Vegfa
Gene Detail

Symbol Name ID

Vegfa vascular endothelial growth factor A MGI:103178

Synonyms

Vegf, VEGF120, VEGF164, VEGF188, VEGF-A, VPF

Feature Type

protein coding gene

Genetic Map

Chromosome 17

22.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:46016993-46032369 bp, - strand From VEGA annotation of GRCm38   15377 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vascular endothelial growth factor A
Gene Tree: Vegfa

Human homologs

Human Homolog		VEGFA, vascular endothelial growth factor A
NCBI Gene ID		7422
neXtProt AC		NX_P15692
Human Synonyms		MVCD1, VEGF, VPF
Human Chr (Location)		6p12; chr6:43770209-43786487 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human VEGFA

Alleles and phenotypes

All alleles(13) : Gene trapped(1) Targeted(12)
Incidental mutations (data from APF )
 

Hetero- or homozygous null mutants show embryonic lethality with impaired angiogenesis and blood-island formation. Mutants selectively expressing isoform 120 or 188 exhibit vascular outgrowth/patterning defects or impaired arterial development, respectively.

 
Human Diseases Modeled Using Mouse Vegfa (3)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (192 annotations)

Process	activation of protein kinase activity, angiogenesis, ...
Component	basement membrane, cell surface, ...
Function	chemoattractant activity, cytokine activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (319 records)

Data Summary: Results (483)    Tissues (272)    Images (176)
Theiler Stages: 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	146
In situ reporter (knock in)	116
Northern blot	25
Western blot	6
RT-PCR	163

cDNA source data(85)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(123) Genomic(3) cDNA(89) Primer pair(28) Other(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000016285 (Evidence)
Ensembl Gene Model	ENSMUSG00000023951 (Evidence)
Entrez Gene	22339 (Evidence)
UniGene	282184
DFCI	TC1577211, TC1632790, TC1636125, TC1710020, TC1712145, TC1716126, TC1772920
DoTS	DT.101383927, DT.101734699, DT.103567033, DT.110553751, DT.110553770, DT.50316396, DT.94368491, DT.97344253, DT.99848866
Consensus CDS Project	CCDS28816.2, CCDS28817.2, CCDS28818.2, CCDS70817.1
International Mouse Knockout Project Status	Vegfa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016285	VEGA Gene Model | MGI Sequence Detail	15377	C57BL/6J
transcript	OTTMUST00000039104	VEGA | MGI Sequence Detail	1973	Not Applicable
polypeptide	OTTMUSP00000017464	VEGA | MGI Sequence Detail	392	Not Applicable

All sequences(106) RefSeq(18) UniProt(9)

Polymorphisms

PCR(1) : SNPs within 2kb(228 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR023581	Platelet-derived growth factor, conserved site
InterPro	IPR000072	Platelet-derived growth factor (PDGF)
Protein Ontology	PR:000017284	vascular endothelial growth factor A

References

(Earliest) J:27451 Breier G, et al., Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 1992 Feb;114(2):521-32
(Latest) J:210628 Kawano N, et al., Absence of CD9 reduces endometrial VEGF secretion and impairs uterine repair after parturition. Sci Rep. 2014;4:4701
All references(564)

Other accession IDs

MGD-MRK-24046