Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Vmd mutation
(0 available);
any
Nlrp3 mutation
(61 available)
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immune system
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N |
• normal inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin
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• in response to LPS challenge in a model of acute septic shock
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• in response to LPS challenge in a model of acute septic shock
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• from LPS-primed bone marrow-derived macrophages stimulated with E. coli, C. rodentium and C. cholerae
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• mice treated with LPS challenge in a model of acute septic shock exhibit reduced serum levels of IL1b and IL18 compared with controls
• however, mice do not survive beyond 20 hours and serum levels of IL1a are increased
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Vmd mutation
(0 available);
any
Nlrp3 mutation
(61 available)
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immune system
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• unlike macrophages from wild-type mice, macrophages from Cias1-deficient mice do not release significant amounts of Il-1beta or Il-18 when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+
• null mice secrete much lower serum levels of Il-1beta and Il-18 after receiving a lethal LPS dose
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• in response to a lethal dose of LPS, all injected wild-type mice die within 48 hours of caspase-1-dependent endotoxic shock, but only 30% of Cias-null mice die after 72 hours
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• macrophages from null mice show reduced Il-1beta and Il-18 release and no caspase-1 activation when infected with S. aureus or Listeria compared to wild-type macrophages in culture
• S. aureus infection induces more macrophage death in cells from null animals compared to wild-type macrophages in culture
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Vmd mutation
(1 available);
any
Nlrc4 mutation
(67 available)
Nlrp3tm1Vmd mutation
(0 available);
any
Nlrp3 mutation
(61 available)
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immune system
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• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em2Vnce mutation
(1 available);
any
Nlrc4 mutation
(67 available)
Nlrp3tm1Vmd mutation
(0 available);
any
Nlrp3 mutation
(61 available)
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homeostasis/metabolism
immune system
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• significantly reduced inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin whether primed with LPS or not
• severely reduced inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em1Vnce mutation
(0 available);
any
Nlrc4 mutation
(67 available)
Nlrp3tm1Vmd mutation
(0 available);
any
Nlrp3 mutation
(61 available)
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homeostasis/metabolism
immune system
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• severe reduction in inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13Naip1-Naip5)1Vnce mutation
(2 available);
any
Del(13Naip1-Naip5)1Vnce mutation
(1 available)
Nlrp3tm1Vmd mutation
(0 available);
any
Nlrp3 mutation
(61 available)
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homeostasis/metabolism
immune system
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• severe reduction in inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium
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Analysis Tools