Ar^tm4(AR)Dmr
Targeted Allele Detail

Summary

• Symbol: Ar^tm4(AR)Dmr
• Name: androgen receptor; targeted mutation 4, Diane M Robins
• MGI ID: MGI:3612537
• Synonyms: AR113Q, Ar^tm1Apl
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm4(AR)Dmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104360
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Ar^tm4(AR)Dmr expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AR (367)

  Ar	(MGI:88064)

• Part of exon 1 was replaced by human AR exon 1 sequence with 113 CAG repeats. (J:104360)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 22 strains or lines available

References

• Original: J:104360 Yu Z, et al., Abnormalities of Germ Cell Maturation and Sertoli Cell Cytoskeleton in Androgen Receptor 113 CAG Knock-In Mice Reveal Toxic Effects of the Mutant Protein. Am J Pathol. 2006 Jan;168(1):195-204
• All: 24 reference(s)