Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Adipoq-rtTA)2Zvw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
Xbp1tm2Glm mutation
(0 available);
any
Xbp1 mutation
(28 available)
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homeostasis/metabolism
adipose tissue
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• mice that are switched to a Dox high-fat diet at 69 weeks of age show a higher fat mass than controls 4 weeks after the diet switch
• however, Dox-treated mice fed a high-fat diet do not show a difference in body weight gain from wild-type mice fed the same diet
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growth/size/body
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• mice that are switched to a Dox high-fat diet at 69 weeks of age show a higher fat mass than controls 4 weeks after the diet switch
• however, Dox-treated mice fed a high-fat diet do not show a difference in body weight gain from wild-type mice fed the same diet
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadtm1c(KOMP)Wtsi mutation
(0 available);
any
Cad mutation
(73 available)
Tg(Adipoq-rtTA)2Zvw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
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adipose tissue
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• mice show a moderate size reduction of adipocytes in subcutaneous white adipose tissue (sWAT) when fed a Dox-containing diet
• however, no differences in epididymal white adipose tissue (eWAT) or interscapular brown adipose tissue (BAT) adipocyte size is seen
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growth/size/body
N |
• mice do not show differences in bodyweight gain from wild-type mice when treated with doxycycline (Dox)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadtm1c(KOMP)Wtsi mutation
(0 available);
any
Cad mutation
(73 available)
Tg(Adipoq-rtTA)2Zvw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
Tg(tetO-Xbp1_is)#Pesch mutation
(0 available)
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growth/size/body
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• mice continue to increase their body weight when switched to a doxycycline (Dox)-containing diet, although not at the same extent as wild-type mice thus showing a partial reversal of weight loss
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adipose tissue
N |
• size of adipocytes is epididymal white adipose tissue (eWAT), subcutaneous white adipose tissue (sWAT), and in interscapular brown adipose tissue (BAT)is normal in Dox-treated mice
• adipose tissue uridine content is not increased and thus rescued in Dox-treated mice compared to Tg(tetO-Xbp1_is)#Pesch/0 Tg(Adipoq-rtTA)2Zvw/0 mice
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Adipoq-rtTA)2Zvw mutation
(1 available)
Tg(tetO-Xbp1_is)#Pesch mutation
(0 available)
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growth/size/body
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• weight loss in doxycycline (Dox)-treated mice is mainly due to a reduction of fat mass
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• mice start to lose body weight immediately upon switching to Dox-containing diet
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• Dox-treated mice fed a high-fat diet show a decrease in body weight and lower overall adiposity compared to wild-type mice
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homeostasis/metabolism
adipose tissue
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• weight loss in doxycycline (Dox)-treated mice is mainly due to a reduction of fat mass
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• smaller BAT weight in Dox-treated mice
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• adipocyte size is reduced in Dox-treated mice
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• Dox-treated mice exhibit less fibrosis and inflammation in eWAT at 40 weeks of age
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• smaller WAT weight in Dox-treated mice
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cellular
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• 6 days after the switch to Dox chow, fatty acid oxidation rates are elevated in sWAT
• 90 days after the switch to Dox chow, fatty acid oxidation rates are elevated in both sWAT and BAT
• however, lipid uptake rates are normal
• however, fatty acid or ketone bodies in circulation upon fasting are not affected in Dox-treated mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation
(5 available);
any
Lep mutation
(19 available)
Tg(Adipoq-rtTA)2Zvw mutation
(1 available)
Tg(tetO-Xbp1_is)#Pesch mutation
(0 available)
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growth/size/body
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• doxycycline (Dox)-treated mice fed a high-fat diet show a slower weight gain compared to single Lepob homozygous mice but do not show an actual net weight loss
• Dox-treated mice fed a high-fat diet show a reduction in fat mass gain compared to Lepob homozygous mice
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homeostasis/metabolism