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Transgene Detail
Symbol: Tg(TRAMP)8247Ng
Name: transgene insertion 8247, Norman M Greenberg
MGI ID: MGI:2384595
Synonyms: PB-Tag, probasin/Tag, Tg(Pbsn-TAg)8247Ng, TRAMP
Transgene: Tg(TRAMP)8247Ng  Location: unknown  Genetic Position: Chr16, Syntenic
Alliance: Tg(TRAMP)8247Ng page
Histological analysis of prostate tumors in Tg(TRAMP)8247Ng/0 mice

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsExpression of the SV40 early region tumor antigen was driven in mouse prostate epithelium via a rat probasin promoter region fragment (-426/+28 bp). Sequencing identified greater than 20 copies of the Tg(TRAMP)8247Ng transgene (hemizygous) integrated on chromosome 16 (~18,993,000-19,272,880; mouse mm10). The region surrounding the integration site has duplicated. Currently, there are no genes annotated in this region. (J:65303, J:73560)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Tg(TRAMP)8247Ng
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
TRAMP stands for TRansgenic Adenocarcinoma Mouse Prostate. Lines 5666 and 8079 were also produced.

Transgenic mice on a C57BL6 background develop progressive forms of prostate cancer with distant site metastasis. Forms of disease range from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. Tumors are detected in the prostate as early as 10 weeks of age. The tumors have elevated levels of nuclear TRP53 and decreased androgen receptor expression.

Original:  J:65303 Greenberg NM, et al., Prostate cancer in a transgenic mouse. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3439-43
All:  333 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory