All Phenotypes Atg16l1<tm1Kuv> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

increased enterocyte apoptosis ( J:269933 )

• in the ileum of DSS-treated mice exacerbated by IL22 treatment

• however, co-treatment with anti-IFNAR antibodies reduces the crypt region cell death under hard DSS treatment plus IL22

• organoid cell death induced by IFNbeta is amplified

increased susceptibility to induced colitis ( J:269933 )

• under a harsh DSS treatment regime, mice exhibit increased inflammatory regardless of anti-IFNAR treatment compared with control mice

• however, severity of colonic inflammation is not exacerbated by IL22 treatment

small intestinal inflammation ( J:269933 )

• under mild or harsh DSS treatment regimes, mice exhibit increased ileal inflammation exacerbated by IL22 treatment compared with control mice

• however, co-treatment with anti-IFNAR antibodies reduces the severity of small intestinal inflammation under hard DSS treatment plus IL22

growth/size/body

decreased body weight ( J:269933 )

• in mice treated with IL22 and DSS

immune system

increased susceptibility to induced colitis ( J:269933 )

• under a harsh DSS treatment regime, mice exhibit increased inflammatory regardless of anti-IFNAR treatment compared with control mice

• however, severity of colonic inflammation is not exacerbated by IL22 treatment

small intestinal inflammation ( J:269933 )

• under mild or harsh DSS treatment regimes, mice exhibit increased ileal inflammation exacerbated by IL22 treatment compared with control mice

• however, co-treatment with anti-IFNAR antibodies reduces the severity of small intestinal inflammation under hard DSS treatment plus IL22

cellular

increased enterocyte apoptosis ( J:269933 )

• in the ileum of DSS-treated mice exacerbated by IL22 treatment

• however, co-treatment with anti-IFNAR antibodies reduces the crypt region cell death under hard DSS treatment plus IL22

• organoid cell death induced by IFNbeta is amplified

Allelic Composition	Atg16l1^tm1Kuv/Atg16l1^tm1Kuv Tg(Vil1-cre)997Gum/0 Xbp1^tm2Glm/Xbp1^tm2Glm
Genetic Background	B6.Cg-Atg16l1^tm1Kuv Xbp1^tm2Glm Tg(Vil1-cre)997Gum

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1^tm1Kuv mutation (1 available); any Atg16l1 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Xbp1^tm2Glm mutation (0 available); any Xbp1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

increased enterocyte apoptosis ( J:269933 )

• in the ileum of mice exacerbated by IL22 treatment

small intestinal inflammation ( J:269933 )

• in the ileum of mice exacerbated by IL22 treatment

immune system

small intestinal inflammation ( J:269933 )

• in the ileum of mice exacerbated by IL22 treatment

cellular

increased enterocyte apoptosis ( J:269933 )

• in the ileum of mice exacerbated by IL22 treatment

Allelic Composition	Atg16l1^tm1Kuv/Atg16l1^tm1Kuv Xbp1^tm2Glm/Xbp1^tm2Glm Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal enterocyte physiology ( J:206084 )

• intestinal epithelial cells (IECs) completely lack unfolded protein response (UPR)-induced autophagy

• more apoptotic IEC cells are detected than in mice having only Xbp1 deletion in IECs

intestinal inflammation ( J:206084 )

ileum inflammation ( J:206084 )

• with Atg16l1 and Xbp1 deletion in IECs, most mice (>70%) develop discontinuous or transmural inflammation by 18 weeks, with similar features to IECs with Atg7/Xbp1 deletion

immune system

intestinal inflammation ( J:206084 )

ileum inflammation ( J:206084 )

• with Atg16l1 and Xbp1 deletion in IECs, most mice (>70%) develop discontinuous or transmural inflammation by 18 weeks, with similar features to IECs with Atg7/Xbp1 deletion

Allelic Composition	Atg16l1^tm1Kuv/Atg16l1^tm1Kuv Tg(Vil1-cre)997Gum/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1^tm1Kuv mutation (1 available); any Atg16l1 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal enterocyte morphology ( J:206084 )

• IECs (intestinal epithelial cells) have distended endoplasmic reticula, and reduced size and number of secretory granules

abnormal Paneth cell morphology ( J:206084 )

• cells display reduced overall size and number of secretory granules

abnormal enterocyte physiology ( J:206084 )

• IECs display loss of homeostatic autophagy

cellular

abnormal autophagy ( J:206084 )

• IECs (intestinal epithelial cells) display loss of homeostatic autophagy

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:206084 )

• cells display reduced overall size and number of secretory granules

homeostasis/metabolism

abnormal autophagy ( J:206084 )

• IECs (intestinal epithelial cells) display loss of homeostatic autophagy

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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