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Ar Gene Detail
Summary
  • Symbol
    Ar
  • Name
    androgen receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88064
    NCBI Gene: 11835
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:97192375-97366821 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 42.82 cM
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    492 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88064
protein coding gene ChrX:97192363-97366824 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035931
protein coding gene ChrX:94519451-94700407 (+)
A/J MGP_AJ_G0035916
protein coding gene ChrX:94631610-94809631 (+)
AKR/J MGP_AKRJ_G0035832
protein coding gene ChrX:97292110-97471900 (+)
BALB/cJ MGP_BALBcJ_G0035899
protein coding gene ChrX:93407432-93578928 (+)
C3H/HeJ MGP_C3HHeJ_G0035608
protein coding gene ChrX:94992285-95167427 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036428
protein coding gene ChrX:97458294-97643128 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033258
protein coding gene ChrX:92480947-92650344 (+)
CAST/EiJ MGP_CASTEiJ_G0034895
protein coding gene ChrX:79328711-79503668 (+)
CBA/J MGP_CBAJ_G0035583
protein coding gene ChrX:100460337-100628022 (+)
DBA/2J MGP_DBA2J_G0035737
protein coding gene ChrX:93888415-94059222 (+)
FVB/NJ MGP_FVBNJ_G0035675
protein coding gene ChrX:93271509-93443758 (+)
LP/J MGP_LPJ_G0035827
protein coding gene ChrX:95537760-95715093 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035710
protein coding gene ChrX:104895192-105106596 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036455
protein coding gene ChrX:94291304-94467544 (+)
PWK/PhJ MGP_PWKPhJ_G0034594
protein coding gene ChrX:77021615-77190976 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034422
protein coding gene ChrX:80192320-80361924 (+)
WSB/EiJ MGP_WSBEiJ_G0035034
protein coding gene ChrX:92998626-93174570 (+)



Homology
more
  • Human Ortholog
    AR, androgen receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AR, androgen receptor
  • Synonyms
    AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
  • Links
    NCBI Gene ID: 367
    neXtProt AC: NX_P10275
    UniProt: P10275

  • Chr Location
    Xq12; chrX:67544021-67730619 (+)  GRCh38

  • MGI Vertebrate Homology
    Ar stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: AR
  • Gene Tree
    Ar
Human Diseases
more
  • Diseases
    3 with Ar mouse models; 13 with human AR associations

Human Disease Mouse Models
      
IDs
View 8 models
IDs
View 1 model
      
IDs
View 1 model
      
IDs
IDs
IDs
View 1 model
IDs
IDs
IDs
View 1 model
IDs
IDs
IDs
IDs
View 4 models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    9 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    166 phenotypes from 16 alleles in 33 genetic backgrounds
    84 phenotypes from multigenic genotypes
    4 images
    356 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous mutant males are androgen-resistant and therefore have small, undescended testes, and lack epididymal structures, vas deferens, and male accessory glands. They resemble females physically and behaviorally, but lack female reproductive organs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046532 Ensembl Gene Model | MGI Sequence Detail 174447 C57BL/6J ±  kb
    transcript ENSMUST00000052837 Ensembl | MGI Sequence Detail 10048 Not Applicable  
    polypeptide ENSMUSP00000052648 Ensembl | MGI Sequence Detail 899 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 14
      cDNA 32
      Primer pair 13
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1384, MGD-MRK-15046, MGI:2148007
    References
    more
    • Summaries
      All 641
      Developmental Gene Expression 101
      Diseases 12
      Gene Ontology 42
      Phenotypes 356
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:346196 Ubba V, et al., Reproductive Profile of Neuronal Androgen Receptor Knockout Female Mice With a Low Dose of DHT. Endocrinology. 2024 Jan 16;165(3)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    04/02/2024
    MGI 6.23
    The Jackson Laboratory