Alpl^tm1Jlm
Targeted Allele Detail

Summary

• Symbol: Alpl^tm1Jlm
• Name: alkaline phosphatase, liver/bone/kidney; targeted mutation 1, Jose Luis Millan
• MGI ID: MGI:2183411
• Synonyms: Akp2^-, Akp2 KO, TNAP-
• Gene: Alpl Location: Chr4:137469044-137523695 bp, - strand Genetic Position: Chr4, 70.02 cM
• Alliance: Alpl^tm1Jlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39015
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 6 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot and RT-PCR analysis. (J:39015)

Disease models

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alpl Mutation: 351 strains or lines available

References

• Original: J:39015 Narisawa S, et al., Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn. 1997 Mar;208(3):432-46
• All: 31 reference(s)