Dicer1^tm1Smr
Targeted Allele Detail

Summary

• Symbol: Dicer1^tm1Smr
• Name: dicer 1, ribonuclease type III; targeted mutation 1, Sarah E Millar
• MGI ID: MGI:3641051
• Synonyms: Dicer^flEx22-23, Dicer^flox
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^tm1Smr page

Dilated cardiomyopathy in Dicer1^tm1Smr/Dicer1^tm1Smr Tg(Myh6-cre)2182Mds/0 hearts

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110268
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A floxed Dicer1 allele was created in a stem cell line (4E4) which contained a null Dicer1 allele, Dicer1^tm1Ghan. A Dicer1 allele with exons 22 and 23 flanked by loxP sites replaced the remaining wild-type Dicer1 allele in the ES cells. The resulting ES cells were used to create conditional mice homozygous for the floxed Dicer1 allele. (J:101186)

Generation of the Dicer1^tm1Smr allele

Disease models

Expression

In Mice Carrying this Mutation:	25 assay results 12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 94 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Glomerulocystic Disease J:229188.

References

• Original: J:110268 Andl T, et al., The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol. 2006 May 23;16(10):1041-9
• All: 49 reference(s)