronic inflammation ending in an abrupt fashion to muscularis propria and serosa resembling pathologies seen in human patients with Crohn's disease
• enteritis progresses such that it is present in all animals by 18 weeks
• dextran sodium sulfate treatment induces greater inflammation that in wild-type mice
ileum inflammation ( J:206084 )
• ileitis is more severe than in animals with IEC deletion of Xbp1 only

cellular

digestive/alimentary system
abnormal enterocyte physiology ( J:206084 )
• intestinal epithelial cells (IECs) completely lack unfolded protein response (UPR)-induced autophagy
• more apoptotic IEC cells are detected than in mice having only Xbp1 deletion in IECs
intestinal inflammation ( J:206084 )
• with Atg7 and Xbp1 deletion in IECs (intestinal epithelial cells), most mice (>70%) develop discontinuous or transmural inflammation with acute and chronic inflammation ending in an abrupt fashion to muscularis propria and serosa resembling pathologies seen in human patients with Crohn's disease
• enteritis progresses such that it is present in all animals by 18 weeks
• dextran sodium sulfate treatment induces greater inflammation that in wild-type mice
ileum inflammation ( J:206084 )
• ileitis is more severe than in animals with IEC deletion of Xbp1 only

homeostasis/metabolism




Genotype
MGI:5559518
cn8
Allelic
Composition		 Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:206084 )
• treatment of mice with rapamycin reduces severity of enteritis

digestive/alimentary system
abnormal enterocyte physiology ( J:206084 )
• intenstinal epithelial cells exhibit ER (endoplamic reticulum) stress by 3 days after tamoxifen treatment
small intestinal inflammation ( J:206084 )
• treatment of mice with rapamycin reduces severity of enteritis

cellular
abnormal autophagy ( J:206084 )
• autophagy is induced in enterocytes, most notably in Paneth cells by 3 days after tamoxifen treatment
• treatment of mice with rapamycin induces autophagy in Paneth cells

homeostasis/metabolism
abnormal autophagy ( J:206084 )
• autophagy is induced in enterocytes, most notably in Paneth cells by 3 days after tamoxifen treatment
• treatment of mice with rapamycin induces autophagy in Paneth cells




Genotype
MGI:5441533
cn9
Allelic
Composition		 Xbp1tm2Glm/Xbp1+
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
small intestinal inflammation ( J:188627 )
• mild in 5 of 16 mice

immune system
small intestinal inflammation ( J:188627 )
• mild in 5 of 16 mice




Genotype
MGI:5441532
cn10
Allelic
Composition		 Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
rectal hemorrhage ( J:188627 )
• in DSS-treated mice
abnormal small intestine goblet cell morphology ( J:188627 )
• reduced number and size in the small intestine with reduced secretory granules
absent Paneth cells ( J:188627 )
• absent with barely detectable lysozyme and pro-forms of cryptdin stores
intestinal ulcer ( J:188627 )
• in some mice
abnormal intestine physiology ( J:188627 )
• mice exhibit an increase in the migration rate of proliferating cells in the crypt-villus compared with control mice
increased susceptibility to induced colitis ( J:188627 )
• mice treated with DSS exhibit more severe wasting and rectal bleeding and increased areas of mucosal erosions, edema and cellular infiltration compared with control mice
• however, antibiotic treatment rescues increased sensitivity
small intestinal inflammation ( J:188627 )
• small intestine inflammation with endoplasmic reticulum stress in 19 of 31 mice
• inflammation is patchy and ranges in severity from lamina propria polymorphpnuclear infiltration to crypt abscesses and ulceration without granulomas
• however, mice do not exhibit reduced villus length

immune system
increased susceptibility to induced colitis ( J:188627 )
• mice treated with DSS exhibit more severe wasting and rectal bleeding and increased areas of mucosal erosions, edema and cellular infiltration compared with control mice
• however, antibiotic treatment rescues increased sensitivity
small intestinal inflammation ( J:188627 )
• small intestine inflammation with endoplasmic reticulum stress in 19 of 31 mice
• inflammation is patchy and ranges in severity from lamina propria polymorphpnuclear infiltration to crypt abscesses and ulceration without granulomas
• however, mice do not exhibit reduced villus length
increased susceptibility to bacterial infection ( J:188627 )
• mice infected with Listeria monocytogenes exhibit increased bacterial burden in the feces and liver compared with control mice
• however, bacterial burden in the spleen is normal

cardiovascular system
rectal hemorrhage ( J:188627 )
• in DSS-treated mice

cellular
abnormal small intestine goblet cell morphology ( J:188627 )
• reduced number and size in the small intestine with reduced secretory granules
abnormal endoplasmic reticulum morphology ( J:188627 )
• small intestine inflammation with endoplasmic reticulum stress in 19 of 31 mice
abnormal cell migration ( J:188627 )
• mice exhibit an increase in the migration rate of proliferating cells in the crypt-villus compared with control mice

growth/size/body
cachexia ( J:188627 )
• in DSS-treated mice

endocrine/exocrine glands
absent Paneth cells ( J:188627 )
• absent with barely detectable lysozyme and pro-forms of cryptdin stores

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
inflammatory bowel disease DOID:0050589 OMIM:PS266600
 J:188627




Genotype
MGI:5559514
cn11
Allelic
Composition		 Atg16l1tm1Kuv/Atg16l1tm1Kuv
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1tm1Kuv mutation (1 available); any Atg16l1 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal enterocyte physiology ( J:206084 )
• intestinal epithelial cells (IECs) completely lack unfolded protein response (UPR)-induced autophagy
• more apoptotic IEC cells are detected than in mice having only Xbp1 deletion in IECs
ileum inflammation ( J:206084 )
• with Atg16l1 and Xbp1 deletion in IECs, most mice (>70%) develop discontinuous or transmural inflammation by 18 weeks, with similar features to IECs with Atg7/Xbp1 deletion

immune system
ileum inflammation ( J:206084 )
• with Atg16l1 and Xbp1 deletion in IECs, most mice (>70%) develop discontinuous or transmural inflammation by 18 weeks, with similar features to IECs with Atg7/Xbp1 deletion




Genotype
MGI:5559521
cn12
Allelic
Composition		 Xbp1tm2Glm/Xbp1tm2Glm
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfrsf1atm1Imx mutation (6 available); any Tnfrsf1a mutation (47 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:206084 )
• enteritis is diminished compared to mice with IEC (intestinal epithelial cell) deletion of Xbp1 only

digestive/alimentary system
small intestinal inflammation ( J:206084 )
• enteritis is diminished compared to mice with IEC (intestinal epithelial cell) deletion of Xbp1 only




Genotype
MGI:3811309
cn13
Allelic
Composition		 Xbp1tm2Glm/Xbp1tm2Glm
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:131028 )
N
• after 139A prion infection, mice show similar survival time (159 days after birth) which is similar to controls (157 days)

nervous system
nervous system phenotype ( J:131028 )
N
• mice show no spontaneous neurological dysfunctions (tremors, gait or postural abnormalities, grip strength, paralysis, or body weight changes) between 10 and 22 weeks of age

behavior/neurological
behavior/neurological phenotype ( J:131028 )
N
• mice show no spontaneous neurological dysfunctions (tremors, gait or postural abnormalities, grip strength, paralysis, or body weight changes) between 10 and 22 weeks of age

immune system
decreased susceptibility to prion infection ( J:131028 )
• upon prion infection, animals do not exhibit increased neuronal apoptosis compared to uninfected mice




Genotype
MGI:5559517
cn14
Allelic
Composition		 Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:206084 )
• limited to the mucosa
• treatment of mice with rapamycin reduces severity of enteritis

digestive/alimentary system
abnormal enterocyte physiology ( J:206084 )
• intenstinal epithelial cells exhibit ER (endoplamic reticulum) stress
small intestinal inflammation ( J:206084 )
• limited to the mucosa
• treatment of mice with rapamycin reduces severity of enteritis

cellular
abnormal autophagy ( J:206084 )
• autophagy is induced in enterocytes, most notably in Paneth cells

homeostasis/metabolism
abnormal autophagy ( J:206084 )
• autophagy is induced in enterocytes, most notably in Paneth cells




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory