Analysis ToolsMouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cryptorchidism | DOID:11383 |
OMIM:219050 |
J:83429 | |
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Allele Symbol Allele Name Allele ID |
Insl3tm1Imad targeted mutation 1, Ibrahim M Adham MGI:2661997 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cryptorchidism | DOID:11383 |
OMIM:219050 |
J:83429 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal copulatory behavior
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• observed at 2 weeks of age
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 |
• bilateral cryptorchism with testes resting high in the abdomen
• the right testicle of some males was in the contralateral position
• lack of tight attachment to the inguinal region and regression of the cranial suspensory ligament
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• observed at 2 weeks of age
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• absence of postmeiotic cells at 3 months of age
• surgical correction of cryptorchism rescued spermatogenesis, indicating the observed defects may be due to increased the temperature of the abdominal cavity
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• the gubernacular bulbs were similar to those wild-type prior to transabdominal descent of the testes (E15.5)
• the gubernacular bulbs are poorly developed relative to wild-type males and resemble those of wild-type females at E17.5
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• Mullerian duct derivatives were absent
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• male infertility, however female fertility was normal as females produced litters of normal size and exhibited normal oestrus cylces
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|
|
• bilateral cryptorchism with testes resting high in the abdomen
• the right testicle of some males was in the contralateral position
• lack of tight attachment to the inguinal region and regression of the cranial suspensory ligament
|
|
• the gubernacular bulbs were similar to those wild-type prior to transabdominal descent of the testes (E15.5)
• the gubernacular bulbs are poorly developed relative to wild-type males and resemble those of wild-type females at E17.5
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cryptorchidism | DOID:11383 |
OMIM:219050 |
J:83429 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• Mullerian duct derivatives were absent
|
|
|
• there is no tight attachment of the testes to the inguinal region
|
|
|
• bilateral cryptorchism with testes situated adjacent to the kidneys
• lack of tight attachment to the inguinal region
• testes were attached to the dorsal abdominal wall by well developed cranial suspsensory ligaments
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|
• the epididymis was absent
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• the vas deferens was absent
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• the male external and internal genitalia are not virilized
|
|
|
• bilateral cryptorchism with testes situated adjacent to the kidneys
• lack of tight attachment to the inguinal region
• testes were attached to the dorsal abdominal wall by well developed cranial suspsensory ligaments
|
|
|
• there is no tight attachment of the testes to the inguinal region
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cryptorchidism | DOID:11383 |
OMIM:219050 |
J:83429 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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