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Vegfa Gene Detail
Summary
  • Symbol
    Vegfa
  • Name
    vascular endothelial growth factor A
  • Synonyms
    Vegf, VEGF120, VEGF164, VEGF188, VEGF-A, VPF
  • Feature Type
    protein coding gene
  • IDs
    MGI:103178
    NCBI Gene: 22339
Location & Maps
more
  • Sequence Map
    Chr17:46016993-46032369 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      15377 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.79 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    VEGFA, vascular endothelial growth factor A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    VEGFA, vascular endothelial growth factor A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MVCD1, VEGF, VPF
  • Links
    NCBI Gene ID: 7422
    neXtProt AC: NX_P15692

  • Chr Location
    6p12; chr6:43770209-43786487 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    3 with Vegfa mouse models; 2 with human VEGFA associations

Human Disease Mouse Models
       Amyotrophic Lateral Sclerosis 1; ALS1   OMIM: 105400 View 1 model
DiGeorge Syndrome; DGS   OMIM: 188400 View 2 models
Respiratory Distress Syndrome in Premature Infants   OMIM: 267450 View 1 model
       Microvascular Complications of Diabetes, Susceptibility to, 1; MVCD1   OMIM: 603933
Vascular Endothelial Growth Factor A; VEGFA   OMIM: 192240
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    262 phenotypes from 14 alleles in 22 genetic backgrounds
    18 phenotypes from multigenic genotypes
    173 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Gene trapped
    1
  • Targeted
    15
  • Transgenic
    5
  • Incidental Mutations
    APF
Hetero- or homozygous null mutants show embryonic lethality with impaired angiogenesis and blood-island formation. Mutants selectively expressing isoform 120 or 188 exhibit vascular outgrowth/patterning defects or impaired arterial development, respectively.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    182
  • GO References
    52
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    493
  • Tissues
    279
  • cDNA Data
    85
  • Literature Summary
    358
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016285 VEGA Gene Model | MGI Sequence Detail 15377 C57BL/6J ±  kb
transcript OTTMUST00000039104 VEGA | MGI Sequence Detail 1973 Not Applicable  
polypeptide OTTMUSP00000017464 VEGA | MGI Sequence Detail 392 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    207 from dbSNP Build 142
  • PCR
    1
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000017284 vascular endothelial growth factor A
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR000072 PDGF/VEGF domain
    IPR023581 Platelet-derived growth factor, conserved site
    IPR027928 Vascular endothelial growth factor, heparin-binding domain
Molecular
Reagents
less
  • All nucleic 123
    Genomic 3
    cDNA 89
    Primer pair 28
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-24046
References
more
  • Summaries
    All 641
    Developmental Gene Expression 358
    Diseases 3
    Gene Ontology 52
    Phenotypes 173
  • Earliest
    J:27451 Breier G, et al., Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 1992 Feb;114(2):521-32
  • Latest
    J:232444 Li S, et al., Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory