Atg16l1^tm1Kuv
Targeted Allele Detail

Summary

• Symbol: Atg16l1^tm1Kuv
• Name: autophagy related 16 like 1; targeted mutation 1, Universitat Kiel
• MGI ID: MGI:5559372
• Synonyms: Atg16l1^fl, Atg16l1^tm1.1Geno, NGF1 Flox
• Gene: Atg16l1 Location: Chr1:87683730-87720150 bp, + strand Genetic Position: Chr1, 44.44 cM
• Alliance: Atg16l1^tm1Kuv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206084
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP was inserted into the promoter region of Atg16l1, and a second loxP site and Frt-flanked neo cassette was placed in intron 1. Targeted mice were crossed to constitutive Flp expressing mice to remove the neo, leaving exon 1 floxed. (J:206084)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atg16l1 Mutation: 44 strains or lines available

References

• Original: J:206084 Adolph TE, et al., Paneth cells as a site of origin for intestinal inflammation. Nature. 2013 Nov 14;503(7475):272-6
• All: 10 reference(s)