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Phospho1m1Jlm
Chemically induced Allele Detail
Summary
Symbol: Phospho1m1Jlm
Name: phosphatase, orphan 1; mutation 1, Jose Luis Millan
MGI ID: MGI:5049904
Synonyms: Phospho1-R74X
Gene: Phospho1  Location: Chr11:95715326-95722966 bp, + strand  Genetic Position: Chr11, 59.01 cM
Alliance: Phospho1m1Jlm page
Mutation
origin
Strain of Origin:  C3HeB/FeJ
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Nucleotide substitutions
 
Mutation detailsENU mutagenesis induced a nucleotide substitution(s) that results in the amino acid substitution of a stop codon for arginine at position 74 (R74X). The absence of protein expression was confirmed by western blot analysis on long bone extracts. (J:173678)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 16 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phospho1 Mutation:  10 strains or lines available
References
Original:  J:173678 Yadav MC, et al., Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification. J Bone Miner Res. 2011 Feb;26(2):286-97
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory