77 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Alpltm1(cre)Nagy/Alpl+ Dmrt1tm1Zark/Dmrt1tm1.1Zark involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal spermatogonia morphology	J:122954
	abnormal testis development	J:122954
	decreased male germ cell number	J:122954
Alpltm1(cre)Nagy/Alpl+ Dnmt3atm3.1Enl/Dnmt3atm3.2Enl involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	azoospermia	J:91108
	decreased testis weight	J:91108
	female infertility	J:91108
	male infertility	J:91108
Alpltm1(cre)Nagy/Alpl+ Dnmt3btm5.1Enl/Dnmt3btm5.2Enl involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N	normal reproductive system phenotype	J:91108
Alpltm1(cre)Nagy/Alpl+ Pou5f1tm1Scho/Pou5f1tm1.1Scho involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal gonadal ridge morphology	J:95317
	absent ovarian follicles	J:95317
	decreased primordial germ cell number	J:95317
	decreased primordial ovarian follicle number	J:95317
	female infertility	J:95317
	increased Leydig cell number	J:95317
	oligozoospermia	J:95317
	reduced male fertility	J:95317
	small seminiferous tubules	J:95317
Alpltm1(cre)Nagy/Alpl+ Atg7tm1Tchi/Atg7tm1Tchi involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	abnormal acrosome assembly	J:258511
	abnormal acrosome morphology	J:258511
	abnormal cauda epididymis morphology	J:258511
	abnormal proacrosomal vesicle fusion	J:258511
	abnormal seminiferous tubule morphology	J:258511
	abnormal sperm nucleus morphology	J:258511
	abnormal spermiogenesis	J:258511
	decreased testis weight	J:258511
	globozoospermia	J:258511
	impaired acrosome reaction	J:258511
	impaired autophagy	J:258511
	impaired fertilization	J:258511
	increased male germ cell apoptosis	J:258511
	oligozoospermia	J:258511
	reduced male fertility	J:258511
	small testis	J:258511
Alpltm1(cre)Nagy/Alpl+ Ehmt2tm2Yshk/Ehmt2tm2.1Yshk involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal female meiosis	J:123269
	abnormal fertility/fecundity	J:123269
	abnormal gametogenesis	J:123269
	arrest of male meiosis	J:123269
	azoospermia	J:123269
	decreased litter size	J:123269
	decreased male germ cell number	J:123269
	decreased oocyte number	J:123269
	female infertility	J:123269
	male infertility	J:123269
	small testis	J:123269
Alpltm1(cre)Nagy/Alpl+ Xrcc1tm1Pmc/Xrcc1tm1Pmc involves: 129S1/Sv * 129X1/SvJ	abnormal mitochondrial ATP synthesis coupled electron transport	J:292217
	abnormal mitochondrial morphology	J:292217
	abnormal mitochondrial physiology	J:292217
	abnormal seminiferous tubule epithelium morphology	J:292217
	abnormal seminiferous tubule morphology	J:292217
	abnormal spermatocyte morphology	J:292217
	abnormal spermatogenesis	J:292217
	abnormal spermatogonia morphology	J:292217
	asthenozoospermia	J:292217
	decreased catalase activity	J:292217
	decreased testis weight	J:292217
	increased testis apoptosis	J:292217
	male infertility	J:292217
	oligozoospermia	J:292217
	oxidative stress	J:292217
	small testis	J:292217
Alpltm1(cre)Nagy/Alpl+ Dicer1tm1.1Mnn/Dicer1tm1.2Mnn involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J	abnormal meiotic spindle morphology	J:150221
	abnormal oocyte morphology	J:150221
Alpltm1(cre)Nagy/Alpl+ Tet3tm1.1Gxu/Tet3tm1.2Gxu involves: 129 * C57BL/6J * SJL	abnormal DNA methylation	J:176196
	maternal effect	J:176196
	reduced female fertility	J:176196
Alpltm1(cre)Nagy/Alpl+ Pknox1tm1.1Rygo/Pknox1tm1.1Rygo involves: 129 * C57BL/6 * C57BL/6JJcl	abnormal spermatogonia morphology	J:258387
	abnormal spermatogonia proliferation	J:258387
	arrest of spermatogenesis	J:258387
	azoospermia	J:258387
	decreased male germ cell number	J:258387
	decreased testis weight	J:258387
	increased male germ cell apoptosis	J:258387
	seminiferous tubule degeneration	J:258387
	small testis	J:258387
Alpltm1(cre)Nagy/Alpl+ Phldb2tm1Msat/Phldb2tm1Msat involves: 129S1/Sv * 129X1/SvJ * C57BL/6JSlc * C57BL/6NCrlj * CBA/JNCrlj	abnormal dendritic spine morphology	J:275597
	abnormal spatial reference memory	J:275597
	normal behavior/neurological phenotype	J:275597
	reduced long-term potentiation	J:275597
Alpltm1Jlm/Alpl+ Phospho1m1Jlm/Phospho1m1Jlm involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6	bowed tibia	J:173678
	decreased bone mineralization	J:173678
	decreased bone ossification	J:173678
	fragile skeleton	J:173678
	prenatal lethality, incomplete penetrance	J:173678
	scoliosis	J:173678
Alpltm1Jlm/Alpltm1Jlm Phospho1m1Jlm/Phospho1m1Jlm involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6	abnormal bone mineralization	J:173678
	lethality throughout fetal growth and development, complete penetrance	J:173678
Alpltm1Jlm/Alpltm1Jlm Spp1tm1Rit/Spp1tm1Rit involves: 129S1/SvImJ * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	abnormal dentin morphology	J:233260
	abnormal tooth root development	J:233260
Alpltm1Jlm/Alpltm1Jlm Spp1tm1Rit/Spp1tm1Rit involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	abnormal osteoblast physiology	J:128077
	decreased body weight	J:128077
	decreased bone mineralization	J:128077
	increased bone mineral density of lumbar vertebrae	J:128077
	increased bone mineral density of presacral vertebrae	J:128077
	increased bone trabecula number	J:128077
	postnatal lethality, complete penetrance	J:128077
Chtf18tm1.1KhK/Chtf18tm1.2Khk Alpltm1(cre)Nagy/Alpl+ involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal male germ cell morphology	J:194119
Guf1tm1Nju/Guf1tm1Nju Alpltm1(cre)Nagy/Alpl+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased testis weight	J:333298
	male infertility	J:333298
	oligozoospermia	J:333298
	small seminiferous tubules	J:333298
Resttm1.1Yasu/Resttm1.2Yasu Alpltm1(cre)Nagy/Alpl+ involves: 129 * C57BL/6 * C57BL/6J	decreased primordial germ cell number	J:190948
	increased primordial germ cell apoptosis	J:190948
	normal reproductive system phenotype	J:190948
Snrpntm2.1Kaj/Snrpn+ Alpltm1(cre)Nagy/Alpl+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal DNA methylation	J:174457
	absent gastric milk in neonates	J:174457
	decreased birth weight	J:174457
	postnatal lethality, complete penetrance	J:174457