Symbol
Name
ID

Irs1
insulin receptor substrate 1
MGI:99454

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance
Disease(s) Associated with IRS1	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance
coronary artery disease
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal vascular wound healing

decreased insulin secretion

decreased circulating glucose level

increased circulating insulin level

decreased circulating HDL cholesterol level

increased circulating free fatty acids level

increased circulating triglyceride level

abnormal glucose homeostasis

impaired glucose tolerance

insulin resistance

abnormal lipid level

impaired lipolysis

abnormal bone healing

Availability

Mouse Genotype

Irs1^m1Btlr/Irs1^m1Btlr

Irs1^Sml/Irs1^Sml

Irs1^tm1Jos/Irs1^tm1Jos

Irs1^tm1Tka/Irs1^tm1Tka

Irs1^tm2.1Mfw/Irs1^tm2.1Mfw

Irs1^Sml/Irs1⁺

Irs1^tm2.1Mfw/Irs1⁺

Irs1^tm1Mfw/Irs1^tm1Mfw
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Irs1^tm2Tka/Irs1^tm2Tka
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23