Nlrp3^em1Taoli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nlrp3^em1Taoli
• Name: NLR family, pyrin domain containing 3; endonuclease-mediated mutation 1, Tao Li
• MGI ID: MGI:7545524
• Synonyms: Nlrp3^-
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^em1Taoli page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted a portion of the genome to generated a null allele. (J:251887)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 69 strains or lines available

References

• Original: J:251887 Song N, et al., NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Mol Cell. 2017 Oct 5;68(1):185-197.e6
• All: 3 reference(s)