Nlrp3^tm1Vmd
Targeted Allele Detail

Summary

• Symbol: Nlrp3^tm1Vmd
• Name: NLR family, pyrin domain containing 3; targeted mutation 1, Vishva M Dixit
• MGI ID: MGI:3622094
• Synonyms: Cias1^-, Nalp3^-
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^tm1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106976
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3 were replaced with a neomycin resistance cassette. Exon 3 contains the ATG and the entire pyrin domain; exons 1 and 2 encode the 5' UTR. RT-PCR failed to detect transcript in mutants. (J:106976)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 61 strains or lines available

References

• Original: J:106976 Mariathasan S, et al., Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006 Mar 9;440(7081):228-32
• All: 132 reference(s)