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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptpmt1tm1Ckq
targeted mutation 1, Cheng-Kui Qu
MGI:5300821
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptpmt1tm1Ckq/Ptpmt1tm1Ckq B6.Cg-Ptpmt1tm1Ckq MGI:5300823


Genotype
MGI:5300823
hm1
Allelic
Composition
Ptpmt1tm1Ckq/Ptpmt1tm1Ckq
Genetic
Background
B6.Cg-Ptpmt1tm1Ckq
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpmt1tm1Ckq mutation (0 available); any Ptpmt1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• extensive apoptosis at E6.5
• markedly increased apoptotic cells in mutant embryos and ectoplacental cones at E7.5
• the inner cell mass of cultured blastocysts gradually stop growing and die after 6 days in culture
• unable to establish embryonic stem cell clones from blastocysts
• severely retarded with embryos at E7.5 resembling early stage blastocysts

cellular
• extensive apoptosis at E6.5
• markedly increased apoptotic cells in mutant embryos and ectoplacental cones at E7.5
• the inner cell mass of cultured blastocysts gradually stop growing and die after 6 days in culture
• unable to establish embryonic stem cell clones from blastocysts

growth/size/body
• severely retarded with embryos at E7.5 resembling early stage blastocysts





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory