Dnmt3a^tm3.1Enl
Targeted Allele Detail

Summary

• Symbol: Dnmt3a^tm3.1Enl
• Name: DNA methyltransferase 3A; targeted mutation 3.1, En Li
• MGI ID: MGI:3047552
• Synonyms: Dnmt3a^2lox, Dnmt3a^2loxP, Dnmt3a^fl, Dnmt3a^flox
• Gene: Dnmt3a Location: Chr12:3856007-3964443 bp, + strand Genetic Position: Chr12, 1.99 cM, cytoband A2-A3
• Alliance: Dnmt3a^tm3.1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91108
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele was created by crossing Dnmt3a^tm3Enl with Ella-cre mice, thereby excising the floxed neo and leaving exon 19 floxed. Exon 19 encodes the conserved PC motif of the catalytic domain. (J:91108)

Expression

In Mice Carrying this Mutation:	4 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dnmt3a Mutation: 138 strains or lines available

References

• Original: J:91108 Kaneda M, et al., Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature. 2004 Jun 24;429(6994):900-3
• All: 87 reference(s)