About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rac1
Rac family small GTPase 1
MGI:97845
123 phenotypes from 10 alleles in 15 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Rac1tm1Tyb/Rac1tm1Tyb
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		normal immune system phenotype J:86765
Emx1tm1(cre)Ito/Emx1+
Rac1tm1Atai/Rac1tm1Jms
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR 		abnormal barrel cortex morphology J:140575
abnormal brain commissure morphology J:140575
abnormal corpus callosum morphology J:140575
abnormal dentate gyrus morphology J:140575
abnormal hippocampus pyramidal cell layer J:140575
abnormal telencephalon morphology J:140575
decreased anterior commissure size J:140575
decreased hippocampal commissure size J:140575
decreased survivor rate J:140575
postnatal lethality, incomplete penetrance J:140575
small hippocampus J:140575
Gt(ROSA)26Sortm9(Rac1*,-EGFP)Rsky/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: C57BL/6 		normal endocrine/exocrine gland phenotype J:197054
normal neoplasm J:197054
Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
involves: 129S4/SvJae * C57BL/6 		normal renal/urinary system phenotype J:206088
Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Tg(Nphs1-rtTA*3G)8Jhm/0
involves: 129S4/SvJae * C57BL/6 		increased urine protein level J:206088
normal renal/urinary system phenotype J:206088
Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Tg(NPHS2-rtTA2*M2)1Jbk/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		increased urine protein level J:206088
podocyte foot process effacement J:206088
Rac1em1(IMPC)Mbp/Rac1+
C57BL/6N-Rac1em1(IMPC)Mbp/MbpMmucd 		abnormal eye morphology J:211773
abnormal lymph node morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
anophthalmia J:211773
decreased mean corpuscular hemoglobin J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
hyperactivity J:211773
increased circulating alkaline phosphatase level J:211773
increased erythrocyte cell number J:211773
microphthalmia J:211773
small kidney J:211773
small testis J:211773
Rac1em1(IMPC)Mbp/Rac1em1(IMPC)Mbp
C57BL/6N-Rac1em1(IMPC)Mbp/MbpMmucd 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Rac1tm1.1Djk/Rac1tm1.1Djk
involves: 129S4/SvJae * C57BL/6 		embryonic lethality between somite formation and embryo turning, complete penetrance J:83457
Rac1tm1Brak/Rac1tm1Brak
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J 		abnormal coat/ hair morphology J:112307
abnormal hair follicle morphology J:112307
abnormal hair shaft morphology J:112307
abnormal keratinocyte physiology J:112307
abnormal skin condition J:112307
abnormal skin physiology J:112307
abnormal skin pigmentation J:112307
alopecia J:112307
enlarged sebaceous gland J:112307
normal reproductive system phenotype J:112307
Rac1tm1Djk/Rac1tm1.1Djk
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		decreased acute inflammation J:83457
decreased leukocyte cell number J:83457
decreased neutrophil cell number J:83457
impaired neutrophil chemotaxis J:83457
impaired neutrophil recruitment J:83457
Rac1tm1Djk/Rac1tm1.1Djk
Tg(Msx2-cre)5Rem/0
involves: 129S4/SvJae 		absent hindlimb J:145305
short forelimb J:145305
Rac1tm1Djk/Rac1tm1.1Djk
Tg(Myh6-cre/Esr1*)1Liao/0
involves: 129S4/SvJae * C57BL/6 		abnormal enzyme/coenzyme activity J:109582
abnormal myocardial fiber morphology J:109582
abnormal myocardium layer morphology J:109582
cardiac hypertrophy J:109582
increased heart left ventricle weight J:109582
increased NAD(P)H oxidase activity J:109582
oxidative stress J:109582
Rac1tm1Djk/Rac1tm1Djk
Tg(KRT14-cre/ERT)20Efu/0
involves: 129S4/SvJae * C57BL/6 * CD-1 		abnormal epidermal layer morphology J:99995
abnormal epidermis stratum basale morphology J:99995
abnormal hair cycle J:99995
abnormal hair follicle bulge morphology J:99995
abnormal hair follicle infundibulum morphology J:99995
abnormal hair follicle morphology J:99995
abnormal keratinocyte physiology J:99995
abnormal sebocyte number J:99995
abnormal skin cell number J:99995
absent hair follicle bulb J:99995
enlarged sebaceous gland J:99995
Rac1tm1Djk/Rac1tm1Djk
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJae * BALB/c * C57BL/6 		abnormal cell adhesion J:315097
abnormal fetal cardiomyocyte morphology J:315097
abnormal heart apex morphology J:315097
abnormal heart right ventricle morphology J:315097
abnormal interventricular groove morphology J:315097
abnormal interventricular septum morphology J:315097
abnormal ventricle myocardium morphology J:315097
atrial septal defect J:315097
increased apoptosis J:315097
perinatal lethality, incomplete penetrance J:315097
thin right ventricle myocardium compact layer J:315097
trabecula carnea hypoplasia J:315097
ventricular septal defect J:315097
Rac1tm1Djk/Rac1tm1Djk
Tg(Nkx2-5-cre)9Eno/0
involves: 129S4/SvJae * BALB/c * C57BL/6 		abnormal cardiac outflow tract development J:321017
abnormal fetal cardiomyocyte morphology J:321017
abnormal heart apex morphology J:321017
abnormal heart development J:321017
abnormal heart morphology J:321017
abnormal myocardium compact layer morphology J:321017
abnormal trabecula carnea morphology J:321017
abnormal ventricle myocardium morphology J:321017
decreased fetal cardiomyocyte proliferation J:321017
double outlet right ventricle J:321017
overriding aortic valve J:321017
perinatal lethality, complete penetrance J:321017
thin myocardium compact layer J:321017
thin ventricle myocardium compact layer J:321017
ventricular septal defect J:321017
Rac1tm1Djk/Rac1tm1Djk
Tg(Pf4-icre)Q3Rsko/0
involves: 129S4/SvJae * C57BL/6 		abnormal platelet activation J:214607
decreased platelet aggregation J:214607
Rac1tm1Jms/Rac1tm1Jms
involves: 129S/SvEv * C57BL/6J 		abnormal embryonic epiblast morphology J:52224
abnormal embryonic-extraembryonic boundary morphology J:52224
abnormal gastrulation J:52224
abnormal germ layer development J:52224
abnormal rostral-caudal body axis extension J:52224
absent mesoderm J:52224
absent somites J:52224
decreased embryo size J:52224
embryonic lethality during organogenesis, complete penetrance J:52224
increased apoptosis J:52224
thick embryonic epiblast J:52224
Rac1tm1Tyb/Rac1tm2Tyb
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C3H * C57BL/6 * CBA 		abnormal developmental patterning J:173526
abnormal mesoderm development J:173526
abnormal neural tube closure J:173526
abnormal notochordal plate morphology J:173526
abnormal primitive node morphology J:173526
abnormal primitive streak morphology J:173526
cardia bifida J:173526
decreased cell adhesion J:173526
decreased cell proliferation J:173526
decreased embryo size J:173526
impaired somite development J:173526
increased embryonic tissue cell apoptosis J:173526
prenatal lethality, complete penetrance J:166095
Rac1tm1Tyb/Rac1tm2Tyb
Tg(Ttr-cre)1Hadj/0
involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J 		abnormal anterior visceral endoderm cell migration J:166095
abnormal craniofacial development J:166095
abnormal extraembryonic endoderm formation J:173526
abnormal rostral-caudal axis patterning J:166095
embryonic lethality, complete penetrance J:166095
embryonic-extraembryonic boundary constriction J:166095
Rac1tm2Tyb/Rac1tm2Tyb
involves: 129S4/SvJae * C3H * C57BL/6 * CD-1 		abnormal anterior visceral endoderm cell migration J:166095
abnormal primitive streak formation J:166095
embryonic growth arrest J:166095
embryonic lethality between implantation and somite formation, complete penetrance J:166095
embryonic-extraembryonic boundary constriction J:166095
Rac1tm2Tyb/Rac1tm2Tyb
involves: 129S4/SvJae * C57BL/6 		embryonic lethality, complete penetrance J:86765
Rac1tm2Tyb/Rac1tm2Tyb
Tg(Hhex-EGFP)#Rbe/0
mixed 		abnormal anterior visceral endoderm cell migration J:166095
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
07/22/2025
MGI 6.24 		The Jackson Laboratory