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Vegfa
Gene Detail
 Symbol
Name
ID
Vegfa
vascular endothelial growth factor A
MGI:103178
Synonyms Vegf, VEGF120, VEGF164, VEGF188, VEGF-A, VPF
Feature Type protein coding gene
Genetic Map
Chromosome 17
22.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:46016993-46032369 bp, - strand
From VEGA annotation of GRCm38

  15377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vascular endothelial growth factor A
Gene Tree: Vegfa

Human
homologs
Human Homolog VEGFA, vascular endothelial growth factor A
NCBI Gene ID 7422
neXtProt AC  NX_P15692
Human Synonyms  MVCD1, VEGF, VPF
Human Chr (Location)  6p12; chr6:43770209-43786487 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human VEGFA
Alleles
and
phenotypes
All alleles(13) : Gene trapped(1) Targeted(12)
Incidental mutations (data from APF )
 
Hetero- or homozygous null mutants show embryonic lethality with impaired angiogenesis and blood-island formation. Mutants selectively expressing isoform 120 or 188 exhibit vascular outgrowth/patterning defects or impaired arterial development, respectively.
 
Human Diseases Modeled Using Mouse Vegfa (3)    Alleles Annotated to Human Diseases(3)   
Gene Ontology
(GO)
classifications
All GO classifications: (192 annotations)
Process activation of protein kinase activity, angiogenesis, ...
Component basement membrane, cell surface, ...
Function chemoattractant activity, cytokine activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (319 records)
Data Summary: Results (483)    Tissues (272)    Images (176)
Theiler Stages: 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 27
RNA in situ 146
In situ reporter (knock in) 116
Northern blot 25
Western blot 6
RT-PCR 163
cDNA source data(85)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(123) Genomic(3) cDNA(89) Primer pair(28) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016285 (Evidence)
Ensembl Gene ModelENSMUSG00000023951 (Evidence)
Entrez Gene22339 (Evidence)
UniGene282184
DFCITC1577211, TC1632790, TC1636125, TC1710020, TC1712145, TC1716126, TC1772920
DoTSDT.101383927, DT.101734699, DT.103567033, DT.110553751, DT.110553770, DT.50316396, DT.94368491, DT.97344253, DT.99848866
Consensus CDS ProjectCCDS28816.2, CCDS28817.2, CCDS28818.2, CCDS70817.1
International Mouse Knockout Project StatusVegfa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016285 VEGA Gene Model | MGI Sequence Detail 15377 C57BL/6J ±  kb
transcript OTTMUST00000039104 VEGA | MGI Sequence Detail 1973 Not Applicable 
polypeptide OTTMUSP00000017464 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(106) RefSeq(18) UniProt(9)
Polymorphisms PCR(1) : SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023581 Platelet-derived growth factor, conserved site
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000017284 vascular endothelial growth factor A
References (Earliest) J:27451 Breier G, et al., Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 1992 Feb;114(2):521-32
(Latest) J:210628 Kawano N, et al., Absence of CD9 reduces endometrial VEGF secretion and impairs uterine repair after parturition. Sci Rep. 2014;4:4701
All references(564)
Other
accession IDs
MGD-MRK-24046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory