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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptpmt1
protein tyrosine phosphatase, mitochondrial 1
MGI:1913711
26 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Ptpmt1tm1.1(KOMP)Vlcg/\Ptpmt1tm1.1(KOMP)Vlcg
C57BL/6N-Ptpmt1tm1.1(KOMP)Vlcg/Ucd 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
\Ptpmt1tm1.1Jedi/\Ptpmt1tm1.1Jedi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal aerobic respiration J:176087
abnormal cell physiology J:176087
abnormal mitochondrial morphology J:176087
decreased cell proliferation J:176087
\Ptpmt1tm1.2Jedi/\Ptpmt1tm1.2Jedi
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL 		embryonic lethality between implantation and placentation, complete penetrance J:176087
\Ptpmt1tm1Ckq/\Ptpmt1tm1Ckq
B6.Cg-Ptpmt1tm1Ckq 		absent inner cell mass proliferation J:178313
disorganized embryonic tissue J:178313
embryonic growth retardation J:178313
embryonic lethality between implantation and somite formation, complete penetrance J:178313
increased embryonic tissue cell apoptosis J:178313
\Ptpmt1tm2.1Ckq/\Ptpmt1tm2.1Ckq
\Cd19tm1(cre)Cgn/\Cd19+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL 		normal hematopoietic system phenotype J:194929
normal immune system phenotype J:194929
\Ptpmt1tm2.1Ckq/\Ptpmt1tm2.1Ckq
\Lyz2tm1(cre)Ifo/\Lyz2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL 		abnormal aerobic respiration J:194929
normal hematopoietic system phenotype J:194929
normal immune system phenotype J:194929
\Ptpmt1tm2.1Ckq/\Ptpmt1tm2.1Ckq
\Tg(Lck-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL 		normal hematopoietic system phenotype J:194929
normal immune system phenotype J:194929
\Ptpmt1tm2.1Ckq/\Ptpmt1tm2.1Ckq
\Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL 		abnormal common lymphocyte progenitor cell morphology J:194929
abnormal hematopoietic stem cell physiology J:194929
anemia J:194929
decreased common myeloid progenitor cell number J:194929
normal hematopoietic system phenotype J:194929
increased hematopoietic stem cell number J:194929
pancytopenia J:194929
premature death J:194929
\Ptpmt1tm2.1Ckq/\Ptpmt1tm2.1Ckq
\Tg(VAV1-cre)1Graf/0
involves: 129S6/SvEvTac * C57BL/6J * SJL 		anemia J:194929
decreased bone marrow cell number J:194929
impaired hematopoiesis J:194929
increased hematopoietic stem cell number J:194929
pancytopenia J:194929
postnatal lethality, complete penetrance J:194929
small spleen J:194929
small thymus J:194929
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory