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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3M8Btlr
mutation 8, Bruce Beutler
MGI:5613597
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp3M8Btlr/Nlrp3M8Btlr C57BL/6J-Nlrp3M8Btlr MGI:5613604
ht2
 		Nlrp3M8Btlr/Nlrp3+ C57BL/6J-Nlrp3M8Btlr MGI:5613605


Genotype
MGI:5613604
hm1
Allelic
Composition		 Nlrp3M8Btlr/Nlrp3M8Btlr
Genetic
Background		 C57BL/6J-Nlrp3M8Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M8Btlr mutation (0 available); any Nlrp3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:217294 )
• in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment




Genotype
MGI:5613605
ht2
Allelic
Composition		 Nlrp3M8Btlr/Nlrp3+
Genetic
Background		 C57BL/6J-Nlrp3M8Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M8Btlr mutation (0 available); any Nlrp3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:217294 )
• in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory