Phenotypes Associated with This Genotype

Genotype
MGI:3510670

• Allelic Composition: Irs1^tm1Jos/Irs1⁺; Irs2^tm2Mfw/Irs2^tm2Mfw; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:93415 )

• at 6 months beta cell content is decreased 8-fold

growth/size/body

decreased body weight ( J:93415 )

homeostasis/metabolism

hyperglycemia ( J:93415 )

• diabetes and progressive severe hyperglycemia are seen starting at 4 weeks of age

decreased circulating insulin level ( J:93415 )

• severe, progressive hypoinsulinemia is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:93415