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Vegfa Gene Detail
Summary
  • Symbol
    Vegfa
  • Name
    vascular endothelial growth factor A
  • Synonyms
    Vegf, VEGF120, VEGF164, VEGF188, VEGF-A, VPF
  • Feature Type
    protein coding gene
  • IDs
    MGI:103178
    NCBI Gene: 22339
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr17:46016993-46032369 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      15377 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.79 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    VEGFA, vascular endothelial growth factor A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    VEGFA, vascular endothelial growth factor A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MVCD1, VEGF, VPF
  • Links
    NCBI Gene ID: 7422
    neXtProt AC: NX_P15692
    UniProt: P15692

  • Chr Location
    6p21.1; chr6:43770209-43786487 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    4 with Vegfa mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    262 phenotypes from 14 alleles in 22 genetic backgrounds
    22 phenotypes from multigenic genotypes
    207 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Hetero- or homozygous null mutants show embryonic lethality with impaired angiogenesis and blood-island formation. Mutants selectively expressing isoform 120 or 188 exhibit vascular outgrowth/patterning defects or impaired arterial development, respectively.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    252
  • GO References
    59
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    578
  • Tissues
    331
  • cDNA Data
    87
  • Literature Summary
    408
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016285 VEGA Gene Model | MGI Sequence Detail 15377 C57BL/6J ±  kb
    transcript OTTMUST00000039104 VEGA | MGI Sequence Detail 1973 Not Applicable  
    polypeptide OTTMUSP00000017464 VEGA | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      207 from dbSNP Build 142
    • PCR
      1
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000017284 vascular endothelial growth factor A
      (term hierarchy)
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR000072 PDGF/VEGF domain
      IPR023581 Platelet-derived growth factor, conserved site
      IPR027928 Vascular endothelial growth factor, heparin-binding domain
      IPR036841 Vascular endothelial growth factor, heparin-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 130
      Genomic 3
      cDNA 92
      Primer pair 32
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-24046
    References
    more
    • Summaries
      All 914
      Developmental Gene Expression 408
      Diseases 4
      Gene Ontology 59
      Phenotypes 207
    • Earliest
      J:27451 Breier G, et al., Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 1992 Feb;114(2):521-32
    • Latest
      J:264149 Goto S, et al., Neural retina-specific Aldh1a1 controls dorsal choroidal vascular development via Sox9 expression in retinal pigment epithelial cells. Elife. 2018 Apr 3;7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/16/2018
    MGI 6.12     		The Jackson Laboratory