Ptpmt1^tm2.1Ckq
Targeted Allele Detail

Summary

• Symbol: Ptpmt1^tm2.1Ckq
• Name: protein tyrosine phosphatase, mitochondrial 1; targeted mutation 2.1, Cheng-Kui Qu
• MGI ID: MGI:5300822
• Synonyms: PTPMT1^fl, Ptpmt1^flox
• Gene: Ptpmt1 Location: Chr2:90741057-90748395 bp, - strand Genetic Position: Chr2, 50.44 cM, cytoband E1
• Alliance: Ptpmt1^tm2.1Ckq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178313
• Parent Cell Line: D1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 1 through 3 floxed. (J:178313, J:194929)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpmt1 Mutation: 12 strains or lines available

References

• Original: J:178313 Shen J, et al., A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol. 2011 Dec;31(24):4902-16
• All: 3 reference(s)