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Prnp Gene Detail
Summary
  • Symbol
    Prnp
  • Name
    prion protein
  • Synonyms
    CD230, Prn-i, Prn-p, PrP, PrPC, PrPSc, Sinc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97769
    NCBI Gene: 19122
  • Member of
    Prn cluster
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131751848-131780349 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 64.07 cM
  • Mapping Data
    32 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97769
protein coding gene Chr2:131751848-131780356 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026534
protein coding gene Chr2:135469977-135491221 (+)
A/J MGP_AJ_G0026498
protein coding gene Chr2:129962230-129979230 (+)
AKR/J MGP_AKRJ_G0026473
protein coding gene Chr2:133697734-133716231 (+)
BALB/cJ MGP_BALBcJ_G0026510
protein coding gene Chr2:130355724-130371892 (+)
C3H/HeJ MGP_C3HHeJ_G0026253
protein coding gene Chr2:134165195-134182500 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026955
protein coding gene Chr2:139605133-139623767 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024332
protein coding gene Chr2:124695780-124711215 (+)
CAST/EiJ MGP_CASTEiJ_G0025714
protein coding gene Chr2:134475993-134492069 (+)
CBA/J MGP_CBAJ_G0026233
protein coding gene Chr2:144835556-144853798 (+)
DBA/2J MGP_DBA2J_G0026367
protein coding gene Chr2:129359331-129375791 (+)
FVB/NJ MGP_FVBNJ_G0026331
protein coding gene Chr2:127980253-127996094 (+)
LP/J MGP_LPJ_G0026472
protein coding gene Chr2:135683585-135701901 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026351
protein coding gene Chr2:148632524-148648025 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027010
protein coding gene Chr2:133680995-133699399 (+)
PWK/PhJ MGP_PWKPhJ_G0025450
protein coding gene Chr2:128941915-128957711 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025252
protein coding gene Chr2:132829794-132846846 (+)
WSB/EiJ MGP_WSBEiJ_G0025788
protein coding gene Chr2:134601444-134617851 (+)



Homology
more
  • Human Ortholog
    PRNP, prion protein (Kanno blood group)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRNP, prion protein (Kanno blood group)
  • Synonyms
    AltPrP, ASCR, CD230, CJD, GSS, KURU, p27-30, PRIP, PrP, PrP27-30, PrP33-35C, PrPc
  • Links
    NCBI Gene ID: 5621
    neXtProt AC: NX_F7VJQ1, NX_P04156
    UniProt: F7VJQ1, P04156

  • Chr Location
    20p13; chr20:4686350-4701590 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with Prnp mouse models; 5 with human PRNP associations

Human Disease Mouse Models
      
IDs
View 8 models
IDs
View 1 model
      
IDs
View 7 models
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    14 with disease annotations
  • References
    14 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 23 alleles in 14 genetic backgrounds
    99 phenotypes from multigenic genotypes
    9 images
    489 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations at this locus affect resistance to scrapie infection and spongiform encephalopathy and/or alter scrapie incubation time. Homozygous mutants also show impaired locomotor coordination and reduced mitochondria numbers with unusual morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079037 Ensembl Gene Model | MGI Sequence Detail 28502 C57BL/6J ±  kb
    transcript ENSMUST00000091288 Ensembl | MGI Sequence Detail 2184 Not Applicable  
    polypeptide ENSMUSP00000088833 Ensembl | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 13
      cDNA 38
      Primer pair 6
      Other 9

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13621, MGD-MRK-13622, MGD-MRK-14416, MGI:2138816, MGI:2138906, MGI:97768
    References
    more
    • Summaries
      All 748
      Developmental Gene Expression 23
      Diseases 14
      Gene Ontology 42
      Phenotypes 489
    • Earliest
      J:5082 Dickinson AG, et al., Identification of a gene which controls the incubation period of some strains of scrapie agent in mice. J Comp Pathol. 1968 Jul;78(3):293-9
    • Latest
      J:339412 Matamoros-Angles A, et al., Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability. BMC Biol. 2022 Jan 13;20(1):17

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory