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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irs1
insulin receptor substrate 1
MGI:99454
34 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxo1tm1Rdp/Foxo1tm1Rdp
Irs1tm1Mfw/Irs1tm1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB 		abnormal triglyceride level J:137845
decreased circulating cholesterol level J:137845
decreased circulating free fatty acids level J:137845
decreased circulating HDL cholesterol level J:137845
decreased circulating triglyceride level J:137845
normal homeostasis/metabolism phenotype J:137845
Gcktm1Tka/Gck+
Irs1tm1Tka/Irs1tm1Tka
involves: 129X1/SvJ * C57BL/6 * CBA * ICR 		decreased body weight J:38899
impaired glucose tolerance J:38899
increased circulating insulin level J:38899
increased pancreatic beta cell mass J:38899
insulin resistance J:38899
pancreatic islet hyperplasia J:38899
postnatal growth retardation J:38899
Irs1smla/Irs1smla
Serpinb2tm2Dgi/Serpinb2tm2Dgi
involves: 129S2/SvPas * C57BL/6J * DBA/2J 		decreased birth body size J:164568
decreased body height J:164568
decreased body size J:52283, J:164568
decreased body weight J:164568
muscular atrophy J:164568
postnatal lethality J:164568
premature death J:164568
Irs1tm1Jos/Irs1+
Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal pancreatic beta cell morphology J:93415
decreased body weight J:93415
decreased circulating insulin level J:93415
hyperglycemia J:93415
Irs1tm1Jos/Irs1tm1Jos
Irs3tm1Lhd/Irs3tm1Lhd
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		abnormal gonadal fat pad morphology J:80976
decreased circulating free fatty acids level J:80976
decreased circulating leptin level J:80976
decreased circulating triglyceride level J:80976
decreased triglyceride level J:80976
decreased white adipose tissue amount J:80976
hyperglycemia J:80976
impaired glucose tolerance J:80976
increased circulating insulin level J:80976
increased pancreatic beta cell mass J:80976
insulin resistance J:80976
normal liver/biliary system phenotype J:80976
normal mortality/aging J:80976
pancreatic islet hyperplasia J:80976
postnatal growth retardation J:80976
Irs1tm1Jos/Irs1tm1Jos
Irs4tm1Lhd/Y
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		impaired glucose tolerance J:80976
increased circulating insulin level J:80976
insulin resistance J:80976
postnatal growth retardation J:80976
Irs1tm1Jos/Irs1tm1Jos
Irs4tm1Lhd/Irs4tm1Lhd
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		impaired glucose tolerance J:80976
increased circulating insulin level J:80976
insulin resistance J:80976
postnatal growth retardation J:80976
Irs1tm1Mfw/Irs1+
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N 		impaired glucose tolerance J:156999
Irs1tm1Mfw/Irs1tm1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		abnormal triglyceride level J:137845
decreased body size J:137845
decreased circulating cholesterol level J:137845
decreased circulating free fatty acids level J:137845
decreased circulating HDL cholesterol level J:137845
decreased circulating triglyceride level J:137845
decreased liver glycogen level J:137845
hyperglycemia J:137845
impaired glucose tolerance J:137845
increased circulating glucose level J:137845
increased circulating insulin level J:137845
increased susceptibility to autoimmune diabetes J:137845
insulin resistance J:137845
Irs1tm1Mfw/Irs1tm2.1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N 		impaired glucose tolerance J:156999
increased circulating insulin level J:156999
insulin resistance J:156999
Irs1tm1Tka/Irs1tm1Tka
Irs2tm1Tka/Irs2tm1Tka
involves: C57BL/6 * CBA 		abnormal cell differentiation J:68004
decreased white adipose tissue amount J:68004
Irs1tm2.1Mfw/Irs1tm2.1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N 		impaired glucose tolerance J:156999
increased circulating insulin level J:156999
Irs1tm2Tka/Irs1tm2Tka
Irs2tm2Tka/Irs2tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA 		increased susceptibility to autoimmune diabetes J:137846
insulin resistance J:137846
Irs1tm3.1Mfw/Irs1tm3.1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		decreased body length J:156999
decreased body weight J:156999
decreased bone mineral density J:156999
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory