Automated description from the Alliance of Genome Resources (Release 8.3.0)
Enables extracellular matrix binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including circulatory system development; generation of neurons; and regulation of signal transduction. Acts upstream of or within several processes, including circulatory system development; eye development; and positive regulation of cell population proliferation. Located in cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and heart. Used to study DiGeorge syndrome; amyotrophic lateral sclerosis type 1; newborn respiratory distress syndrome; and psoriasis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and retinal disease (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
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