Nlrp3^M8Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nlrp3^M8Btlr
• Name: NLR family, pyrin domain containing 3; mutation 8, Bruce Beutler
• MGI ID: MGI:5613597
• Synonyms: Park5
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^M8Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion at base pair 59,548,476 (v38) on chromosome 11, or base pair 6,908 in the GenBank genomic region NC_000077. The mutation corresponds to residue 1,104 in the mRNA sequence NM_145827 within exon 4 of 10 total exons. The mutation results in an isoleucine (I) to asparagine (N) substitution at position 293 (I293N) in the protein, and is strongly predicted by Polyphen-2 to cause loss of function (score = 0.991). (J:217294)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 69 strains or lines available

References

• Original: J:217294 Shi H, et al., Mutagenetix entry for Park5. Updated on January 23, 2015. MGI Direct Data Submission. 2015
• All: 1 reference(s)