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Vegfa
Gene Detail
Symbol

Name
ID
Vegfa
vascular endothelial growth factor A
MGI:103178
Synonyms
Vegf, VEGF120, VEGF164, VEGF188, VEGF-A, VPF
Feature Type
protein coding gene
Genetic Map
Chromosome 17
22.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:46016993-46032369 bp, - strand
From VEGA annotation of GRCm38

  15377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vascular endothelial growth factor A
Gene Tree: Vegfa

Human
homologs
Human Homolog   VEGFA, vascular endothelial growth factor A
NCBI Gene ID 7422
neXtProt AC  NX_P15692
Human Synonyms  MVCD1, VEGF, VPF
Human Chr (Location)  6p12; chr6:43770209-43786487 (+)  GRCh38.p2
Disease Associations  (2) Diseases Associated with Human VEGFA
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(1) Targeted(15) Transgenic(1)
Incidental mutations (data from APF )
 
Hetero- or homozygous null mutants show embryonic lethality with impaired angiogenesis and blood-island formation. Mutants selectively expressing isoform 120 or 188 exhibit vascular outgrowth/patterning defects or impaired arterial development, respectively.
 
Human Diseases Modeled in Mice Using Vegfa (3)    Mutations Annotated to Human Diseases (3)   
Interactions
Vegfa interacts with 319 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (199 annotations)
Process activation of protein kinase activity, angiogenesis, ...
Component basement membrane, cell surface, ...
Function chemoattractant activity, cytokine activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (336 records)
Data Summary: Results (483)    Tissues (275)    Images (176)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 27
RNA in situ 146
In situ reporter (knock in) 116
Northern blot 25
Western blot 6
RT-PCR 163
cDNA source data(85)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) Genomic(3) cDNA(89) Primer pair(28) Other(3)
Microarray probesets(6)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016285 VEGA Gene Model | MGI Sequence Detail 15377 C57BL/6J ±  kb
transcript OTTMUST00000039104 VEGA | MGI Sequence Detail 1973 Not Applicable 
polypeptide OTTMUSP00000017464 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(106) RefSeq(18) UniProt(9)
Polymorphisms
PCR(1) : SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023581 Platelet-derived growth factor, conserved site
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000017284 vascular endothelial growth factor A
References
(Earliest) J:27451 Breier G, et al., Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 1992 Feb;114(2):521-32
(Latest) J:218159 Eshkar-Oren I, et al., Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism. Development. 2015 Feb 15;142(4):672-80
All references(602)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-24046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/28/2015
MGI 5.21
The Jackson Laboratory