Nlrp3^m12Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nlrp3^m12Btlr
• Name: NLR family, pyrin domain containing 3; mutation 12, Bruce Beutler
• MGI ID: MGI:6284017
• Synonyms: flogiston
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^m12Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-mutagenesis induced an A to T transversion at base pair 59,558,448 (v38) on chromosome 11, or base pair 16,880 in the GenBank genomic region NC_000077. The mutation corresponds to residue 2,781 in the mRNA sequence NM_145827 within exon 7 of 10 total exons. The mutated nucleotide is indicated in red. The mutation results in a histidine to leucine substitution at position 852 (H852L) in the NLRP3 protein. (J:272150)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 61 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3795

References

• Original: J:272150 Shi H, et al., Mutagenetix entry for flogiston. MGI Direct Data Submission. 2019
• All: 1 reference(s)