Ptpmt1^tm1Ckq
Targeted Allele Detail

Summary

• Symbol: Ptpmt1^tm1Ckq
• Name: protein tyrosine phosphatase, mitochondrial 1; targeted mutation 1, Cheng-Kui Qu
• MGI ID: MGI:5300821
• Synonyms: Ptpmt1^-
• Gene: Ptpmt1 Location: Chr2:90741057-90748395 bp, - strand Genetic Position: Chr2, 50.44 cM, cytoband E1
• Alliance: Ptpmt1^tm1Ckq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178313
• Parent Cell Line: D1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette via homologous recombination. Western blot analysis indicated an approximately 50% reduction in protein expression in heterozygous embryonic stem cells. (J:178313)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpmt1 Mutation: 12 strains or lines available

References

• Original: J:178313 Shen J, et al., A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol. 2011 Dec;31(24):4902-16
• All: 1 reference(s)