About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nlrp3
NLR family, pyrin domain containing 3
MGI:2653833
104 phenotypes from 21 alleles in 27 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Nlrp3m1Btlr/Nlrp3m1Btlr
C57BL/6J-Nlrp3m1Btlr 		decreased interleukin-1 beta secretion J:159357
Nlrp3m2Btlr/?
C57BL/6J-Nlrp3m2Btlr 		abnormal interleukin-1 beta secretion J:164865
Nlrp3m3Btlr/?
C57BL/6J-Nlrp3m3Btlr 		abnormal interleukin-1 beta secretion J:164866
Nlrp3m4Btlr/Nlrp3m4Btlr
involves: C57BL/6J 		decreased interleukin-1 beta secretion J:171739
Nlrp3m5Btlr/Nlrp3+
C57BL/6J-Nlrp3m5Btlr 		decreased interleukin-1 beta secretion J:192651
Nlrp3m5Btlr/Nlrp3m5Btlr
C57BL/6J-Nlrp3m5Btlr 		decreased interleukin-1 beta secretion J:192651
Nlrp3M6Btlr/Nlrp3+
C57BL/6J-Nlrp3M6Btlr 		decreased interleukin-1 beta secretion J:216047
Nlrp3M6Btlr/Nlrp3M6Btlr
C57BL/6J-Nlrp3M6Btlr 		decreased susceptibility to experimental autoimmune encephalomyelitis J:226677
Nlrp3M7Btlr/Nlrp3+
C57BL/6J-Nlrp3M7Btlr 		abnormal macrophage cytokine production J:216048
decreased interleukin-1 beta secretion J:216048
Nlrp3M7Btlr/Nlrp3M7Btlr
C57BL/6J-Nlrp3M7Btlr 		abnormal macrophage cytokine production J:216048
decreased interleukin-1 beta secretion J:216048
Nlrp3M8Btlr/Nlrp3+
C57BL/6J-Nlrp3M8Btlr 		decreased interleukin-1 beta secretion J:217294
Nlrp3M8Btlr/Nlrp3M8Btlr
C57BL/6J-Nlrp3M8Btlr 		decreased interleukin-1 beta secretion J:217294
Nlrp3M9Btlr/Nlrp3+
C57BL/6J-Nlrp3M9Btlr 		decreased interleukin-1 beta secretion J:220071
Nlrp3M9Btlr/Nlrp3M9Btlr
C57BL/6J-Nlrp3M9Btlr 		decreased interleukin-1 beta secretion J:220071
Nlrp3M10Btlr/Nlrp3+
C57BL/6J-Nlrp3M10Btlr 		decreased interleukin-1 beta secretion J:234254
Nlrp3M10Btlr/Nlrp3M10Btlr
C57BL/6J-Nlrp3M10Btlr 		decreased interleukin-1 beta secretion J:234254
Nlrp3M11Btlr/Nlrp3M11Btlr
C57BL/6J-Nlrp3M11Btlr 		decreased interleukin-1 beta secretion J:255211
Nlrp3m12Btlr/Nlrp3m12Btlr
C57BL/6J-Nlrp3m12Btlr 		decreased interleukin-1 beta secretion J:272150
Nlrp3tm1Bhk/Nlrp3tm1Bhk
B6.129S6-Nlrp3tm1Bhk/J 		abnormal digestive system physiology J:256504
abnormal gut flora balance J:256504
abnormal lipid metabolism J:256504
abnormal liver morphology J:256504
decreased energy expenditure J:256504
decreased interleukin-1 beta secretion J:253629
hepatic steatosis J:256504
increased body fat mass J:256504
increased liver triglyceride level J:256504
increased liver weight J:256504
increased susceptibility to diet-induced obesity J:256504
oxidative stress J:256504
white adipose tissue inflammation J:256504
Nlrp3tm1Bhk/Nlrp3tm1Bhk
involves: 129S6/SvEvTac 		decreased interleukin-1 beta secretion J:189777
decreased lactate dehydrogenase level J:189777
normal immune system phenotype J:189777
Nlrp3tm1Flv/Nlrp3tm1Flv
B6.129S5-Nlrp3tm1Flv 		decreased interleukin-1 beta secretion J:164725
Nlrp3tm1Flv/Nlrp3tm1Flv
involves: 129S5/SvEvBrd 		decreased susceptibility to induced colitis J:173245
Nlrp3tm1Flv/Nlrp3tm1Flv
involves: 129S5/SvEvBrd * C57BL/6 		abnormal macrophage physiology J:113333
decreased circulating interleukin-1 beta level J:113333
decreased circulating interleukin-18 level J:113333
decreased susceptibility to endotoxin shock J:113333
decreased susceptibility to type IV hypersensitivity reaction J:113333
Nlrp3tm1Flv/Nlrp3tm1Hhf
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129 * C57BL/6 		increased inflammatory response J:150054
postnatal lethality, complete penetrance J:150054
Nlrp3tm1Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal circulating chemokine level J:150054
abnormal circulating cytokine level J:150054
abnormal intestine morphology J:150054
abnormal kidney morphology J:150054
hairless J:150054
increased circulating interleukin-1 beta level J:150054
increased circulating interleukin-6 level J:150054
increased circulating interleukin-18 level J:150054
increased circulating tumor necrosis factor level J:150054
increased inflammatory response J:150054
increased leukocyte cell number J:150054
increased neutrophil cell number J:150054
postnatal lethality, complete penetrance J:150054
reddish skin J:150054
scaly skin J:150054
slow postnatal weight gain J:150054
thrombocytosis J:150054
Nlrp3tm1Hhf/Nlrp3+
Tg(Zp3-cre)3Mrt/?
involves: 129/Sv * FVB/N 		abnormal intestine morphology J:150054
abnormal kidney morphology J:150054
hairless J:150054
increased inflammatory response J:150054
increased leukocyte cell number J:150054
increased neutrophil cell number J:150054
postnatal lethality, complete penetrance J:150054
reddish skin J:150054
scaly skin J:150054
slow postnatal weight gain J:150054
thrombocytosis J:150054
Nlrp3tm1Hhf/Nlrp3+
Tg(CAG-cre/Esr1*)5Amc/?
involves: 129/Sv * C57BL/6 * CBA 		abnormal dendritic cell antigen presentation J:150054
abnormal dendritic cell physiology J:150054
abnormal macrophage physiology J:150054
Nlrp3tm1Tsc/Nlrp3tm1Tsc
C57BL/6-Nlrp3tm1Tsc 		decreased interleukin-1 beta secretion J:124226
Nlrp3tm1Tsc/Nlrp3tm1Tsc
involves: C57BL/6 		decreased interleukin-1 beta secretion J:172117
Nlrp3tm1Vmd/Nlrp3tm1Vmd
B6.B6N-Nlrp3tm1Vmd 		decreased circulating interleukin-1 beta level J:193522
decreased circulating interleukin-18 level J:193522
decreased interleukin-1 beta secretion J:193522
decreased susceptibility to endotoxin shock J:193522
normal immune system phenotype J:294930
Nlrp3tm1Vmd/Nlrp3tm1Vmd
involves: C57BL/6N 		abnormal cytokine secretion J:106976
abnormal response to infection J:106976
decreased susceptibility to endotoxin shock J:106976
Nlrp3tm1Wstr/Nlrp3+
involves: C57BL/6 		abnormal bone marrow cell physiology J:150053
abnormal CD4-positive, alpha-beta T cell number J:150053
abnormal dendritic cell physiology J:150053
abnormal lymph node morphology J:150053
abnormal macrophage physiology J:150053
abnormal spleen red pulp morphology J:150053
chronic inflammation J:150053
decreased survivor rate J:150053
dermatitis J:150053
enlarged liver J:150053
enlarged lymph nodes J:150053
enlarged spleen J:150053
increased activated T cell number J:150053
increased anti-double stranded DNA antibody level J:150053
increased interleukin-1 beta secretion J:150053
increased interleukin-17 secretion J:150053
increased interleukin-18 secretion J:150053
increased leukocyte cell number J:150053
increased susceptibility to type IV hypersensitivity reaction J:150053
increased T-helper 1 cell number J:150053
postnatal growth retardation J:150053
reduced fertility J:150053
slow postnatal weight gain J:150053
Nlrp3tm2Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		perinatal lethality, complete penetrance J:150054
Nlrp3tm2Hhf/Nlrp3+
Tg(CAG-cre/Esr1*)5Amc/?
involves: 129/Sv * C57BL/6 * CBA 		abnormal dendritic cell physiology J:150054
abnormal macrophage physiology J:150054
Nlrp3tm3.1Hhf/Nlrp3+
involves: 129 		abnormal bone marrow cavity morphology J:202147
abnormal bone marrow cell physiology J:202147
abnormal chondrocyte physiology J:202147
abnormal circulating chemokine level J:202147
abnormal long bone epiphysis morphology J:202147
abnormal long bone hypertrophic chondrocyte zone J:202147
abnormal osteoclast differentiation J:202147
abnormal skeleton development J:202147
abnormal trabecular bone morphology J:202147
anemia J:202147
decreased body weight J:202147
decreased bone mass J:202147
decreased bone mineral density J:202147
decreased bone trabecula number J:202147
decreased cell proliferation J:202147
decreased chondrocyte number J:202147
decreased circulating interleukin-5 level J:202147
decreased circulating interleukin-12b level J:202147
decreased compact bone area J:202147
decreased compact bone thickness J:202147
decreased erythrocyte cell number J:202147
decreased femur size J:202147
decreased lymphocyte cell number J:202147
decreased trabecular bone mass J:202147
decreased trabecular bone thickness J:202147
decreased width of hypertrophic chondrocyte zone J:202147
disorganized long bone epiphyseal plate J:202147
normal immune system phenotype J:202147
increased bone resorption J:202147
increased circulating interleukin-1 beta level J:202147
increased circulating interleukin-3 level J:202147
increased circulating interleukin-4 level J:202147
increased circulating interleukin-6 level J:202147
increased circulating interleukin-9 level J:202147
increased circulating interleukin-13 level J:202147
increased circulating interleukin-18 level J:202147
increased circulating tumor necrosis factor level J:202147
increased granulocyte number J:202147
increased inflammatory response J:202147
increased interferon-gamma secretion J:202147
increased interleukin-1 beta secretion J:202147
increased lymphocyte cell number J:202147
increased monocyte cell number J:202147
increased neutrophil cell number J:202147
increased osteoclast cell number J:202147
joint inflammation J:202147
meningitis J:202147
osteomyelitis J:202147
postnatal growth retardation J:202147
postnatal lethality, complete penetrance J:202147
thrombocytosis J:202147
Nlrp3tm3Hhf/Nlrp3tm3Hhf
B6N.129-Nlrp3tm3Hhf 		no abnormal phenotype detected J:180878
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory