Vegfa
Gene Detail

Symbol

Name
ID

Vegfa
vascular endothelial growth factor A
MGI:103178

Synonyms

Vegf, VEGF120, VEGF164, VEGF188, VEGF-A, VPF

Feature Type

protein coding gene

Genetic Map

Chromosome 17
22.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:46016993-46032369 bp, - strand From VEGA annotation of GRCm38   15377 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vascular endothelial growth factor A
Gene Tree: Vegfa

Human
homologs

Human Homolog		VEGFA, vascular endothelial growth factor A
NCBI Gene ID		7422
neXtProt AC		NX_P15692
Human Synonyms		MVCD1, VEGF, VPF
Human Chr (Location)		6p12; chr6:43770209-43786487 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human VEGFA

Mutations,
alleles, and
phenotypes

All mutations/alleles(17) : Gene trapped(1) Targeted(15) Transgenic(1)
Incidental mutations (data from APF )
 

Hetero- or homozygous null mutants show embryonic lethality with impaired angiogenesis and blood-island formation. Mutants selectively expressing isoform 120 or 188 exhibit vascular outgrowth/patterning defects or impaired arterial development, respectively.

 
Human Diseases Modeled in Mice Using Vegfa (3)    Mutations Annotated to Human Diseases (3)   

Interactions

Vegfa interacts with 320 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (199 annotations)

Process	activation of protein kinase activity, angiogenesis, ...
Component	basement membrane, cell surface, ...
Function	chemoattractant activity, cytokine activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (330 records)

Data Summary: Results (483)    Tissues (275)    Images (176)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	27
RNA in situ	146
In situ reporter (knock in)	116
Northern blot	25
Western blot	6
RT-PCR	163

cDNA source data(85)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(123) Genomic(3) cDNA(89) Primer pair(28) Other(3)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000016285 (Evidence)
Ensembl Gene Model	ENSMUSG00000023951 (Evidence)
Entrez Gene	22339 (Evidence)
UniGene	282184
DFCI	TC1577211, TC1772920, TC1632790, TC1716126, TC1712145, TC1710020, TC1636125
DoTS	DT.99848866, DT.97344253, DT.101734699, DT.94368491, DT.101383927, DT.50316396, DT.103567033, DT.110553770, DT.110553751
Consensus CDS Project	CCDS28816.2, CCDS28817.2, CCDS28818.2, CCDS70817.1
International Mouse Knockout Project Status	Vegfa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016285	VEGA Gene Model | MGI Sequence Detail	15377	C57BL/6J
transcript	OTTMUST00000039104	VEGA | MGI Sequence Detail	1973	Not Applicable
polypeptide	OTTMUSP00000017464	VEGA | MGI Sequence Detail	392	Not Applicable

All sequences(114) RefSeq(18) UniProt(17)

Polymorphisms

PCR(1) : SNPs within 2kb(228 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR023581	Platelet-derived growth factor, conserved site
InterPro	IPR000072	Platelet-derived growth factor (PDGF)
Protein Ontology	PR:000017284	vascular endothelial growth factor A

References

(Earliest) J:27451 Breier G, et al., Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 1992 Feb;114(2):521-32
(Latest) J:215459 Hellbach N, et al., Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90
All references(589)
Disease annotation references (3)

Other
accession IDs

MGD-MRK-24046