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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rac1
Rac family small GTPase 1
MGI:97845
122 phenotypes from 10 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cd19tm1(cre)Cgn/\Cd19+
\Rac1tm1Tyb/\Rac1tm1Tyb
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		normal immune system phenotype J:86765
\Emx1tm1(cre)Ito/\Emx1+
\Rac1tm1Atai/\Rac1tm1Jms
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR 		abnormal barrel cortex morphology J:140575
abnormal brain commissure morphology J:140575
abnormal corpus callosum morphology J:140575
abnormal dentate gyrus morphology J:140575
abnormal hippocampus pyramidal cell layer J:140575
abnormal telencephalon morphology J:140575
decreased anterior commissure size J:140575
decreased hippocampal commissure size J:140575
decreased survivor rate J:140575
postnatal lethality, incomplete penetrance J:140575
small hippocampus J:140575
\Gt(ROSA)26Sortm9(Rac1*,-EGFP)Rsky/\Gt(ROSA)26Sor+
\Ptf1atm1(cre)Hnak/\Ptf1a+
involves: C57BL/6 		normal endocrine/exocrine gland phenotype J:197054
normal neoplasm J:197054
\Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
involves: 129S4/SvJae * C57BL/6 		normal renal/urinary system phenotype J:206088
\Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
\Tg(Nphs1-rtTA*3G)8Jhm/0
involves: 129S4/SvJae * C57BL/6 		increased urine protein level J:206088
normal renal/urinary system phenotype J:206088
\Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
\Tg(NPHS2-rtTA2*M2)1Jbk/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		increased urine protein level J:206088
podocyte foot process effacement J:206088
\Rac1em1(IMPC)Mbp/\Rac1+
C57BL/6N-Rac1em1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
abnormal lymph node morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
anophthalmia J:211773
decreased mean corpuscular hemoglobin J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
hyperactivity J:211773
increased circulating alkaline phosphatase level J:211773
increased erythrocyte cell number J:211773
microphthalmia J:211773
small kidney J:211773
small testis J:211773
\Rac1em1(IMPC)Mbp/\Rac1em1(IMPC)Mbp
C57BL/6N-Rac1em1(IMPC)Mbp/MbpMmucd 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
\Rac1tm1.1Djk/\Rac1tm1.1Djk
involves: 129S4/SvJae * C57BL/6 		embryonic lethality between somite formation and embryo turning, complete penetrance J:83457
\Rac1tm1Brak/\Rac1tm1Brak
\Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J 		abnormal coat/ hair morphology J:112307
abnormal hair follicle morphology J:112307
abnormal hair shaft morphology J:112307
abnormal keratinocyte physiology J:112307
abnormal skin condition J:112307
abnormal skin physiology J:112307
abnormal skin pigmentation J:112307
alopecia J:112307
enlarged sebaceous gland J:112307
normal reproductive system phenotype J:112307
\Rac1tm1Djk/\Rac1tm1.1Djk
\Lyz2tm1(cre)Ifo/\Lyz2+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		decreased acute inflammation J:83457
decreased leukocyte cell number J:83457
decreased neutrophil cell number J:83457
impaired neutrophil chemotaxis J:83457
impaired neutrophil recruitment J:83457
\Rac1tm1Djk/\Rac1tm1.1Djk
\Tg(Msx2-cre)5Rem/0
involves: 129S4/SvJae 		absent hindlimb J:145305
short forelimb J:145305
\Rac1tm1Djk/\Rac1tm1.1Djk
\Tg(Myh6-cre/Esr1*)1Liao/0
involves: 129S4/SvJae * C57BL/6 		abnormal enzyme/coenzyme activity J:109582
abnormal myocardial fiber morphology J:109582
abnormal myocardium layer morphology J:109582
cardiac hypertrophy J:109582
increased heart left ventricle weight J:109582
increased NAD(P)H oxidase activity J:109582
oxidative stress J:109582
\Rac1tm1Djk/\Rac1tm1Djk
\Tg(KRT14-cre/ERT)20Efu/0
involves: 129S4/SvJae * C57BL/6 * CD-1 		abnormal epidermal layer morphology J:99995
abnormal epidermis stratum basale morphology J:99995
abnormal hair cycle J:99995
abnormal hair follicle bulge morphology J:99995
abnormal hair follicle infundibulum morphology J:99995
abnormal hair follicle morphology J:99995
abnormal keratinocyte physiology J:99995
abnormal sebocyte number J:99995
abnormal skin cell number J:99995
absent hair follicle bulb J:99995
enlarged sebaceous gland J:99995
\Rac1tm1Djk/\Rac1tm1Djk
\Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJae * BALB/c * C57BL/6 		abnormal cell adhesion J:315097
abnormal fetal cardiomyocyte morphology J:315097
abnormal heart apex morphology J:315097
abnormal heart right ventricle morphology J:315097
abnormal interventricular groove morphology J:315097
abnormal interventricular septum morphology J:315097
abnormal ventricle myocardium morphology J:315097
atrial septal defect J:315097
increased apoptosis J:315097
perinatal lethality, incomplete penetrance J:315097
thin right ventricle myocardium compact layer J:315097
trabecula carnea hypoplasia J:315097
ventricular septal defect J:315097
\Rac1tm1Djk/\Rac1tm1Djk
\Tg(Nkx2-5-cre)9Eno/0
involves: 129S4/SvJae * BALB/c * C57BL/6 		abnormal cardiac outflow tract development J:321017
abnormal fetal cardiomyocyte morphology J:321017
abnormal heart apex morphology J:321017
abnormal heart development J:321017
abnormal heart morphology J:321017
abnormal myocardium compact layer morphology J:321017
abnormal trabecula carnea morphology J:321017
abnormal ventricle myocardium morphology J:321017
decreased fetal cardiomyocyte proliferation J:321017
double outlet right ventricle J:321017
overriding aortic valve J:321017
perinatal lethality, complete penetrance J:321017
thin myocardium compact layer J:321017
thin ventricle myocardium compact layer J:321017
ventricular septal defect J:321017
\Rac1tm1Djk/\Rac1tm1Djk
\Tg(Pf4-icre)Q3Rsko/0
involves: 129S4/SvJae * C57BL/6 		abnormal platelet activation J:214607
decreased platelet aggregation J:214607
\Rac1tm1Jms/\Rac1tm1Jms
involves: 129S/SvEv * C57BL/6J 		abnormal embryonic epiblast morphology J:52224
abnormal embryonic-extraembryonic boundary morphology J:52224
abnormal gastrulation J:52224
abnormal germ layer development J:52224
abnormal rostral-caudal body axis extension J:52224
absent mesoderm J:52224
absent somites J:52224
decreased embryo size J:52224
embryonic lethality during organogenesis, complete penetrance J:52224
increased apoptosis J:52224
thick embryonic epiblast J:52224
\Rac1tm1Tyb/\Rac1tm2Tyb
\Edil3Tg(Sox2-cre)1Amc/\Edil3+
involves: 129S4/SvJae * C3H * C57BL/6 * CBA 		abnormal cell adhesion J:173526
abnormal developmental patterning J:173526
abnormal mesoderm development J:173526
abnormal neural tube closure J:173526
abnormal notochordal plate morphology J:173526
abnormal primitive node morphology J:173526
abnormal primitive streak morphology J:173526
cardia bifida J:173526
decreased cell proliferation J:173526
decreased embryo size J:173526
impaired somite development J:173526
increased embryonic tissue cell apoptosis J:173526
prenatal lethality, complete penetrance J:166095
\Rac1tm1Tyb/\Rac1tm2Tyb
\Tg(Ttr-cre)1Hadj/0
involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J 		abnormal anterior visceral endoderm cell migration J:166095
abnormal craniofacial development J:166095
abnormal extraembryonic endoderm formation J:173526
abnormal rostral-caudal axis patterning J:166095
embryonic lethality, complete penetrance J:166095
embryonic-extraembryonic boundary constriction J:166095
\Rac1tm2Tyb/\Rac1tm2Tyb
involves: 129S4/SvJae * C3H * C57BL/6 * CD-1 		abnormal anterior visceral endoderm cell migration J:166095
abnormal primitive streak formation J:166095
embryonic growth arrest J:166095
embryonic lethality between implantation and somite formation, complete penetrance J:166095
embryonic-extraembryonic boundary constriction J:166095
\Rac1tm2Tyb/\Rac1tm2Tyb
involves: 129S4/SvJae * C57BL/6 		embryonic lethality, complete penetrance J:86765
\Rac1tm2Tyb/\Rac1tm2Tyb
\Tg(Hhex-EGFP)#Rbe/0
mixed 		abnormal anterior visceral endoderm cell migration J:166095
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory