Phenotypes Associated with This Genotype

Genotype
MGI:2174965

• Allelic Composition: Irs1^tm1Tka/Irs1^tm1Tka
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

abnormal postnatal growth/weight/body size ( J:21373 )

decreased body weight ( J:21373 )

• at 3, 8, and 15 weeks, the weights of homozygotes are ~30% less than those of wild-type or heterozygous littermates

postnatal growth retardation ( J:21373 )

• homozygotes are viable and fertile but exhibit a growth retardation at 3, 8, and 15 weeks of age

decreased fetal weight ( J:21373 )

• at E18.5, the weights of homozygotes are ~80% of those of wild-type or heterozygous controls

fetal growth retardation ( J:21373 )

• at E15.5, homozygotes display growth retardation relative to wild-type controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:21373 )

N • homozygotes display normal serum IGF1, IGF2 and growth hormone levels relative to wild-type mice

abnormal glucose homeostasis ( J:21373 )

• homozygotes maintain normal fasting glucose and glucose tolerance (by compensatory beta-cell hyperplasia)

• homozygotes exhibit a higher basal glucose transport of adipocytes relative to wild-type mice; in contrast, insulin-stimulated glucose transport of mutant adipocytes is significantly impaired

increased circulating insulin level ( J:21373 )

• the serum insulin levels of homozygotes before and after glucose load are significantly higher than those of wild-type and heterozygous mutant mice

insulin resistance ( J:21373 )

• homozygotes exhibit a mild to moderate insulin, IGF1, and IGF2 resistance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:21373