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Ar Gene Detail
Summary
  • Symbol
    Ar
  • Name
    androgen receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88064
    NCBI Gene: 11835
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:97192375-97366821 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 42.82 cM
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2753 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88064
 protein coding gene ChrX:97192363-97366824 (+)
129S1/SvImJ ENSMUSG00200037631
 protein coding gene ChrX:78904330-79078804 (+)
A/J ENSMUSG00195031517
 protein coding gene ChrX:82647274-82828024 (+)
AKR/J ENSMUSG00220029130
 protein coding gene ChrX:77378160-77561077 (+)
BALB/cJ ENSMUSG00180020758
 protein coding gene ChrX:79365974-79539524 (+)
C3H/HeJ ENSMUSG00175018746
 protein coding gene ChrX:83019653-83200384 (+)
C57BL/6NJ ENSMUSG00215018915
 protein coding gene ChrX:79550903-79725357 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033258
 protein coding gene ChrX:92480947-92650344 (+)
CAST/EiJ ENSTCUG00005028213
 protein coding gene ChrX:80461100-80631529 (+)
CBA/J ENSMUSG00210032653
 protein coding gene ChrX:79767200-79947935 (+)
DBA/2J ENSMUSG00185039822
 protein coding gene ChrX:92243798-92418258 (+)
FVB/NJ ENSMUSG00205019421
 protein coding gene ChrX:78989887-79171521 (+)
JF1/MsJ ENSUMUG00000033520
 protein coding gene ChrX:112851092-113021779 (+)
LP/J ENSMUSG00230011222
 protein coding gene ChrX:98938069-99112525 (+)
NOD/ShiLtJ ENSMUSG00190017614
 protein coding gene ChrX:78949380-79123838 (+)
NZO/HlLtJ ENSMUSG00225044942
 protein coding gene ChrX:104069356-104243816 (+)
PWK/PhJ ENSLUMG00010037952
 protein coding gene ChrX:78141176-78311995 (+)
SPRET/EiJ ENSMSPG00010030348
 protein coding gene ChrX:82313244-82481881 (+)
WSB/EiJ ENSIUOG00005039964
 protein coding gene ChrX:79537383-79712122 (+)



Homology
more
  • Human Ortholog
    AR, androgen receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AR, androgen receptor
  • Synonyms
    AIS, AR8, DHTR, HPCX3, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
  • Links
    NCBI Gene ID: 367
    UniProt: P10275

  • Chr Location
    Xq12; chrX:67543353-67730619 (+)  GRCh38
  • MGI Vertebrate Homology
    Ar stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: AR
  • Gene Tree
    Ar
Human Diseases
more
  • Diseases
    3 with Ar mouse models; 14 with human AR associations

Human Disease Mouse Models
      
IDs
 View 8 models
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
IDs
 View 1 model
IDs
IDs
IDs
IDs
 View 4 models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    9 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    170 phenotypes from 16 alleles in 35 genetic backgrounds
    84 phenotypes from multigenic genotypes
    4 images
    398 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous mutant males are androgen-resistant and therefore have small, undescended testes, and lack epididymal structures, vas deferens, and male accessory glands. They resemble females physically and behaviorally, but lack female reproductive organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    228
  • GO References
    46
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1190
  • Tissues
    357
  • cDNA Data
    28
  • Literature Summary
    107
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046532 Ensembl Gene Model | MGI Sequence Detail 174447 C57BL/6J ±  kb
    transcript ENSMUST00000052837 Ensembl | MGI Sequence Detail 10048 Not Applicable  
    polypeptide ENSMUSP00000052648 Ensembl | MGI Sequence Detail 899 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 14
      cDNA 32
      Primer pair 17
      Other 5
      Antibodies 21

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1384, MGD-MRK-15046, MGI:2148007
    References
    more
    • Summaries
      All 724
      Developmental Gene Expression 107
      Diseases 12
      Gene Ontology 46
      Phenotypes 398
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:390482 Hunt KS, et al., Reduced Tumor Control in Males Can Result from Impaired CD4+ T-cell Help through the CD40L-CD40 Pathway. Cancer Immunol Res. 2026 Jul 2;14(7):1068-1079
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory