Myc MGI Mouse Gene Detail - MGI:97250 - Myc proto-oncogene, bHLH transcription factor

Symbol

Myc
Name

Myc proto-oncogene, bHLH transcription factor
Synonyms

bHLHe39, c-myc, Myc2, Niard, Nird

Feature Type

protein coding gene
IDs

MGI:97250
NCBI Gene: 17869
Alliance

genome feature page
Transcription Start Sites

22 TSS
Regulated by

Rr357, Rr21, Rr356 ... (21 regulatory regions)

Sequence Map

Chr15:61857240-61862223 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 26.19 cM, cytoband D2-D3
Mapping Data

62 experiments

SNPs within 2kb

146 from dbSNP Build 142
Strain Annotations

19
PCR

5
RFLP

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97250	protein coding gene	Chr15:61857190-61862223 (+)
129S1/SvImJ	ENSMUSG00200028292	protein coding gene	Chr15:58889838-58894825 (+)
A/J	ENSMUSG00195006115	protein coding gene	Chr15:58918248-58923233 (+)
AKR/J	ENSMUSG00220020099	protein coding gene	Chr15:58828527-58833512 (+)
BALB/cJ	ENSMUSG00180008570	protein coding gene	Chr15:58827255-58832233 (+)
C3H/HeJ	ENSMUSG00175004718	protein coding gene	Chr15:59118622-59123599 (+)
C57BL/6NJ	ENSMUSG00215011538	protein coding gene	Chr15:58839286-58844273 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019833	protein coding gene	Chr15:56006532-56011549 (+)
CAST/EiJ	ENSTCUG00005006816	protein coding gene	Chr15:58670007-58674972 (+)
CBA/J	ENSMUSG00210007126	protein coding gene	Chr15:58950354-58955330 (+)
DBA/2J	ENSMUSG00185025345	protein coding gene	Chr15:58887975-58892958 (+)
FVB/NJ	ENSMUSG00205006445	protein coding gene	Chr15:58649284-58654271 (+)
JF1/MsJ	ENSUMUG00000020131	protein coding gene	Chr15:58656357-58661322 (+)
LP/J	ENSMUSG00230023955	protein coding gene	Chr15:62215413-62220396 (+)
NOD/ShiLtJ	ENSMUSG00190015621	protein coding gene	Chr15:59918981-59923962 (-)
NZO/HlLtJ	ENSMUSG00225026918	protein coding gene	Chr15:62495102-62500085 (+)
PWK/PhJ	ENSLUMG00010026265	protein coding gene	Chr15:58951275-58956233 (+)
SPRET/EiJ	ENSMSPG00010023790	protein coding gene	Chr15:60246109-60251081 (+)
WSB/EiJ	ENSIUOG00005006185	protein coding gene	Chr15:58935941-58940908 (+)

Human Ortholog

MYC, MYC proto-oncogene, bHLH transcription factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYC, MYC proto-oncogene, bHLH transcription factor
Synonyms

bHLHe39, c-Myc, MRTL, MYCC
Links

HGNC:7553

NCBI Gene ID: 4609

UniProt: P01106
Chr Location

8q24.21; chr8:127735434-127742951 (+) GRCh38

MGI Vertebrate Homology

Myc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYC
Protein SuperFamily

Myc_protein
Gene Tree

Myc

Diseases

5 with Myc mouse models; 9 with human MYC associations

Human Disease

Mouse Models

breast cancer

IDs

View 7 models

Burkitt lymphoma

IDs

View 4 models

autosomal dominant polycystic kidney disease

IDs

View 1 model

hepatocellular carcinoma

IDs

View 8 models

pancreatic carcinoma

IDs

View 3 models

acute promyelocytic leukemia

IDs

angiosarcoma

IDs

demyelinating disease

IDs

lung adenocarcinoma

IDs

prostate adenocarcinoma

IDs

prostate cancer

IDs

urinary bladder cancer

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

18 with disease annotations

References

22 with disease annotations

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Phenotype Summary

200 phenotypes from 42 alleles in 39 genetic backgrounds
143 phenotypes from multigenic genotypes
2 images
871 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

93
Chemically induced (other)

3
Endonuclease-mediated

11
Gene trapped

4
Radiation induced

2
Targeted

40
Transgenic

32
Transposon induced

1
Genomic Mutations

6 involving Myc
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters.

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All GO Annotations

177
GO References

49

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1562
Tissues

419
cDNA Data

88
Literature Summary

280

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MYC

Xenbase myc

ZFIN myca, mycb

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All Sequences

69
RefSeq

8
UniProt

5
CCDS

CCDS27504.1, CCDS49614.1, CCDS49615.1

Ensembl

ENSMUSG00000022346 (Evidence)
NCBI Gene

17869

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022346	Ensembl Gene Model \| MGI Sequence Detail	4984	C57BL/6J	± kb
transcript	ENSMUST00000022971	Ensembl \| MGI Sequence Detail	2338	Not Applicable
polypeptide	ENSMUSP00000022971	Ensembl \| MGI Sequence Detail	454	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000000084 c-myc protein

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR003327 Leucine zipper, Myc

IPR050433 Myc family transcription factors

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR002418 Transcription regulator Myc

IPR012682 Transcription regulator Myc, N-terminal
GlyGen

P01108 2 sites, 1 O-linked glycan (1 site)

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All nucleic 198

Genomic 46

cDNA 89

Primer pair 36

Other 27

Antibodies 16

Microarray probesets 3

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MGD-MRK-12736, MGI:2146128

Summaries

All 1682

Developmental Gene Expression 280

Diseases 22

Gene Ontology 49

Phenotypes 871
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:391646 Izzo LT, et al., KLF4 Promotes a KRT13+ Hillock-Like State in Lung Squamous Cell Carcinoma. Cancer Res. 2026 Jun 18;

Myc expression regulated by:

Feature	Feature Type	Location	Reference
Rr357, regulatory region 357	enhancer	Chr15:61317175-61317176	J:257088
Rr21, regulatory region 21	enhancer	Chr15:61490136-61491875	J:191217
Rr356, regulatory region 356	enhancer	Chr15:61661123-61661124	J:257088
Rr303293, regulatory region 303293	CTCF binding site	Chr15:61854801-61855400	J:257088
Rr311791, regulatory region 311791	promoter	Chr15:61855200-61861601	J:319454
Rr422, regulatory region 422	transcription factor binding site	Chr15:61855266-61855271	J:319454
Rr421, regulatory region 421	transcription factor binding site	Chr15:61856689-61856694	J:319454
Rr420, regulatory region 420	transcription factor binding site	Chr15:61856875-61856880	J:319454
Rr477, regulatory region 477	enhancer	Chr15:61880296-61886183	J:348281
Rr478, regulatory region 478	enhancer	Chr15:61964445-61967719	J:348281
Rr38, regulatory region 38	enhancer	Chr15:63127133-63128253	J:212391
Rr316124, regulatory region 316124	transcription factor binding site	Chr15:63482955-63483341	J:257739
Rr313933, regulatory region 313933	enhancer	Chr15:63488202-63489199	J:257739
Rr331, regulatory region 331	enhancer	Chr15:63519975-63520516	J:257739
Rr307328, regulatory region 307328	enhancer	Chr15:63529401-63531200	J:257739
Rr332, regulaory region 332	enhancer	Chr15:63537208-63537808	J:257739
Rr307330, regulatory region 307330	enhancer	Chr15:63550601-63552400	J:257739
Rr333, regulatory region 333	enhancer	Chr15:63576555-63577033	J:257739
Rr313939, regulatory region 313939	enhancer	Chr15:63580202-63582800	J:257739
Rr313944, regulatory region 313944	enhancer	Chr15:63607001-63610199	J:257739
Rr334, regulatory region 334	enhancer	Chr15, Syntenic	J:212391

TSS for Myc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131405	Chr15:61857226-61857246 (+)	-4 bp
Tssr131406	Chr15:61857389-61857405 (+)	157 bp
Tssr131407	Chr15:61858887-61858908 (+)	1,658 bp
Tssr131408	Chr15:61859153-61859167 (+)	1,920 bp
Tssr131409	Chr15:61859208-61859237 (+)	1,983 bp
Tssr131410	Chr15:61859259-61859340 (+)	2,060 bp
Tssr131411	Chr15:61859341-61859370 (+)	2,116 bp
Tssr131412	Chr15:61859457-61859472 (+)	2,225 bp
Tssr131413	Chr15:61859528-61859602 (+)	2,325 bp
Tssr131414	Chr15:61859640-61859649 (+)	2,405 bp
Tssr131415	Chr15:61859867-61859965 (+)	2,676 bp
Tssr131416	Chr15:61860013-61860022 (+)	2,778 bp
Tssr131417	Chr15:61860075-61860086 (+)	2,841 bp
Tssr131418	Chr15:61860093-61860100 (+)	2,857 bp
Tssr131419	Chr15:61860806-61860810 (+)	3,568 bp
Tssr131420	Chr15:61861241-61861254 (+)	4,008 bp
Tssr131421	Chr15:61861266-61861284 (+)	4,035 bp
Tssr131422	Chr15:61861290-61861303 (+)	4,057 bp
Tssr131423	Chr15:61861331-61861343 (+)	4,097 bp
Tssr131424	Chr15:61861405-61861416 (+)	4,171 bp
Tssr131425	Chr15:61861883-61861907 (+)	4,655 bp
Tssr131426	Chr15:61861953-61861958 (+)	4,716 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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