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Irs1 Gene Detail
Summary
  • Symbol
    Irs1
  • Name
    insulin receptor substrate 1
  • Synonyms
    G972R, IRS-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99454
    NCBI Gene: 16367
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:82210822-82269137 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 42.00 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    400 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99454
 protein coding gene Chr1:82210822-82269160 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016213
 protein coding gene Chr1:83141762-83200925 (-)
A/J MGP_AJ_G0016196
 protein coding gene Chr1:80181999-80246727 (-)
AKR/J MGP_AKRJ_G0016153
 protein coding gene Chr1:82369986-82436506 (-)
BALB/cJ MGP_BALBcJ_G0016151
 protein coding gene Chr1:80268788-80327372 (-)
C3H/HeJ MGP_C3HHeJ_G0015981
 protein coding gene Chr1:82753960-82814460 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016604
 protein coding gene Chr1:86344306-86404098 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014324
 protein coding gene Chr1:75425019-75484456 (-)
CAST/EiJ MGP_CASTEiJ_G0015568
 protein coding gene Chr1:82218187-82224989 (-)
CBA/J MGP_CBAJ_G0015955
 protein coding gene Chr1:89114856-89178672 (-)
DBA/2J MGP_DBA2J_G0016056
 protein coding gene Chr1:79480699-79543265 (-)
FVB/NJ MGP_FVBNJ_G0016059
 protein coding gene Chr1:78593365-78651516 (-)
LP/J MGP_LPJ_G0016129
 protein coding gene Chr1:84271279-84334134 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016079
 protein coding gene Chr1:92527592-92589304 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016651
 protein coding gene Chr1:82552106-82613115 (-)
PWK/PhJ MGP_PWKPhJ_G0015353
 protein coding gene Chr1:78977924-78984720 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015130
 protein coding gene Chr1:81754828-81815725 (-)
WSB/EiJ MGP_WSBEiJ_G0015627
 protein coding gene Chr1:82328345-82390437 (-)



Homology
more
  • Human Ortholog
    IRS1, insulin receptor substrate 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRS1, insulin receptor substrate 1
  • Synonyms
    HIRS-1
  • Links
    NCBI Gene ID: 3667
    neXtProt AC: NX_P35568
    UniProt: P35568

  • Chr Location
    2q36.3; chr2:226731317-226798790 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Irs1 mouse models; 3 with human IRS1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    65 phenotypes from 11 alleles in 13 genetic backgrounds
    38 phenotypes from multigenic genotypes
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit 50 percent reductions in body weights at birth and at 4 months of age, impaired glucose tolerance, and mild insulin and IGF-1 resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    97
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    50
  • cDNA Data
    12
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055980 Ensembl Gene Model | MGI Sequence Detail 58316 C57BL/6J ±  kb
    transcript ENSMUST00000069799 Ensembl | MGI Sequence Detail 9144 Not Applicable  
    polypeptide ENSMUSP00000063795 Ensembl | MGI Sequence Detail 1231 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 7
      cDNA 12
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16223
    References
    more
    • Summaries
      All 266
      Developmental Gene Expression 15
      Diseases 4
      Gene Ontology 32
      Phenotypes 114
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:330376 Riehle C, et al., Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart. Mol Cell Biol. 2022 Oct 20;42(10):e0016322
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    01/24/2023
    MGI 6.22     		The Jackson Laboratory