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Vegfa
Gene Detail
Symbol

Name
ID
Vegfa
vascular endothelial growth factor A
MGI:103178
Synonyms
Vegf, VEGF120, VEGF164, VEGF188, VEGF-A, VPF
Feature Type
protein coding gene
Genetic Map
Chromosome 17
22.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:46016993-46032369 bp, - strand
From VEGA annotation of GRCm38

  15377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: VEGFA
Protein SuperFamily: vascular endothelial growth factor A
Gene Tree: Vegfa

Human
homologs
VEGFA, vascular endothelial growth factor A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7422
neXtProt AC: NX_P15692

Human Synonyms: MVCD1, VEGF, VPF

Human Chr (Location): 6p12; chr6:43770209-43786487 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human VEGFA

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(1) Targeted(15) Transgenic(1)
Incidental mutations (data from APF )
 
Hetero- or homozygous null mutants show embryonic lethality with impaired angiogenesis and blood-island formation. Mutants selectively expressing isoform 120 or 188 exhibit vascular outgrowth/patterning defects or impaired arterial development, respectively.
 
Human Diseases Modeled in Mice Using Vegfa (3)    Mutations Annotated to Human Diseases (3)   
Interactions
Vegfa interacts with 319 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (200 annotations)
Process activation of protein kinase activity, angiogenesis, ...
Component basement membrane, cell surface, ...
Function chemoattractant activity, cytokine activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (340 records)
Data Summary: Results (483)    Tissues (275)    Images (176)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 27
RNA in situ 146
In situ reporter (knock in) 116
Northern blot 25
Western blot 6
RT-PCR 163
cDNA source data(85)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA VEGFA ; Xenbase vegfa ; ZFIN vegfaa, vegfab    NEW 
Molecular
reagents
All nucleic(123) Genomic(3) cDNA(89) Primer pair(28) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016285 (Evidence)
Ensembl Gene Model ENSMUSG00000023951 (Evidence)
Entrez Gene 22339 (Evidence)
UniGene 282184
DFCI TC1636125, TC1632790, TC1577211, TC1716126, TC1712145, TC1710020, TC1772920
DoTS DT.50316396, DT.110553770, DT.110553751, DT.103567033, DT.101734699, DT.101383927, DT.94368491, DT.97344253, DT.99848866
Consensus CDS Project CCDS28816.2, CCDS28817.2, CCDS28818.2, CCDS70817.1
International Mouse Phenotyping Consortium Status Vegfa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016285 VEGA Gene Model | MGI Sequence Detail 15377 C57BL/6J ±  kb
transcript OTTMUST00000039104 VEGA | MGI Sequence Detail 1973 Not Applicable 
polypeptide OTTMUSP00000017464 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(18) UniProt(10)
Polymorphisms
PCR(1) : SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023581 Platelet-derived growth factor, conserved site
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000017284 vascular endothelial growth factor A
References
(Earliest) J:27451 Breier G, et al., Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 1992 Feb;114(2):521-32
(Latest) J:220733 Kirby ED, et al., Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4128-33
All references(607)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-24046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory