All Phenotypes Nlrp3<tm1Vmd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nlrp3^tm1Vmd
targeted mutation 1, Vishva M Dixit
MGI:3622094

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrp3^tm1Vmd/Nlrp3^tm1Vmd	B6.B6N-Nlrp3^tm1Vmd	MGI:5468973
hm2	Nlrp3^tm1Vmd/Nlrp3^tm1Vmd	involves: C57BL/6N	MGI:3625288
cx3	Nlrc4^tm1Vmd/Nlrc4^tm1Vmd Nlrp3^tm1Vmd/Nlrp3^tm1Vmd	C57BL/6-Nlrp3^tm1Vmd Nlrc4^tm1Vmd	MGI:5428938
cx4	Nlrc4^em2Vnce/Nlrc4^em2Vnce Nlrp3^tm1Vmd/Nlrp3^tm1Vmd	involves: C57BL/6J * C57BL/6N	MGI:6509152
cx5	Nlrc4^em1Vnce/Nlrc4^em1Vnce Nlrp3^tm1Vmd/Nlrp3^tm1Vmd	involves: C57BL/6J * C57BL/6N	MGI:6509153
cx6	Del(13Naip1-Naip5)1Vnce/Del(13Naip1-Naip5)1Vnce Nlrp3^tm1Vmd/Nlrp3^tm1Vmd	involves: C57BL/6J * C57BL/6N	MGI:6509155

Allelic Composition	Nlrp3^tm1Vmd/Nlrp3^tm1Vmd
Genetic Background	B6.B6N-Nlrp3^tm1Vmd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^tm1Vmd mutation (0 available); any Nlrp3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:294930 )

N	• normal inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased interleukin-1 beta secretion ( J:193522 )

• from LPS-primed bone marrow-derived macrophages stimulated with E. coli, C. rodentium and C. cholerae

decreased susceptibility to endotoxin shock ( J:193522 )

• mice treated with LPS challenge in a model of acute septic shock exhibit reduced serum levels of IL1b and IL18 compared with controls

• however, mice do not survive beyond 20 hours and serum levels of IL1a are increased

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

Allelic Composition	Nlrp3^tm1Vmd/Nlrp3^tm1Vmd
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^tm1Vmd mutation (0 available); any Nlrp3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine secretion ( J:106976 )

• unlike macrophages from wild-type mice, macrophages from Cias1-deficient mice do not release significant amounts of Il-1beta or Il-18 when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+

• null mice secrete much lower serum levels of Il-1beta and Il-18 after receiving a lethal LPS dose

decreased susceptibility to endotoxin shock ( J:106976 )

• in response to a lethal dose of LPS, all injected wild-type mice die within 48 hours of caspase-1-dependent endotoxic shock, but only 30% of Cias-null mice die after 72 hours

abnormal response to infection ( J:106976 )

• macrophages from null mice show reduced Il-1beta and Il-18 release and no caspase-1 activation when infected with S. aureus or Listeria compared to wild-type macrophages in culture

• S. aureus infection induces more macrophage death in cells from null animals compared to wild-type macrophages in culture

Allelic Composition	Nlrc4^tm1Vmd/Nlrc4^tm1Vmd Nlrp3^tm1Vmd/Nlrp3^tm1Vmd
Genetic Background	C57BL/6-Nlrp3^tm1Vmd Nlrc4^tm1Vmd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4^tm1Vmd mutation (1 available); any Nlrc4 mutation (46 available)
Nlrp3^tm1Vmd mutation (0 available); any Nlrp3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:160545 )

• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium

Allelic Composition	Nlrc4^em2Vnce/Nlrc4^em2Vnce Nlrp3^tm1Vmd/Nlrp3^tm1Vmd
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4^em2Vnce mutation (1 available); any Nlrc4 mutation (46 available)
Nlrp3^tm1Vmd mutation (0 available); any Nlrp3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased lactate dehydrogenase level ( J:294930 )

• 40-50% reduction in LDH released by bone marrow derived macrophages (BMDMs) exposed to low doses of cytosolic Legionella pneumophila flagellin whether primed with LPS or not

immune system

decreased inflammatory response ( J:294930 )

• significantly reduced inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin whether primed with LPS or not

• severely reduced inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium

Allelic Composition	Nlrc4^em1Vnce/Nlrc4^em1Vnce Nlrp3^tm1Vmd/Nlrp3^tm1Vmd
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4^em1Vnce mutation (0 available); any Nlrc4 mutation (46 available)
Nlrp3^tm1Vmd mutation (0 available); any Nlrp3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased lactate dehydrogenase level ( J:294930 )

• severe reduction in LDH released by bone marrow derived macrophages exposed to Salmonella Typhimurium

immune system

decreased inflammatory response ( J:294930 )

• severe reduction in inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium

Allelic Composition	Del(13Naip1-Naip5)1Vnce/Del(13Naip1-Naip5)1Vnce Nlrp3^tm1Vmd/Nlrp3^tm1Vmd
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13Naip1-Naip5)1Vnce mutation (2 available); any Del(13Naip1-Naip5)1Vnce mutation (1 available)
Nlrp3^tm1Vmd mutation (0 available); any Nlrp3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased lactate dehydrogenase level ( J:294930 )

• severe reduction in LDH released by bone marrow derived macrophages exposed to Salmonella Typhimurium

immune system

decreased inflammatory response ( J:294930 )

• severe reduction in inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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