Nlrp3^M9Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nlrp3^M9Btlr
• Name: NLR family, pyrin domain containing 3; mutation 9, Bruce Beutler
• MGI ID: MGI:5632190
• Synonyms: Park6
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^M9Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a a T to G transition at base pair 59,549,036 (Build 38) on Chromosome 11, or base pair 7,468 in the GenBank genomic region NC_000077. This site corresponds to nucleotide 1,664 in the mRNA sequence NM_145827, within exon 4 of 10 total exons. The mutation results in a phenylalanine (F) to valine (V) substitution at amino acid position 480 (F480V) of the protein. (J:220071)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 69 strains or lines available

References

• Original: J:220071 Shi H, et al., Mutagenetix entry for Park6 (Updated on April 7, 2015). MGI Direct Data Submission. 2015
• All: 1 reference(s)