Insl3^tm1Imad
Targeted Allele Detail

Summary

• Symbol: Insl3^tm1Imad
• Name: insulin-like 3; targeted mutation 1, Ibrahim M Adham
• MGI ID: MGI:2661997
• Synonyms: Insl3^-, Leyl^-
• Gene: Insl3 Location: Chr8:72141896-72143221 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Insl3^tm1Imad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83429
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 2 exons that comprise the gene were replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of testicular mRNA obtained from homozygous mutant males. (J:83429)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insl3 Mutation: 7 strains or lines available

References

• Original: J:83429 Zimmermann S, et al., Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol Endocrinol. 1999 May;13(5):681-91
• All: 7 reference(s)