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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Shh
sonic hedgehog
MGI:98297
309 phenotypes from 16 alleles in 25 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Olig2tm1(cre)Tmj/Olig2+
Shhtm2Amc/Shhtm2Amc
involves: 129S1/Sv * 129X1/SvJ
abnormal spinal cord lateral motor column morphology J:277700
decreased motor neuron number J:277700
normal nervous system phenotype J:277700
Shhtm1(cre/ERT2)Tshim/Shhtm1(cre/ERT2)Tshim
Not Specified
no abnormal phenotype detected J:171106
Shhtm1(EGFP/cre)Cjt/Shhtm1(EGFP/cre)Cjt
Not Specified
abnormal atrium myocardium morphology J:204743
abnormal cystic duct morphology J:241569
abnormal gallbladder smooth muscle morphology J:241569
abnormal heart left atrium morphology J:204743
abnormal limb bone morphology J:92504
abnormal liver development J:241569
abnormal pulmonary artery morphology J:204743
abnormal respiratory conducting tube morphology J:204743
abnormal vascular smooth muscle morphology J:204743
abnormal vasculogenesis J:204743
absent pulmonary vein J:204743
acephaly J:241569
small gallbladder J:241569
Shhtm1(EGFP/cre)Cjt/Shhtm2Amc
involves: 129/Sv * C57BL/6J * SWR
abnormal neural tube morphology J:94270
cyclopia J:94270
Shhtm1.1Rseg/Shhtm1.1Rseg
involves: 129S4/SvJae * C57BL/6
abnormal cerebellum external granule cell layer morphology J:150524
abnormal embryonic/fetal subventricular zone morphology J:150524
abnormal postnatal subventricular zone morphology J:150524
cerebellum hypoplasia J:150524
decreased body weight J:150524
decreased brain weight J:150524
normal embryo phenotype J:150524
microphthalmia J:150524
small olfactory bulb J:150524
Shhtm1Ahk/Shhtm1Ahk
B6.Cg-Shhtm1Ahk
no abnormal phenotype detected J:188348
Shhtm1Ahk/Shhtm1Ahk
Slc6a3tm1(cre)Xz/Slc6a3+
involves: 129S1/Sv * C57BL/6
abnormal gait J:188348
abnormal synaptic dopamine release J:188348
decreased dopamine level J:188348
decreased locomotor activity J:188348
decreased neuron number J:188348
hindlimb paralysis J:188348
hyperactivity J:188348
increased dopamine level J:188348
increased neuron number J:188348
loss of dopaminergic neurons J:188348
premature death J:188348
Shhtm1Amc/Shhtm1.1Rseg
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
cerebellum hypoplasia J:150524
decreased body weight J:150524
decreased brain weight J:150524
normal embryo phenotype J:150524
microphthalmia J:150524
small olfactory bulb J:150524
Shhtm1Amc/Shhtm1Amc
involves: 129/Sv * C57BL/6J * CBA/J
abnormal colon morphology J:62158
abnormal dermal layer morphology J:50050
abnormal dermis papillary layer morphology J:50050
abnormal digestive organ placement J:62158
abnormal digestive system morphology J:62158
abnormal duodenum morphology J:62158
abnormal enteric neuron morphology J:62158
abnormal esophagus morphology J:62158
abnormal hair follicle development J:50050
abnormal hair follicle morphology J:50050
abnormal hair follicle orientation J:50050
abnormal hair shaft morphology J:50050
abnormal lung development J:50051
abnormal lung saccule morphology J:50051
abnormal lung vasculature morphology J:50051
abnormal small intestine morphology J:62158
abnormal smooth muscle morphology J:62158
abnormal stomach glandular epithelium morphology J:62158
abnormal tracheal cartilage morphology J:50051
abnormal tracheal smooth muscle morphology J:50051
absent hair follicle inner root sheath J:50050
absent hair follicles J:50050
alopecia J:50050
anal atresia J:62158
annular pancreas J:62158
decreased fetal size J:62158
decreased keratinocyte proliferation J:50051
epidermal hyperplasia J:50050
gastric metaplasia J:62158
impaired branching involved in bronchus morphogenesis J:50051
impaired lung lobe morphogenesis J:50051
perinatal lethality, complete penetrance J:50050
prenatal lethality, incomplete penetrance J:50050
pulmonary hypoplasia J:50051
stomach epithelial hyperplasia J:62158
thick epidermis J:50050
tracheoesophageal fistula J:50051
Shhtm1Amc/Shhtm1Amc
involves: 129S1/Sv * 129X1/SvJ
abnormal vertebrae morphology J:121553
holoprosencephaly J:121553
notochord degeneration J:121553
Shhtm1Amc/Shhtm1Amc
Not Specified
abnormal branching involved in lung morphogenesis J:91723
abnormal bronchus morphology J:91723
abnormal pharynx morphology J:91723
absent tracheal cartilage rings J:91723
neonatal lethality, complete penetrance J:91723
pulmonary hypoplasia J:91723
small stomach J:98520
tracheoesophageal fistula J:91723
Shhtm1Amc/Shhtm1Amc
STOCK Shhtm1Amc/J
abnormal submandibular gland morphology J:89200
Shhtm1Amc/Shhtm2Amc
involves: 129S1/Sv * 129X1/SvJ
no abnormal phenotype detected J:65294
Shhtm1Amc/Shhtm2Amc
Tg(Hoxb7-cre)13Amc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal kidney inner medulla morphology J:79481
abnormal kidney outer medulla inner stripe morphology J:79481
abnormal renal glomerulus morphology J:79481
abnormal ureter development J:79481
abnormal ureter smooth muscle morphology J:79481
decreased renal glomerulus number J:79481
hydronephrosis J:79481
hydroureter J:79481
kidney cortex hypoplasia J:79481
kidney medulla hypoplasia J:79481
renal hypoplasia J:79481
short ureter J:79481
small kidney J:79481
Shhtm1Amc/Shhtm2Amc
Tg(KRT14-cre)1Amc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal ameloblast morphology J:65294
abnormal cranium morphology J:65294
abnormal dentin morphology J:65294
abnormal enamel morphology J:65294
abnormal incisor morphology J:65294
abnormal lower incisor morphology J:65294
abnormal molar cusp morphology J:65294
abnormal nasal bone morphology J:65294
abnormal odontoblast morphology J:65294
abnormal palatal shelf fusion at midline J:90909
absent alveolar process J:65294
absent enamel cord J:65294
absent vibrissae J:65294
aerophagia J:65294
arrest of tooth development J:65294
cleft secondary palate J:90909
eyelids open at birth J:65294
growth retardation of incisors J:65294
growth retardation of molars J:65294
neonatal lethality, complete penetrance J:65294
palatal shelf hypoplasia J:90909
normal skeleton phenotype J:65294
small incisors J:65294
small molars J:65294
Shhtm1Amc/Shhtm2Amc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: FVB/N
abnormal branching involved in lung morphogenesis J:91723
abnormal bronchus morphology J:91723
abnormal lung morphology J:91723
abnormal trachea morphology J:91723
abnormal tracheal cartilage morphology J:91723
decreased tracheal cartilage ring number J:91723
lung cyst J:91723
neonatal lethality, complete penetrance J:91723
pulmonary hypoplasia J:91723
Shhtm1Amc/Shhtm2Amc
Tg(Thy1-cre)703Vaw/?
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
abnormal craniofacial morphology J:83530
abnormal eye development J:83530
abnormal eyelid morphology J:83530
abnormal glial cell morphology J:83530
abnormal optic nerve morphology J:83530
abnormal retina ganglion cell morphology J:83530
abnormal retina morphology J:78708
holoprosencephaly J:78708, J:83530
microcephaly J:83530
microphthalmia J:78708, J:83530
neonatal lethality, complete penetrance J:78708
Shhtm1b(EUCOMM)Wtsi/Shh+
C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H
decreased bone mineral content J:211773
decreased lean body mass J:211773
impaired glucose tolerance J:211773
increased circulating HDL cholesterol level J:211773
increased total body fat amount J:211773
Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H
preweaning lethality, complete penetrance J:211773
Shhtm1Chg/Shh+
Tg(Shh)#Dje/0
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
abnormal cerebellar granule layer morphology J:94461
abnormal cerebellum morphology J:94461
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ
abnormal axial skeleton morphology J:35802
abnormal craniofacial bone morphology J:35802
abnormal craniofacial morphology J:35802
abnormal dorsal-ventral axis patterning J:35802
abnormal forebrain morphology J:35802
abnormal foregut morphology J:35802
abnormal heart morphology J:35802
abnormal humerus morphology J:35802
abnormal kidney morphology J:35802
abnormal limb development J:159210
abnormal long bone morphology J:35802
abnormal lung morphology J:35802
abnormal motor neuron morphology J:35802
abnormal nasal pit morphology J:35802
abnormal neural tube morphology J:35802
abnormal optic cup morphology J:35802
abnormal optic stalk morphology J:35802
abnormal optic vesicle formation J:35802
abnormal spinal cord interneuron morphology J:73074
abnormal telencephalon morphology J:35802
absent cartilage J:35802
absent diencephalon J:35802
absent fibula J:35802
absent floor plate J:35802, J:73074
absent forelimb J:35802
absent hindlimb J:35802
absent tibia J:35802
absent vertebrae J:35802
adactyly J:35802
cyclopia J:35802, J:73074
decreased brain size J:35802
decreased midbrain size J:35802
decreased motor neuron number J:73074
decreased rib number J:35802
decreased spinal cord size J:35802
fetal growth retardation J:35802
increased apoptosis J:145182
notochord degeneration J:35802
perinatal lethality, incomplete penetrance J:35802
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal autopod morphology J:199480
abnormal forelimb zeugopod morphology J:199480
abnormal hindlimb zeugopod morphology J:199480
short limbs J:199480
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal otic vesicle development J:79100
abnormal posterior semicircular canal morphology J:79100
abnormal superior semicircular canal morphology J:79100
absent endolymphatic duct J:79100
absent lateral semicircular canal J:79100
absent scala media J:79100
absent utricle J:79100
absent vestibular saccule J:79100
absent vestibulocochlear ganglion J:79100
Shhtm1Chg/Shhtm1Chg
involves: C57BL/6
abnormal dorsal-ventral axis patterning J:89364
abnormal limb morphology J:89364
abnormal motor neuron morphology J:89364
abnormal neural tube morphology J:89364
abnormal somite shape J:89364
absent notochord J:89364
cyclopia J:89364
decreased somite size J:89364
embryonic growth retardation J:89364
holoprosencephaly J:89364
Shhtm1Chg/Shhtm2Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
abnormal artery morphology J:135134
abnormal cardiac outflow tract development J:135134
abnormal neural crest cell apoptosis J:135134
abnormal neural crest cell migration J:135134
persistent truncus arteriosus J:135134
Shhtm1Chg/Shhtm2Chg
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal carpal bone morphology J:109101
abnormal digit morphology J:109101
abnormal tarsal bone morphology J:109101
perinatal lethality J:125109
Shhtm1Chg/Shhtm2Chg
Tg(Mef2c-cre)2Blk/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
abnormal artery morphology J:135134
normal cardiovascular system phenotype J:135134
persistent truncus arteriosus J:135134
Shhtm1Ptch/Shhtm1Ptch
involves: 129P2/OlaHsd * FVB/N * various
abnormal ventral interneuron 2 morphology J:89228
abnormal ventral interneuron 3 morphology J:89228
decreased embryo size J:89228
decreased motor neuron number J:89228
holoprosencephaly J:89228
neonatal lethality, complete penetrance J:89228
oligodactyly J:89228
Shhtm2Amc/Shhtm2.1Amc
Tg(Nr5a1-cre)2Klp/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
abnormal adrenal gland morphology J:168522
abnormal adrenal gland physiology J:168522
abnormal adrenocortical cell morphology J:168522
decreased circulating corticosterone level J:168522
enlarged adrenocortical cells J:168522
increased circulating adrenocorticotropin level J:168522
small adrenal glands J:168522
thin adrenal cortex J:168522
Shhtm2Amc/Shhtm2Amc
Tg(Atp4b-cre/ERT2)1Jrgo/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal gastric surface mucous cell morphology J:191241
abnormal physiological neovascularization J:191241
abnormal stomach pH J:191241
delayed wound healing J:191241
normal digestive/alimentary phenotype J:191241
Shhtm2Amc/Shhtm2Amc
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
abnormal brain interneuron morphology J:102950
abnormal medial ganglionic eminence morphology J:102950
decreased body size J:147427
decreased brain size J:102950, J:147427
disorganized thalamus J:147427
microcephaly J:102950
postnatal growth retardation J:102950
postnatal lethality, complete penetrance J:102950
seizures J:102950
Shhtm2Amc/Shhtm2Amc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: FVB/N
abnormal branching involved in lung morphogenesis J:91723
abnormal bronchus morphology J:91723
abnormal lung morphology J:91723
abnormal trachea morphology J:91723
abnormal tracheal cartilage morphology J:91723
decreased tracheal cartilage ring number J:91723
lung cyst J:91723
neonatal lethality, complete penetrance J:91723
pulmonary hypoplasia J:91723
Shhtm2Amc/Shhtm3Amc
Tg(Pax2-cre)1Amc/0
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
abnormal astrocyte morphology J:92189
abnormal cerebellar granule cell morphology J:92189
abnormal cerebellar granule layer morphology J:92189
abnormal cerebellar molecular layer J:92189
abnormal cerebellar Purkinje cell layer J:92189
abnormal cerebellum development J:92189
abnormal cerebellum external granule cell layer morphology J:92189
abnormal cerebellum morphology J:92189
abnormal motor capabilities/coordination/movement J:92189
absent cerebellar lobules J:92189
ataxia J:92189
decreased Purkinje cell number J:92189
premature death J:92189
small cerebellum J:92189
Shhtm2Amc/Shhtm3Amc
Tg(Pcp2-cre)1Amc/0
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
abnormal cerebellar lobule formation J:92189
abnormal cerebellar Purkinje cell layer J:92189
abnormal cerebellum development J:92189
abnormal cerebellum morphology J:92189
abnormal motor capabilities/coordination/movement J:92189
ataxia J:92189
decreased Purkinje cell number J:92189
small cerebellum J:92189
thin external granule cell layer J:92189
Shhtm2Chg/Shh+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal choroid plexus morphology J:125109
abnormal corpus callosum morphology J:125109
abnormal embryonic/fetal subventricular zone morphology J:125109
abnormal hippocampus development J:125109
abnormal lateral ganglionic eminence morphology J:125109
abnormal maxillary shelf morphology J:125109
abnormal medial ganglionic eminence morphology J:125109
abnormal neurocranium morphology J:125109
abnormal telencephalon development J:125109
abnormal telencephalon morphology J:125109
absent olfactory bulb J:125109
cleft secondary palate J:125109
enlarged brain ventricles J:125109
holoprosencephaly J:125109
increased forebrain size J:125109
increased midbrain size J:125109
palatal shelves fail to meet at midline J:125109
perinatal lethality, complete penetrance J:125109
polydactyly J:109101
Shhtm2Chg/Shhtm2Chg
involves: 129S1/Sv * 129X1/SvJ
neonatal lethality, complete penetrance J:109101
Shhtm3(cre)Chg/Shhtm3(cre)Chg
Not Specified
abnormal cardiovascular system morphology J:160335
abnormal cell physiology J:160335
abnormal craniofacial morphology J:160335
abnormal digestive system morphology J:160335
abnormal embryo development J:160335
abnormal eye morphology J:160335
abnormal nervous system morphology J:160335
abnormal prenatal growth/weight/body size J:160335
abnormal respiratory system morphology J:160335
abnormal skeleton morphology J:160335
perinatal lethality J:160335
Shhtm6Amc/Shhtm6Amc
Not Specified
lethality throughout fetal growth and development, incomplete penetrance J:132152
Tg(KRT14-Shh)#Cobm/0
involves: C57BL/6 * CBA
abnormal basioccipital bone morphology J:150375
abnormal craniofacial morphology J:150375
abnormal dental arch morphology J:150375
abnormal epidermal layer morphology J:150375
abnormal exoccipital bone morphology J:150375
abnormal frontal bone morphology J:150375
abnormal malleus manubrium morphology J:150375
abnormal maxilla morphology J:150375
abnormal middle ear ossicle morphology J:150375
abnormal neurocranium morphology J:150375
abnormal otic capsule morphology J:150375
abnormal palatal rugae morphology J:150375
abnormal palatal shelf fusion at midline J:150375
abnormal parietal bone morphology J:150375
abnormal premaxilla morphology J:150375
abnormal styloid process morphology J:150375
abnormal tooth development J:150375
abnormal upper lip morphology J:150375
abnormal vertebral arch morphology J:150375
abnormal viscerocranium morphology J:150375
absent palatine bone horizontal plate J:150375
absent supraoccipital bone J:150375
arrest of tooth development J:150375
cleft palate J:150375
cleft secondary palate J:150375
decreased maxillary shelf size J:150375
decreased palatal rugae number J:150375
ectopic cranial bone J:150375
epidermal hyperplasia J:150375
gonial bone hypoplasia J:150375
increased basal cell carcinoma incidence J:150375
kinked tail J:150375
malocclusion J:150375
ocular hypertelorism J:150375
persistence of medial edge epithelium during palatal shelf fusion J:150375
polysyndactyly J:150375
shiny skin J:150375
short limbs J:150375
small mandibular coronoid process J:150375
spina bifida J:150375
split sternum J:150375
syndactyly J:150375
temporal bone squamous part hypoplasia J:150375
tight skin J:150375
translucent skin J:150375
tympanic ring hypoplasia J:150375
Tg(Shh)#Dje/0
involves: CD-1
abnormal cochlear sensory epithelium morphology J:79100
abnormal inner ear vestibule morphology J:79100
abnormal scala media morphology J:79100
abnormal vestibulocochlear ganglion morphology J:79100
absent semicircular canals J:79100
absent utricle J:79100
absent vestibular saccule J:79100
circling J:79100
head bobbing J:79100
hyperactivity J:79100
Tg(Shh)#Dje/0
involves: Swiss Webster
abnormal cell proliferation J:94461
abnormal cerebellar cortex morphology J:94461
abnormal cerebellar granule layer morphology J:94461, J:108507
abnormal cerebellum external granule cell layer morphology J:94461
abnormal cerebellum morphology J:94461, J:108507

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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory