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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Vegfa

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vegfa
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0042056chemoattractant activityVEGFAIDAHumanPMID:17082651
Molecular FunctionGO:0042056chemoattractant activityVEGFAIDAHumanPMID:18059339
Molecular FunctionGO:0042056chemoattractant activityVEGFAIDAHumanPMID:18440775
Molecular FunctionGO:0042056chemoattractant activityVEGFAIDAHumanPMID:20497126
Molecular FunctionGO:0042056chemoattractant activityVEGFAIDAHumanPMID:21245381
Molecular FunctionGO:0042056chemoattractant activityVegfaIDAMouseMGI:MGI:5141569|PMID:21658587
Molecular FunctionGO:0042056chemoattractant activityVegfaIMPRatPMID:23226762|RGD:7207782
Molecular FunctionGO:0005125cytokine activityVEGFAIDAHumanPMID:18440775
Molecular FunctionGO:0001968fibronectin bindingVEGFAIDAHumanPMID:14570917
Molecular FunctionGO:0008083growth factor activityVEGFAIDAHumanPMID:20497126
Molecular FunctionGO:0008083growth factor activityVEGFAIDAHumanPMID:9202027
Molecular FunctionGO:0008083growth factor activityVegfaIDARatPMID:12181492|RGD:625593
Molecular FunctionGO:0008083growth factor activityVegfaIDARatPMID:16160062|RGD:2301956
Molecular FunctionGO:0008083growth factor activityvegfaaIMPZfishPMID:11578859|ZFIN:ZDB-PUB-011002-6
Molecular FunctionGO:0019838growth factor bindingVegfaIPIRGD:3444RatPMID:17881084|RGD:2292001
Molecular FunctionGO:0008201heparin bindingVEGFAIMPHumanPMID:14570917
Molecular FunctionGO:0008201heparin bindingVEGFAIDAHumanPMID:15001987
Molecular FunctionGO:0042802identical protein bindingVEGFAIPIUniProtKB:P15692HumanPMID:12207021
Molecular FunctionGO:0042802identical protein bindingVEGFAIPIUniProtKB:P15692HumanPMID:25132001
Molecular FunctionGO:0042802identical protein bindingVegfaIPIRGD:619991RatPMID:2320579|RGD:634362
Molecular FunctionGO:0005161platelet-derived growth factor receptor bindingVEGFAIPIUniProtKB:P09619HumanPMID:17470632
Molecular FunctionGO:0005161platelet-derived growth factor receptor bindingVEGFAIPIUniProtKB:P16234HumanPMID:17470632
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P17948HumanPMID:10543948
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:O14786HumanPMID:16763549
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P35968HumanPMID:16763549
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:O14786HumanPMID:17222790
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:B0L3A2HumanPMID:17446437
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P17948HumanPMID:20660291
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P35968HumanPMID:20660291
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:Q9H8L6HumanPMID:22020326
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P35968HumanPMID:23374253
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P35968HumanPMID:23583373
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P35613-2HumanPMID:25825981
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P35968HumanPMID:25825981
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P35968HumanPMID:31932617
Molecular FunctionGO:0005515protein bindingVEGFAIPIUniProtKB:P17948HumanPMID:9393862
Molecular FunctionGO:0005515protein bindingVegfaIPIUniProtKB:P97333MouseMGI:MGI:5698545|PMID:26503042
Molecular FunctionGO:0005515protein bindingvegfabIPIUniProtKB:Q5GIT4ZfishPMID:17698971|ZFIN:ZDB-PUB-070820-9
Molecular FunctionGO:0005515protein bindingvegfabIPIUniProtKB:Q8AXB3ZfishPMID:17698971|ZFIN:ZDB-PUB-070820-9
Molecular FunctionGO:0005515protein bindingvegfaaIPIUniProtKB:Q5GIT4ZfishPMID:17698971|ZFIN:ZDB-PUB-070820-9
Molecular FunctionGO:0005515protein bindingvegfaaIPIUniProtKB:Q8AXB3ZfishPMID:17698971|ZFIN:ZDB-PUB-070820-9
Molecular FunctionGO:0005515protein bindingvegfaaIPIZFIN:ZDB-GENE-040611-1ZfishPMID:15183302
Molecular FunctionGO:0048018receptor ligand activityVEGFAIPIUniProtKB:P35918HumanPMID:20660291
Molecular FunctionGO:0048018receptor ligand activityVEGFAIMPHumanPMID:23083510
Molecular FunctionGO:0043183vascular endothelial growth factor receptor 1 bindingVEGFAIPIUniProtKB:P17948HumanPMID:1312256
Molecular FunctionGO:0043184vascular endothelial growth factor receptor 2 bindingVEGFAIPIUniProtKB:P35968HumanPMID:10022831
Molecular FunctionGO:0043184vascular endothelial growth factor receptor 2 bindingVEGFAIPIUniProtKB:P35968HumanPMID:1417831
Molecular FunctionGO:0043184vascular endothelial growth factor receptor 2 bindingVEGFAIPIUniProtKB:P35968-2HumanPMID:20660291
Molecular FunctionGO:0043184vascular endothelial growth factor receptor 2 bindingVEGFAIPIUniProtKB:P35968HumanPMID:25825981
Molecular FunctionGO:0043184vascular endothelial growth factor receptor 2 bindingVegfaIMPRatPMID:18614764|RGD:2301848
Molecular FunctionGO:0005172vascular endothelial growth factor receptor bindingVEGFAIPIUniProtKB:P17948HumanPMID:10471394
Molecular FunctionGO:0005172vascular endothelial growth factor receptor bindingVEGFAIPIUniProtKB:P17948HumanPMID:11513746
Cellular ComponentGO:0005912adherens junctionVEGFAIDAHumanPMID:26598555
Cellular ComponentGO:0005604basement membraneVegfaIDARatPMID:11940521|RGD:628330
Cellular ComponentGO:0009986cell surfaceVEGFAIDAHumanPMID:17470632
Cellular ComponentGO:0005737cytoplasmVEGFAIDAHumanPMID:17082651
Cellular ComponentGO:0005737cytoplasmVegfaIDAMousePMID:12975317
Cellular ComponentGO:0005737cytoplasmVegfaIDAMousePMID:22886301
Cellular ComponentGO:0005576extracellular regionvegfaaIDAZfishPMID:17698971|ZFIN:ZDB-PUB-070820-9
Cellular ComponentGO:0005615extracellular spaceVEGFAIDAHumanPMID:16490744
Cellular ComponentGO:0005615extracellular spaceVEGFAIDAHumanPMID:9202027
Cellular ComponentGO:0005615extracellular spaceVegfaHDAMouseMGI:MGI:5640941|PMID:24006456
Cellular ComponentGO:0005615extracellular spaceVegfaIDAMousePMID:22009797
Cellular ComponentGO:0005615extracellular spaceVegfaIDAMousePMID:18559975
Cellular ComponentGO:0005615extracellular spaceVegfaIDAMousePMID:18753609
Cellular ComponentGO:0005615extracellular spaceVegfaIDAMousePMID:17475663
Cellular ComponentGO:0005615extracellular spaceVegfaIDAMousePMID:25184477
Cellular ComponentGO:0005615extracellular spaceVegfaIDAMousePMID:12053176
Cellular ComponentGO:0005615extracellular spaceVegfaIDAMousePMID:18772315
Cellular ComponentGO:0005615extracellular spaceVegfaIDARatPMID:15034080|RGD:1580562
Cellular ComponentGO:0005615extracellular spaceVegfaIDARatPMID:18758911|RGD:2301841
Cellular ComponentGO:0005634nucleusVegfaIDAMousePMID:22886301
Cellular ComponentGO:0030141secretory granuleVEGFAIDAHumanPMID:17082651
Cellular ComponentGO:1990150VEGF-A complexVEGFAIPIHumanPMID:12207021
Cellular ComponentGO:0031982vesicleVegfaIDARatPMID:18758911|RGD:2301841
Biological ProcessGO:0007202activation of phospholipase C activityvegfaaIDAZfishPMID:16537812
Biological ProcessGO:0032147activation of protein kinase activityVEGFAIDAHumanPMID:18059339
Biological ProcessGO:0032147activation of protein kinase activityVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0007568agingVegfaIEPRatPMID:18314447|RGD:8549775
Biological ProcessGO:0035479angioblast cell migration from lateral mesoderm to midlinevegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:11861480
Biological ProcessGO:0001525angiogenesisVEGFAIDAHumanPMID:11427521
Biological ProcessGO:0001525angiogenesisVEGFAIDAHumanPMID:21771332
Biological ProcessGO:0001525angiogenesisVegfaIMPMGI:MGI:1931048MousePMID:15073147
Biological ProcessGO:0001525angiogenesisVegfaIDAMousePMID:10617467
Biological ProcessGO:0001525angiogenesisVegfaIDAMousePMID:14998491
Biological ProcessGO:0001525angiogenesisVegfaIMPMGI:MGI:2386595MousePMID:14722611
Biological ProcessGO:0001525angiogenesisVegfaIMPMGI:MGI:1926815,MGI:MGI:1931048MousePMID:17625068
Biological ProcessGO:0001525angiogenesisVegfaIDAMousePMID:12975317
Biological ProcessGO:0001525angiogenesisVegfaIMPMGI:MGI:2386592MousePMID:14722611
Biological ProcessGO:0001525angiogenesisVegfaIMPMGI:MGI:2383985MousePMID:12890722
Biological ProcessGO:0001525angiogenesisVegfaIGIMGI:MGI:1202890MousePMID:16778080
Biological ProcessGO:0001525angiogenesisVegfaIMPRatPMID:16230500|RGD:1580552
Biological ProcessGO:0001525angiogenesisvegfaaIMPZfishPMID:11578859|ZFIN:ZDB-PUB-011002-6
Biological ProcessGO:0001525angiogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:16617120
Biological ProcessGO:0001525angiogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:23220656
Biological ProcessGO:0001525angiogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:18664627
Biological ProcessGO:0001525angiogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-051128-8ZfishPMID:20096681
Biological ProcessGO:0001525angiogenesisvegfaaIDAZfishPMID:11578859
Biological ProcessGO:0001525angiogenesisvegfaaIMPZFIN:ZDB-GENO-170209-1ZfishPMID:27557946
Biological ProcessGO:0001525angiogenesisvegfaaIGIZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-151026-1ZfishPMID:25001479
Biological ProcessGO:0001525angiogenesisvegfaaIGIZFIN:ZDB-GENE-050407-1ZfishPMID:28071661
Biological ProcessGO:0001525angiogenesisvegfaaIGIZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-051212-2,ZFIN:ZDB-MRPHLNO-051212-3ZfishPMID:16617120
Biological ProcessGO:0001525angiogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:16753140
Biological ProcessGO:0001525angiogenesisvegfaaIMPZfishPMID:25001479
Biological ProcessGO:0060978angiogenesis involved in coronary vascular morphogenesisVegfaIMPRatPMID:11397779|RGD:8655634
Biological ProcessGO:0006915apoptotic processVegfaIMPMGI:MGI:1931048MousePMID:15073147
Biological ProcessGO:0048844artery morphogenesisVegfaIMPMGI:MGI:1931047MousePMID:10229225
Biological ProcessGO:0048844artery morphogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-051212-1ZfishPMID:19815777
Biological ProcessGO:0001568blood vessel developmentVegfaIMPMousePMID:15927453
Biological ProcessGO:0001568blood vessel developmentVegfaIMPMGI:MGI:1931048,MGI:MGI:2387296MousePMID:16251428
Biological ProcessGO:0001568blood vessel developmentvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:26483474
Biological ProcessGO:0001568blood vessel developmentvegfaaIMPZFIN:ZDB-MRPHLNO-051128-8ZfishPMID:16968815
Biological ProcessGO:0001568blood vessel developmentvegfaaIMPZFIN:ZDB-MRPHLNO-051128-8ZfishPMID:25117453
Biological ProcessGO:0002043blood vessel endothelial cell proliferation involved in sprouting angiogenesisvegfaaIDAZfishPMID:16537812
Biological ProcessGO:0048514blood vessel morphogenesisVegfaIDAMousePMID:15919073
Biological ProcessGO:0048514blood vessel morphogenesisVegfaIGIMGI:MGI:98294MousePMID:15919073
Biological ProcessGO:0048514blood vessel morphogenesisVegfaIMPMousePMID:16027358
Biological ProcessGO:0001974blood vessel remodelingVegfaIMPRatPMID:16203926|RGD:1580556
Biological ProcessGO:0060346bone trabecula formationVegfaIMPMGI:MGI:1931048MousePMID:22886301
Biological ProcessGO:0061430bone trabecula morphogenesisVegfaIMPMGI:MGI:1931048MousePMID:22886301
Biological ProcessGO:0001569branching involved in blood vessel morphogenesisVEGFAIMPHumanPMID:23688497
Biological ProcessGO:0001569branching involved in blood vessel morphogenesisVEGFAIMPHumanPMID:23083510
Biological ProcessGO:0001569branching involved in blood vessel morphogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:19542015
Biological ProcessGO:0001569branching involved in blood vessel morphogenesisvegfaaIMPZfishPMID:11119306
Biological ProcessGO:0001569branching involved in blood vessel morphogenesisvegfaaIGIZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-110610-1ZfishPMID:19542015
Biological ProcessGO:0048593camera-type eye morphogenesisVegfaIMPMGI:MGI:1931048,MGI:MGI:2387296MousePMID:16251428
Biological ProcessGO:0055013cardiac muscle cell developmentVegfaIMPMGI:MGI:1931047MousePMID:10229225
Biological ProcessGO:0060948cardiac vascular smooth muscle cell developmentVegfaIMPMouseMGI:MGI:4461879|PMID:18093989
Biological ProcessGO:0003319cardioblast migration to the midline involved in heart rudiment formationvegfaaIMPZFIN:ZDB-GENO-190211-4ZfishPMID:28230770
Biological ProcessGO:0060326cell chemotaxisVegfaIMPRatPMID:23226762|RGD:7207782
Biological ProcessGO:0016477cell migrationVegfaIGIMGI:MGI:96683MousePMID:15601856
Biological ProcessGO:0016477cell migrationVegfaIGIMGI:MGI:95558MousePMID:15601856
Biological ProcessGO:0016477cell migrationVegfaIDAMousePMID:15601856
Biological ProcessGO:0002042cell migration involved in sprouting angiogenesisVEGFAIDAHumanPMID:18059339
Biological ProcessGO:0002042cell migration involved in sprouting angiogenesisVEGFAIDAHumanPMID:20660291
Biological ProcessGO:0008283cell population proliferationVegfaIMPMGI:MGI:2386595MousePMID:14722611
Biological ProcessGO:0008283cell population proliferationVegfaIMPMGI:MGI:2386592MousePMID:14722611
Biological ProcessGO:0098609cell-cell adhesionVegfaIGIMGI:MGI:87860MousePMID:24367707
Biological ProcessGO:0098609cell-cell adhesionVegfaIGIMGI:MGI:87859MousePMID:24367707
Biological ProcessGO:0071549cellular response to dexamethasone stimulusVegfaIEPRatPMID:10215998|RGD:7483563
Biological ProcessGO:0071391cellular response to estrogen stimulusVegfaIEPRatPMID:17272396|RGD:152177689
Biological ProcessGO:0044344cellular response to fibroblast growth factor stimulusVegfaIEPRatPMID:18617696|RGD:7421597
Biological ProcessGO:0071456cellular response to hypoxiaVEGFAIDAHumanPMID:10575000
Biological ProcessGO:0071260cellular response to mechanical stimulusVegfaIEPRatPMID:19012730|RGD:8662390
Biological ProcessGO:0035924cellular response to vascular endothelial growth factor stimulusVEGFAIDAHumanPMID:18440775
Biological ProcessGO:0035924cellular response to vascular endothelial growth factor stimulusVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0035924cellular response to vascular endothelial growth factor stimulusVegfaIGIUniProtKB:P97333MouseMGI:MGI:5562961|PMID:24401374
Biological ProcessGO:1904568cellular response to wortmanninVegfaIEPRatPMID:17272396|RGD:152177689
Biological ProcessGO:0071466cellular response to xenobiotic stimulusVegfaIEPRatPMID:22326847|RGD:7421605
Biological ProcessGO:0097533cellular stress response to acid chemicalVEGFAIDAHumanPMID:26299712
Biological ProcessGO:0022009central nervous system vasculogenesisvegfaaIMPZFIN:ZDB-GENO-190215-1ZfishPMID:29037991
Biological ProcessGO:0022009central nervous system vasculogenesisvegfaaIMPZFIN:ZDB-GENO-190207-17ZfishPMID:29037991
Biological ProcessGO:0071679commissural neuron axon guidanceVegfaIDAMouseMGI:MGI:5141569|PMID:21658587
Biological ProcessGO:0071679commissural neuron axon guidanceVegfaIMPMouseMGI:MGI:5141569|PMID:21658587
Biological ProcessGO:0060982coronary artery morphogenesisVegfaIMPMouseMGI:MGI:4461879|PMID:18093989
Biological ProcessGO:0003169coronary vein morphogenesisVegfaIMPMouseMGI:MGI:4461879|PMID:18093989
Biological ProcessGO:0071542dopaminergic neuron differentiationVegfaIGIMGI:MGI:106918MousePMID:17215402
Biological ProcessGO:0035907dorsal aorta developmentvegfaaIMPZFIN:ZDB-GENO-190207-17ZfishPMID:29037991
Biological ProcessGO:0003262endocardial progenitor cell migration to the midline involved in heart field formationvegfaaIGIZFIN:ZDB-MRPHLNO-051212-1,ZFIN:ZDB-MRPHLNO-080708-7,ZFIN:ZDB-MRPHLNO-110628-2,ZFIN:ZDB-MRPHLNO-110628-4ZfishPMID:21385766
Biological ProcessGO:0035767endothelial cell chemotaxisVEGFAIDAHumanPMID:18440775
Biological ProcessGO:0043542endothelial cell migrationVegfaIMPMousePMID:24403062
Biological ProcessGO:0001935endothelial cell proliferationVegfaIDAMousePMID:31698979
Biological ProcessGO:0030855epithelial cell differentiationVegfaIMPMGI:MGI:1931048,MGI:MGI:2387296MousePMID:16251428
Biological ProcessGO:0002070epithelial cell maturationVegfaIMPMGI:MGI:1931047MousePMID:12053176
Biological ProcessGO:0050673epithelial cell proliferationVegfaIMPMousePMID:15927453
Biological ProcessGO:0042462eye photoreceptor cell developmentVegfaIMPMGI:MGI:1931048,MGI:MGI:2387296MousePMID:16251428
Biological ProcessGO:0007565female pregnancyVegfaIEPRatPMID:16959835|RGD:8547953
Biological ProcessGO:0003007heart morphogenesisVegfaIMPMGI:MGI:1931047MousePMID:10229225
Biological ProcessGO:0030097hemopoiesisvegfaaIMPZfishPMID:11578859|ZFIN:ZDB-PUB-011002-6
Biological ProcessGO:0030097hemopoiesisvegfaaIDAZfishPMID:11578859
Biological ProcessGO:0048873homeostasis of number of cells within a tissueVegfaIMPMGI:MGI:1931048MousePMID:22886301
Biological ProcessGO:0001701in utero embryonic developmentVegfaIMPMGI:MGI:1931047MousePMID:10229225
Biological ProcessGO:0001822kidney developmentVegfaIMPMGI:MGI:1931047MousePMID:10229225
Biological ProcessGO:0007595lactationVegfaIMPMGI:MGI:1926815,MGI:MGI:1931048MousePMID:17625068
Biological ProcessGO:0048286lung alveolus developmentVegfaIMPRatPMID:16230500|RGD:1580552
Biological ProcessGO:0030324lung developmentVegfaIMPMGI:MGI:1931047MousePMID:12053176
Biological ProcessGO:0030324lung developmentVegfaIMPMousePMID:15927453
Biological ProcessGO:0060426lung vasculature developmentVegfaIMPMousePMID:11169844
Biological ProcessGO:0036303lymph vessel morphogenesisVegfaIMPMouseMGI:MGI:4461879|PMID:18093989
Biological ProcessGO:0001946lymphangiogenesisVegfaIDAMousePMID:20133819
Biological ProcessGO:0001946lymphangiogenesisVegfaIGIMGI:MGI:107163MousePMID:19233265
Biological ProcessGO:0001946lymphangiogenesisVegfaIGIMGI:MGI:102469MousePMID:19233265
Biological ProcessGO:0030225macrophage differentiationVEGFAIDAHumanPMID:21149635
Biological ProcessGO:0060749mammary gland alveolus developmentVegfaIMPMGI:MGI:1926815,MGI:MGI:1931048MousePMID:17625068
Biological ProcessGO:0007498mesoderm developmentVegfaIMPMGI:MGI:2383985MousePMID:12890722
Biological ProcessGO:0030224monocyte differentiationVEGFAIDAHumanPMID:21149635
Biological ProcessGO:0008045motor neuron axon guidancevegfaaIGIZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-050906-3ZfishPMID:16110501
Biological ProcessGO:0097475motor neuron migrationVegfaIMPMouseMGI:MGI:5698545|PMID:26503042
Biological ProcessGO:0048255mRNA stabilizationVegfaIDARatPMID:12881220|RGD:1580563
Biological ProcessGO:1903392negative regulation of adherens junction organizationVEGFAIDAHumanPMID:26598555
Biological ProcessGO:0043066negative regulation of apoptotic processVEGFAIMPHumanPMID:10066377
Biological ProcessGO:0043066negative regulation of apoptotic processVEGFAIMPHumanPMID:11461089
Biological ProcessGO:0043066negative regulation of apoptotic processVegfaIMPMGI:MGI:1931048MousePMID:15073147
Biological ProcessGO:1905604negative regulation of blood-brain barrier permeabilityVEGFAIMPHumanPMID:19148554
Biological ProcessGO:0045779negative regulation of bone resorptionVegfaIMPRatPMID:15312247|RGD:1580559
Biological ProcessGO:0022408negative regulation of cell-cell adhesionVegfaIGIMGI:MGI:87859MousePMID:24367707
Biological ProcessGO:0022408negative regulation of cell-cell adhesionVegfaIGIMGI:MGI:87860MousePMID:24367707
Biological ProcessGO:2000048negative regulation of cell-cell adhesion mediated by cadherinVEGFAIDAHumanPMID:26598555
Biological ProcessGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processVEGFAIDAHumanPMID:18386220
Biological ProcessGO:0010719negative regulation of epithelial to mesenchymal transitionVegfaIMPMouseMGI:MGI:5502250|PMID:23863481
Biological ProcessGO:1903141negative regulation of establishment of endothelial barrierVEGFAIDAHumanPMID:20048167
Biological ProcessGO:2001237negative regulation of extrinsic apoptotic signaling pathwayVegfaIDAMouseMGI:MGI:5287519|PMID:21828096
Biological ProcessGO:0045599negative regulation of fat cell differentiationVegfaIMPMGI:MGI:1931048MousePMID:22886301
Biological ProcessGO:0010629negative regulation of gene expressionVEGFAIMPUniProtKB:Q9UDY2HumanPMID:19148554
Biological ProcessGO:0010629negative regulation of gene expressionVEGFAIDAHumanPMID:28977001
Biological ProcessGO:0010629negative regulation of gene expressionVegfaIMPMousePMID:22886301
Biological ProcessGO:0043524negative regulation of neuron apoptotic processVegfaIDAMouseMGI:MGI:5287519|PMID:21828096
Biological ProcessGO:1901215negative regulation of neuron deathVegfaIMPRatPMID:17591953|RGD:7421609
Biological ProcessGO:0043069negative regulation of programmed cell deathVegfaIMPRatPMID:18614764|RGD:2301848
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIVEGFAIDAHumanPMID:18093989
Biological ProcessGO:0007399nervous system developmentVegfaIDARatPMID:12181492|RGD:625593
Biological ProcessGO:0007405neuroblast proliferationVegfaIGIMGI:MGI:106918MousePMID:17215402
Biological ProcessGO:0048666neuron developmentVegfaIMPMouseMGI:MGI:5287519|PMID:21828096
Biological ProcessGO:0003151outflow tract morphogenesisVegfaIMPMouseMGI:MGI:4461879|PMID:18093989
Biological ProcessGO:0001541ovarian follicle developmentVegfaIMPMousePMID:17050862
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationVegfaIDAMousePMID:18772315
Biological ProcessGO:0016310phosphorylationvegfaaIDAZfishPMID:17698971|ZFIN:ZDB-PUB-070820-9
Biological ProcessGO:0016310phosphorylationvegfabIDAZfishPMID:17698971|ZFIN:ZDB-PUB-070820-9
Biological ProcessGO:0050918positive chemotaxisVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0050918positive chemotaxisVegfaIDAMouseMGI:MGI:5141569|PMID:21658587
Biological ProcessGO:0045766positive regulation of angiogenesisVEGFAIMPHumanPMID:18275976
Biological ProcessGO:0045766positive regulation of angiogenesisVEGFAIDAHumanPMID:18440775
Biological ProcessGO:0045766positive regulation of angiogenesisVEGFAIDAHumanPMID:18577655
Biological ProcessGO:0045766positive regulation of angiogenesisVEGFAIDAHumanPMID:19033661
Biological ProcessGO:0045766positive regulation of angiogenesisVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0045766positive regulation of angiogenesisVegfaIDAMousePMID:20133819
Biological ProcessGO:0045766positive regulation of angiogenesisVegfaIDARatPMID:23562340|RGD:7421600
Biological ProcessGO:0045766positive regulation of angiogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:23132244
Biological ProcessGO:0048842positive regulation of axon extension involved in axon guidanceVegfaIDAMouseMGI:MGI:5141569|PMID:21658587
Biological ProcessGO:0048842positive regulation of axon extension involved in axon guidanceVegfaIMPMouseMGI:MGI:5141569|PMID:21658587
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationVEGFAIDAHumanPMID:18440775
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationVEGFAIMPHumanPMID:23688497
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationVEGFAIDAHumanPMID:9202027
Biological ProcessGO:1903589positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisVEGFAIMPHumanPMID:30106099
Biological ProcessGO:1903589positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisVEGFAIGIRNAcentral:URS00001230A0_9606HumanPMID:24844779
Biological ProcessGO:0090190positive regulation of branching involved in ureteric bud morphogenesisVegfaIDAMouseMGI:MGI:3611700|PMID:16291795
Biological ProcessGO:0045785positive regulation of cell adhesionVEGFAIDAHumanPMID:19674970
Biological ProcessGO:0030335positive regulation of cell migrationVEGFAIDAHumanPMID:17470632
Biological ProcessGO:0030335positive regulation of cell migrationVEGFAIDAHumanPMID:7929439
Biological ProcessGO:0090050positive regulation of cell migration involved in sprouting angiogenesisVEGFAIDAHumanPMID:20551324
Biological ProcessGO:0090050positive regulation of cell migration involved in sprouting angiogenesisVEGFAIMPHumanPMID:23083510
Biological ProcessGO:0090050positive regulation of cell migration involved in sprouting angiogenesisVEGFAIGIRNAcentral:URS00001230A0_9606HumanPMID:24844779
Biological ProcessGO:0090050positive regulation of cell migration involved in sprouting angiogenesisVEGFAIMPHumanPMID:24865854
Biological ProcessGO:0008284positive regulation of cell population proliferationVEGFAIMPHumanPMID:26268439
Biological ProcessGO:0008284positive regulation of cell population proliferationVEGFAIDAHumanPMID:7929439
Biological ProcessGO:0008284positive regulation of cell population proliferationVegfaIDAMousePMID:17475663
Biological ProcessGO:0008284positive regulation of cell population proliferationVegfaIMPRatPMID:18614764|RGD:2301848
Biological ProcessGO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayVEGFAIDAHumanPMID:17470632
Biological ProcessGO:0120162positive regulation of cold-induced thermogenesisVegfaIMPMouseMGI:MGI:6100994|PMID:26683794
Biological ProcessGO:0032793positive regulation of CREB transcription factor activityVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayVEGFAIDAHumanPMID:18440775
Biological ProcessGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayVEGFAIDAHumanPMID:21245381
Biological ProcessGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayVEGFAIDAHumanPMID:31915155
Biological ProcessGO:0010595positive regulation of endothelial cell migrationVEGFAIDAHumanPMID:10022831
Biological ProcessGO:0010595positive regulation of endothelial cell migrationVEGFAIDAHumanPMID:19033661
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationVEGFAIDAHumanPMID:12714610
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationVEGFAIDAHumanPMID:10022831
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationVEGFAIDAHumanPMID:16489009
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationVEGFAIDAHumanPMID:18386220
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationVEGFAIDAHumanPMID:18577655
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationVEGFAIDAHumanPMID:31915155
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationVEGFAIDAHumanPMID:9202027
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationVegfaIMPMousePMID:15927453
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeVegfaIDAMouseMGI:MGI:5287519|PMID:21828096
Biological ProcessGO:0051894positive regulation of focal adhesion assemblyVEGFAIDAHumanPMID:16489009
Biological ProcessGO:0010628positive regulation of gene expressionVEGFAIDAHumanPMID:18386220
Biological ProcessGO:1901727positive regulation of histone deacetylase activityVEGFAIDAHumanPMID:20497126
Biological ProcessGO:1901492positive regulation of lymphangiogenesisVegfaIDAMousePMID:20133819
Biological ProcessGO:0043406positive regulation of MAP kinase activityVEGFAIDAHumanPMID:18440775
Biological ProcessGO:0002052positive regulation of neuroblast proliferationVegfaIGIMGI:MGI:106918MousePMID:17215402
Biological ProcessGO:0045669positive regulation of osteoblast differentiationVegfaIMPMGI:MGI:1931048MousePMID:22886301
Biological ProcessGO:1900745positive regulation of p38MAPK cascadeVEGFAIDAHumanPMID:18386220
Biological ProcessGO:0033138positive regulation of peptidyl-serine phosphorylationVEGFAIDAHumanPMID:18440775
Biological ProcessGO:0033138positive regulation of peptidyl-serine phosphorylationVEGFAIDAHumanPMID:20497126
Biological ProcessGO:1900086positive regulation of peptidyl-tyrosine autophosphorylationVEGFAIDAHumanPMID:20660291
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationVEGFAIDAHumanPMID:10022831
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationVEGFAIDAHumanPMID:16489009
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationVEGFAIDAHumanPMID:20048167
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationVEGFAIDAHumanPMID:21245381
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationVEGFAIDAHumanPMID:26598555
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationVegfaIDAMousePMID:18772315
Biological ProcessGO:0050927positive regulation of positive chemotaxisVEGFAIDAHumanPMID:12744932
Biological ProcessGO:0050927positive regulation of positive chemotaxisVEGFAIDAHumanPMID:7929439
Biological ProcessGO:0031954positive regulation of protein autophosphorylationVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0051897positive regulation of protein kinase B signalingVegfaIDAMouseMGI:MGI:5287519|PMID:21828096
Biological ProcessGO:0090037positive regulation of protein kinase C signalingVEGFAIDAHumanPMID:18059339
Biological ProcessGO:1903572positive regulation of protein kinase D signalingVEGFAIDAHumanPMID:20497126
Biological ProcessGO:0001934positive regulation of protein phosphorylationVEGFAIDAHumanPMID:18386220
Biological ProcessGO:0001934positive regulation of protein phosphorylationVEGFAIDAHumanPMID:19033661
Biological ProcessGO:0031334positive regulation of protein-containing complex assemblyVEGFAIDAHumanPMID:16489009
Biological ProcessGO:0031334positive regulation of protein-containing complex assemblyVEGFAIDAHumanPMID:19033661
Biological ProcessGO:0002092positive regulation of receptor internalizationVEGFAIDAHumanPMID:20660291
Biological ProcessGO:1902336positive regulation of retinal ganglion cell axon guidanceVegfaIMPMouseMGI:MGI:5141569|PMID:21658587
Biological ProcessGO:0009967positive regulation of signal transductionVegfaIDARatPMID:12483534|RGD:634256
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationVegfaIMPRatPMID:14693680|RGD:1580560
Biological ProcessGO:1903672positive regulation of sprouting angiogenesisVEGFAIGIRNAcentral:URS000007F792_9606HumanPMID:25251394
Biological ProcessGO:1903672positive regulation of sprouting angiogenesisVEGFAIDAHumanPMID:26299712
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIVEGFAIDAHumanPMID:18059339
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIVEGFAIMPHumanPMID:18093989
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIVegfaIDARatPMID:12881220|RGD:1580563
Biological ProcessGO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaVEGFAIMPHumanPMID:19652095
Biological ProcessGO:1901165positive regulation of trophoblast cell migrationVEGFAIMPHumanPMID:23083510
Biological ProcessGO:1900748positive regulation of vascular endothelial growth factor signaling pathwayVEGFAIDAHumanPMID:23688497
Biological ProcessGO:0043117positive regulation of vascular permeabilityVEGFAIDAHumanPMID:26598555
Biological ProcessGO:0043117positive regulation of vascular permeabilityVegfaIDAMousePMID:10617467
Biological ProcessGO:0043117positive regulation of vascular permeabilityVegfaIDAMousePMID:24403062
Biological ProcessGO:0043117positive regulation of vascular permeabilityVegfaIMPRatPMID:16793871|RGD:1580547
Biological ProcessGO:0031077post-embryonic camera-type eye developmentVegfaIMPMGI:MGI:1931047MousePMID:10229225
Biological ProcessGO:0060319primitive erythrocyte differentiationVegfaIMPMGI:MGI:2383985MousePMID:14729577
Biological ProcessGO:0048793pronephros developmentvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:16753140
Biological ProcessGO:0043491protein kinase B signalingvegfaaIDAZfishPMID:16537812
Biological ProcessGO:0035477regulation of angioblast cell migration involved in selective angioblast sproutingvegfaaIMPZFIN:ZDB-MRPHLNO-051212-1ZfishPMID:19815777
Biological ProcessGO:0008360regulation of cell shapeVEGFAIDAHumanPMID:10527820
Biological ProcessGO:0008360regulation of cell shapeVEGFAIDAHumanPMID:7929439
Biological ProcessGO:0045601regulation of endothelial cell differentiationVegfaIDAMousePMID:18772315
Biological ProcessGO:0040008regulation of growthVegfaIMPMGI:MGI:1931047MousePMID:10229225
Biological ProcessGO:0008016regulation of heart contractionvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:15998812
Biological ProcessGO:1901532regulation of hematopoietic progenitor cell differentiationVegfaIDAMousePMID:18772315
Biological ProcessGO:0010749regulation of nitric oxide mediated signal transductionVEGFAIDAHumanPMID:16150726
Biological ProcessGO:0090259regulation of retinal ganglion cell axon guidanceVegfaIDAMouseMGI:MGI:5141569|PMID:21658587
Biological ProcessGO:0090259regulation of retinal ganglion cell axon guidanceVegfaIMPMouseMGI:MGI:5141569|PMID:21658587
Biological ProcessGO:1901342regulation of vasculature developmentvegfaaIGIZFIN:ZDB-MRPHLNO-050119-3,ZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:22884368
Biological ProcessGO:0009409response to coldVegfaIEPRatPMID:10342292|RGD:2314329
Biological ProcessGO:0071548response to dexamethasoneVegfaIEPRatPMID:16959835|RGD:8547953
Biological ProcessGO:0032355response to estradiolVegfaIEPRatPMID:8344219|RGD:7483564
Biological ProcessGO:0051593response to folic acidVegfaIEPRatPMID:17482424|RGD:7421601
Biological ProcessGO:0009749response to glucosevegfaaIDAZfishPMID:26276677
Biological ProcessGO:0001666response to hypoxiaVEGFAIDAHumanPMID:16490744
Biological ProcessGO:0001666response to hypoxiaVegfaIDARatPMID:12881220|RGD:1580563
Biological ProcessGO:0070482response to oxygen levelsVegfaIEPRatPMID:15885787|RGD:8549762
Biological ProcessGO:0032570response to progesteroneVegfaIEPRatPMID:8344219|RGD:7483564
Biological ProcessGO:0033189response to vitamin AVegfaIEPRatPMID:23106861|RGD:7483561
Biological ProcessGO:0002040sprouting angiogenesisVegfaIDAMouseMGI:MGI:5562961|PMID:24401374
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIMPZFIN:ZDB-GENO-190207-16ZfishPMID:29037991
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIMPZFIN:ZDB-GENO-190207-17ZfishPMID:29037991
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIMPZFIN:ZDB-GENO-190215-1ZfishPMID:29037991
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIGIZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:30953479
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIGIZFIN:ZDB-GENO-200824-1ZfishPMID:30953479
Biological ProcessGO:0002040sprouting angiogenesisvegfabIGIZFIN:ZDB-MRPHLNO-080516-7,ZFIN:ZDB-MRPHLNO-120719-2ZfishPMID:22516065
Biological ProcessGO:0002040sprouting angiogenesisvegfabIGIZFIN:ZDB-MRPHLNO-080516-7,ZFIN:ZDB-MRPHLNO-120719-4ZfishPMID:22516065
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIGIZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2ZfishPMID:22903062
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIGIZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-110610-1ZfishPMID:19542015
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:22903062
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:11861480
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIGIZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-060802-1ZfishPMID:16537812
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIGIZFIN:ZDB-MRPHLNO-060802-1ZfishPMID:16537812
Biological ProcessGO:0002040sprouting angiogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-051212-1ZfishPMID:19815777
Biological ProcessGO:0043129surfactant homeostasisVegfaIMPMGI:MGI:1931047MousePMID:12053176
Biological ProcessGO:0042088T-helper 1 type immune responseVegfaIDARatPMID:15034080|RGD:1580562
Biological ProcessGO:0030878thyroid gland developmentvegfaaIMPZFIN:ZDB-MRPHLNO-051128-8ZfishPMID:16968815
Biological ProcessGO:0035148tube formationVEGFAIDAHumanPMID:19033661
Biological ProcessGO:0048010vascular endothelial growth factor receptor signaling pathwayVEGFAIDAHumanPMID:1312256
Biological ProcessGO:0048010vascular endothelial growth factor receptor signaling pathwayVEGFAIDAHumanPMID:21245381
Biological ProcessGO:0048010vascular endothelial growth factor receptor signaling pathwayVEGFAIDAHumanPMID:7929439
Biological ProcessGO:0048010vascular endothelial growth factor receptor signaling pathwayVegfaIMPRatPMID:18614764|RGD:2301848
Biological ProcessGO:0048010vascular endothelial growth factor receptor signaling pathwayvegfaaIGIZFIN:ZDB-GENO-980202-1526ZfishPMID:12110173
Biological ProcessGO:0036324vascular endothelial growth factor receptor-2 signaling pathwayVEGFAIMPHumanPMID:23688497
Biological ProcessGO:0038084vascular endothelial growth factor signaling pathwayVEGFAIMPHumanPMID:23083510
Biological ProcessGO:0038084vascular endothelial growth factor signaling pathwayVegfaIDAMouseMGI:MGI:5287519|PMID:21828096
Biological ProcessGO:0061042vascular wound healingVEGFAIMPHumanPMID:23688497
Biological ProcessGO:0001944vasculature developmentVegfaIMPMGI:MGI:1931047MousePMID:10229225
Biological ProcessGO:0001944vasculature developmentvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:12142468
Biological ProcessGO:0001944vasculature developmentvegfaaIGIZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-050906-3ZfishPMID:12142468
Biological ProcessGO:0001944vasculature developmentvegfaaIMPZFIN:ZDB-MRPHLNO-051128-8ZfishPMID:23212515
Biological ProcessGO:0001944vasculature developmentvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:22884368
Biological ProcessGO:0001570vasculogenesisvegfaaIMPZfishPMID:11578859|ZFIN:ZDB-PUB-011002-6
Biological ProcessGO:0001570vasculogenesisvegfaaIMPZfishPMID:12110173
Biological ProcessGO:0001570vasculogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:16110501
Biological ProcessGO:0001570vasculogenesisvegfaaIMPZFIN:ZDB-MRPHLNO-050513-12ZfishPMID:15998812
Biological ProcessGO:0001570vasculogenesisvegfaaIDAZfishPMID:11578859
Biological ProcessGO:0042311vasodilationVegfaIDAMousePMID:31698979
Biological ProcessGO:0038190VEGF-activated neuropilin signaling pathwayVegfaIMPMouseMGI:MGI:5141569|PMID:21658587
Biological ProcessGO:0060841venous blood vessel developmentvegfaaIMPZFIN:ZDB-GENO-190207-16ZfishPMID:29037991
Biological ProcessGO:0042060wound healingVegfaIEPRatPMID:24012216|RGD:8547981

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory