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Dicer1 Gene Detail
Summary
  • Symbol
    Dicer1
  • Name
    dicer 1, ribonuclease type III
  • Synonyms
    1110006F08Rik, D12Ertd7e, Dicer1, mKIAA0928
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177178
    NCBI Gene: 192119
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104654001-104718211 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 54.83 cM, cytoband E-F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1466 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177178
 protein coding gene Chr12:104654001-104718331 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020079
 protein coding gene Chr12:106496586-106561133 (-)
A/J MGP_AJ_G0020033
 protein coding gene Chr12:102453746-102520501 (-)
AKR/J MGP_AKRJ_G0020010
 protein coding gene Chr12:105411127-105476562 (-)
BALB/cJ MGP_BALBcJ_G0020019
 protein coding gene Chr12:102862598-102913660 (-)
C3H/HeJ MGP_C3HHeJ_G0019822
 protein coding gene Chr12:105870605-105936175 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020465
 protein coding gene Chr12:109808783-109872324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018078
 protein coding gene Chr12:99163374-99228140 (-)
CAST/EiJ MGP_CASTEiJ_G0019363
 protein coding gene Chr12:100702709-100770347 (-)
CBA/J MGP_CBAJ_G0019789
 protein coding gene Chr12:114037996-114101948 (-)
DBA/2J MGP_DBA2J_G0019906
 protein coding gene Chr12:102001067-102065037 (-)
FVB/NJ MGP_FVBNJ_G0019891
 protein coding gene Chr12:100785871-100850157 (-)
LP/J MGP_LPJ_G0019981
 protein coding gene Chr12:106371106-106432700 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019929
 protein coding gene Chr12:117497185-117562274 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020494
 protein coding gene Chr12:104833855-104899065 (-)
PWK/PhJ MGP_PWKPhJ_G0019126
 protein coding gene Chr12:96507754-96573194 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018928
 protein coding gene Chr12:99101251-99167920 (-)
WSB/EiJ MGP_WSBEiJ_G0019422
 protein coding gene Chr12:105813587-105877693 (-)



Homology
more
  • Human Ortholog
    DICER1, dicer 1, ribonuclease III
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DICER1, dicer 1, ribonuclease III
  • Synonyms
    aviD, DCR1, Dicer, Dicer1e, GLOW, HERNA, K12H4.8-LIKE, MNG1, RMSE2
  • Links
    NCBI Gene ID: 23405
    neXtProt AC: NX_Q9UPY3
    UniProt: Q9UPY3

  • Chr Location
    14q32.13; chr14:95086228-95158010 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Dicer1 mouse models; 6 with human DICER1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    325 phenotypes from 21 alleles in 38 genetic backgrounds
    27 phenotypes from multigenic genotypes
    2 images
    418 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutation of this locus results in arrest of early embryonic development. Inducible muscle-specific KO results in impaired muscle regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    145
  • GO References
    48
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1163
  • Tissues
    195
  • cDNA Data
    168
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041415 Ensembl Gene Model | MGI Sequence Detail 64211 C57BL/6J ±  kb
    transcript ENSMUST00000041987 Ensembl | MGI Sequence Detail 9851 Not Applicable  
    polypeptide ENSMUSP00000043676 Ensembl | MGI Sequence Detail 1916 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 183
      cDNA 168
      Primer pair 12
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1098649, MGI:1915712
    References
    more
    • Summaries
      All 513
      Developmental Gene Expression 50
      Diseases 5
      Gene Ontology 48
      Phenotypes 418
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:354351 Wang L, et al., Schwann cell-derived exosomes ameliorate peripheral neuropathy induced by ablation of dicer in Schwann cells. Front Cell Neurosci. 2024;18:1462228
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory