Phenotypes Associated with This Genotype

Genotype
MGI:3815199

• Allelic Composition: Ar^Tfm/Y
• Genetic Background: involves: NMRI * STOCK Eda^Ta Atp7a^Mo-blo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

arrest of male meiosis ( J:140803 )

• spermatogenesis does not proceed beyond meiosis prophase

abnormal seminiferous tubule morphology ( J:140803 )

• Background Sensitivity: mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to Ar^Tfm male mice on the original stock background

enlarged seminiferous tubules ( J:140803 )

• Background Sensitivity: in 15 of 46 mice unlike Ar^Tfm male mice on the original stock background

increased Leydig cell number ( J:140803 )

• Background Sensitivity: unlike Ar^Tfm male mice on the original stock background

cryptorchism ( J:140803 )

increased testis tumor incidence ( J:140803 )

• Background Sensitivity: 4 of 46 mice exhibit unilateral Leydig tumor unlike Ar^Tfm male mice on the original stock background

• however, no germ cell tumors are observed

secondary sex reversal ( J:140803 )

• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts

neoplasm

increased testis tumor incidence ( J:140803 )

• Background Sensitivity: 4 of 46 mice exhibit unilateral Leydig tumor unlike Ar^Tfm male mice on the original stock background

• however, no germ cell tumors are observed

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:140803 )

• Background Sensitivity: mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to Ar^Tfm male mice on the original stock background

enlarged seminiferous tubules ( J:140803 )

• Background Sensitivity: in 15 of 46 mice unlike Ar^Tfm male mice on the original stock background

increased Leydig cell number ( J:140803 )

• Background Sensitivity: unlike Ar^Tfm male mice on the original stock background

cryptorchism ( J:140803 )

increased testis tumor incidence ( J:140803 )

• Background Sensitivity: 4 of 46 mice exhibit unilateral Leydig tumor unlike Ar^Tfm male mice on the original stock background

• however, no germ cell tumors are observed

cellular

arrest of male meiosis ( J:140803 )

• spermatogenesis does not proceed beyond meiosis prophase

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
androgen insensitivity syndrome		DOID:4674	OMIM:300068	J:140803