Tg(Adipoq-rtTA)2Zvw
Transgene Detail

Summary

• Symbol: Tg(Adipoq-rtTA)2Zvw
• Name: transgene inserion 2, Zhao Wang
• MGI ID: MGI:6306100
• Synonyms: Adiponectin-rtTA, adnP-rtTA, APN-rtTA
• Transgene: Tg(Adipoq-rtTA)2Zvw Location: unknown
• Alliance: Tg(Adipoq-rtTA)2Zvw page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The transgene was designed with an adiponection (Adipoq) promoter driving expression of the reverse tetracycline transactivator gene (rtTA). The 5.4 kb adiponectin promoter is comprised of 200 bp from the 5' end of the first intron linked to 200 bp from the 3' end of the first intron. The 3' end of the promoter is extended beyond the endogenous start codon ATG, which is mutated to ATA to facilitate correct translation initiation. (J:183541)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:183541 Sun K, et al., Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5874-9
• All: 15 reference(s)