Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMAD1
  • Mouse genes Smad1
  • Rat genes Smad1
  • Zfish genes smad1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smad1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070410	co-SMAD binding	SMAD1	IPI	UniProtKB:Q13485	Human	PMID:9111321
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	SMAD1	IPI	UniProtKB:P17844	Human	PMID:18548003
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	SMAD1	IDA		Human	PMID:12270938
Molecular Function	GO:0003700	DNA-binding transcription factor activity	SMAD1	IDA		Human	PMID:9389648
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Smad1	IDA		Mouse	PMID:14633973
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Smad1	IDA		Mouse	PMID:16556916
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Smad1	IDA		Mouse	PMID:21976273
Molecular Function	GO:0070411	I-SMAD binding	SMAD1	IPI	UniProtKB:O43541	Human	PMID:9436979
Molecular Function	GO:0042802	identical protein binding	SMAD1	IPI	UniProtKB:Q15797	Human	PMID:11779505
Molecular Function	GO:0042802	identical protein binding	SMAD1	IPI	UniProtKB:Q15797	Human	PMID:15231748
Molecular Function	GO:0042802	identical protein binding	SMAD1	IPI	UniProtKB:Q15797	Human	PMID:9111321
Molecular Function	GO:0042802	identical protein binding	Smad1	IPI	PR:P70340	Mouse	PMID:21724602
Molecular Function	GO:0070878	primary miRNA binding	Smad1	IDA		Mouse	MGI:MGI:4939577|PMID:21145505
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9HCE7	Human	PMID:11278251
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q13485	Human	PMID:11779505
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:P28070	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q13485	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9HAU4	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9HCE7	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9Y2U8	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9Y2U8	Human	PMID:15647271
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9UNE7	Human	PMID:15781469
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:O14595	Human	PMID:16882717
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:O15194	Human	PMID:16882717
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9GZU7	Human	PMID:16882717
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:P10275	Human	PMID:17183365
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q13485	Human	PMID:17183365
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:P84550	Human	PMID:17292623
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:O15397	Human	PMID:17785517
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:P17844	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9NRR4	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:P46937	Human	PMID:19914168
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9HCE7	Human	PMID:19914168
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9HAU4	Human	PMID:20937913
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:P15374	Human	PMID:21453705
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9HCE7-2	Human	PMID:21708152
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9Y4E8	Human	PMID:21947082
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q13485	Human	PMID:24412244
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:A6ND36	Human	PMID:24554596
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q86VV4	Human	PMID:25755279
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q8N1F7	Human	PMID:26878725
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9HAU4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q13485	Human	PMID:31467278
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:O95208-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:P28070	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q13485	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9HAU4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q9Y2U8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:O43541	Human	PMID:9436979
Molecular Function	GO:0005515	protein binding	SMAD1	IPI	UniProtKB:Q13485	Human	PMID:9436979
Molecular Function	GO:0005515	protein binding	Smad1	IPI	UniProtKB:Q6PDH4	Mouse	MGI:MGI:5883200|PMID:25755279
Molecular Function	GO:0005515	protein binding	Smad1	IPI	UniProtKB:Q62073	Mouse	MGI:MGI:3851881|PMID:19536134
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:Q9QZH6	Mouse	PMID:14633973
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:A7M7C7	Mouse	PMID:21937600
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:Q9R0G7	Mouse	PMID:16511561
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:Q8CHP0	Mouse	PMID:16511561
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:O88559	Mouse	PMID:15150273
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:P97471	Mouse	PMID:21724602
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:Q04211	Mouse	PMID:15542835
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:Q8R138	Mouse	PMID:21239498
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:Q8BGV5	Mouse	PMID:12370310
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:Q9CZA5	Mouse	PMID:19416967
Molecular Function	GO:0005515	protein binding	Smad1	IPI	PR:Q9JL10	Mouse	PMID:24211589
Molecular Function	GO:0005515	protein binding	Smad1	IPI	RGD:2581	Rat	PMID:12552124|RGD:629544
Molecular Function	GO:0005515	protein binding	smad1	IPI	ZFIN:ZDB-GENE-990603-8	Zfish	PMID:24488494
Molecular Function	GO:0019901	protein kinase binding	SMAD1	IPI	UniProtKB:Q9H2X6	Human	PMID:12874272
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SMAD1	IDA		Human	PMID:12270938
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SMAD1	IDA		Human	PMID:20147459
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Smad1	IDA		Mouse	PMID:18692037
Molecular Function	GO:0043565	sequence-specific DNA binding	Smad1	IDA		Mouse	MGI:MGI:5882869|PMID:23169531
Molecular Function	GO:0000976	transcription cis-regulatory region binding	smad1	IDA		Zfish	PMID:32064309
Cellular Component	GO:0005737	cytoplasm	SMAD1	IDA		Human	PMID:9389648
Cellular Component	GO:0005737	cytoplasm	Smad1	IDA		Mouse	MGI:MGI:5009194|PMID:11160896
Cellular Component	GO:0005737	cytoplasm	Smad1	IDA		Mouse	MGI:MGI:4352622|PMID:19252488
Cellular Component	GO:0005737	cytoplasm	Smad1	IDA		Mouse	PMID:19103752
Cellular Component	GO:0005737	cytoplasm	Smad1	IDA		Rat	PMID:17696121|RGD:1643225
Cellular Component	GO:0071144	heteromeric SMAD protein complex	SMAD1	IPI		Human	PMID:11779505
Cellular Component	GO:0071142	homomeric SMAD protein complex	SMAD1	IPI		Human	PMID:11779505
Cellular Component	GO:0071142	homomeric SMAD protein complex	Smad1	IPI		Mouse	MGI:MGI:5014035|PMID:20147459
Cellular Component	GO:0005637	nuclear inner membrane	SMAD1	IDA		Human	PMID:15647271
Cellular Component	GO:0005634	nucleus	SMAD1	IDA		Human	PMID:8653785
Cellular Component	GO:0005634	nucleus	SMAD1	IDA		Human	PMID:9389648
Cellular Component	GO:0005634	nucleus	Smad1	IDA		Mouse	MGI:MGI:4352622|PMID:19252488
Cellular Component	GO:0005634	nucleus	Smad1	IDA		Mouse	MGI:MGI:3693397|PMID:12151307
Cellular Component	GO:0005634	nucleus	Smad1	IDA		Mouse	PMID:21976273
Cellular Component	GO:0005634	nucleus	Smad1	IDA		Mouse	PMID:25100727
Cellular Component	GO:0005634	nucleus	Smad1	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Smad1	IDA		Mouse	PMID:19793887
Cellular Component	GO:0005634	nucleus	Smad1	IDA		Mouse	PMID:19103752
Cellular Component	GO:0005634	nucleus	Smad1	IDA		Rat	PMID:17696121|RGD:1643225
Cellular Component	GO:0032991	protein-containing complex	SMAD1	IDA		Human	PMID:23610558
Cellular Component	GO:0005667	transcription regulator complex	Smad1	IDA		Mouse	PMID:14633973
Biological Process	GO:0030509	BMP signaling pathway	SMAD1	IDA		Human	PMID:18548003
Biological Process	GO:0030509	BMP signaling pathway	SMAD1	IMP		Human	PMID:19664780
Biological Process	GO:0030509	BMP signaling pathway	SMAD1	IDA		Human	PMID:8637600
Biological Process	GO:0030509	BMP signaling pathway	SMAD1	IDA		Human	PMID:8653785
Biological Process	GO:0030509	BMP signaling pathway	SMAD1	IDA		Human	PMID:9389648
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IGI	UniProtKB:P97454	Mouse	MGI:MGI:5487530|PMID:20843790
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IGI	UniProtKB:P20722	Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IDA		Mouse	PMID:21976273
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IGI	MGI:MGI:107191	Mouse	PMID:16604073
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IDA		Mouse	PMID:25100727
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IMP	MGI:MGI:3045218	Mouse	PMID:15198985
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IGI	MGI:MGI:1328787	Mouse	PMID:19224984
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IGI	MGI:MGI:88177	Mouse	PMID:16604073
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IGI	MGI:MGI:1916835	Mouse	PMID:16604073
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IGI	MGI:MGI:1859993	Mouse	PMID:19224984
Biological Process	GO:0030509	BMP signaling pathway	Smad1	IMP		Rat	PMID:16020542|RGD:1643232
Biological Process	GO:0030509	BMP signaling pathway	smad1	IGI	ZFIN:ZDB-GENE-980526-474	Zfish	PMID:10590480|ZFIN:ZDB-PUB-991115-2
Biological Process	GO:0060348	bone development	Smad1	IGI	MGI:MGI:1859993	Mouse	PMID:19224984
Biological Process	GO:0060348	bone development	Smad1	IGI	MGI:MGI:1328787	Mouse	PMID:19224984
Biological Process	GO:0060038	cardiac muscle cell proliferation	Smad1	IMP		Mouse	PMID:17350578
Biological Process	GO:0060038	cardiac muscle cell proliferation	Smad1	IGI	MGI:MGI:97350	Mouse	PMID:17350578
Biological Process	GO:0051216	cartilage development	Smad1	IGI	MGI:MGI:1859993	Mouse	PMID:19224984
Biological Process	GO:0051216	cartilage development	Smad1	IGI	MGI:MGI:1328787	Mouse	PMID:19224984
Biological Process	GO:0008283	cell population proliferation	Smad1	IMP	MGI:MGI:2157982	Mouse	PMID:15899870
Biological Process	GO:0071773	cellular response to BMP stimulus	Smad1	IGI	UniProtKB:P97454	Mouse	MGI:MGI:5487530|PMID:20843790
Biological Process	GO:0071407	cellular response to organic cyclic compound	Smad1	IDA		Mouse	PMID:19103752
Biological Process	GO:0006351	DNA-templated transcription	SMAD1	IDA		Human	PMID:11779505
Biological Process	GO:0009953	dorsal/ventral pattern formation	smad1	IGI	ZFIN:ZDB-MRPHLNO-041217-8,ZFIN:ZDB-MRPHLNO-140620-7	Zfish	PMID:24488494
Biological Process	GO:0009953	dorsal/ventral pattern formation	smad1	IGI	ZFIN:ZDB-MRPHLNO-140620-6,ZFIN:ZDB-MRPHLNO-140620-7	Zfish	PMID:24488494
Biological Process	GO:0009880	embryonic pattern specification	smad1	IMP		Zfish	PMID:10590480|ZFIN:ZDB-PUB-991115-2
Biological Process	GO:0007276	gamete generation	Smad1	IMP	MGI:MGI:3045219	Mouse	PMID:15198985
Biological Process	GO:0030902	hindbrain development	Smad1	IMP	MGI:MGI:2157982	Mouse	PMID:15899870
Biological Process	GO:0042592	homeostatic process	Smad1	IMP	MGI:MGI:3045218	Mouse	PMID:15198985
Biological Process	GO:0006954	inflammatory response	Smad1	IEP		Mouse	MGI:MGI:3693397|PMID:12151307
Biological Process	GO:0001822	kidney development	Smad1	IEP		Rat	PMID:11850197|RGD:1643238
Biological Process	GO:0000165	MAPK cascade	Smad1	IMP	MGI:MGI:3045219	Mouse	PMID:15198985
Biological Process	GO:0000165	MAPK cascade	Smad1	IMP		Rat	PMID:16427075|RGD:1643230
Biological Process	GO:0001710	mesodermal cell fate commitment	Smad1	IGI	MGI:MGI:1919200	Mouse	PMID:16801560
Biological Process	GO:0030901	midbrain development	Smad1	IMP	MGI:MGI:2157982	Mouse	PMID:15899870
Biological Process	GO:0061515	myeloid cell development	smad1	IMP	ZFIN:ZDB-MRPHLNO-140620-7	Zfish	PMID:24488494
Biological Process	GO:0008285	negative regulation of cell population proliferation	Smad1	IMP	MGI:MGI:2157982	Mouse	PMID:15899870
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	smad1	IDA		Zfish	PMID:24488494
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	Smad1	IEP		Rat	PMID:11408477|RGD:1643239
Biological Process	GO:0051148	negative regulation of muscle cell differentiation	Smad1	IDA		Mouse	PMID:21976273
Biological Process	GO:0001649	osteoblast differentiation	SMAD1	IGI	RNAcentral:URS0000446722_9606	Human	PMID:25012146
Biological Process	GO:0001649	osteoblast differentiation	Smad1	IDA		Mouse	PMID:7798324
Biological Process	GO:0002051	osteoblast fate commitment	Smad1	IGI	MGI:MGI:1316736	Mouse	PMID:15150273
Biological Process	GO:0061036	positive regulation of cartilage development	Smad1	IDA		Mouse	PMID:19251704
Biological Process	GO:0045597	positive regulation of cell differentiation	Smad1	IDA		Rat	PMID:17525996|RGD:1643226
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Smad1	IEP		Rat	PMID:15056710|RGD:1643236
Biological Process	GO:0010628	positive regulation of gene expression	SMAD1	IDA		Human	PMID:19664780
Biological Process	GO:0010628	positive regulation of gene expression	Smad1	IMP	MGI:MGI:3805956	Mouse	PMID:18622394
Biological Process	GO:1902895	positive regulation of miRNA transcription	Smad1	IMP		Mouse	MGI:MGI:4939577|PMID:21145505
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Smad1	IGI	MGI:MGI:1316736	Mouse	PMID:15150273
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	SMAD1	IMP		Human	PMID:24047927
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SMAD1	IDA		Human	PMID:12270938
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad1	IDA		Mouse	PMID:16556916
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad1	IGI	MGI:MGI:1913438	Mouse	PMID:24211589
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad1	IDA		Mouse	PMID:18997172
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad1	IDA		Mouse	PMID:15557274
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad1	IDA		Mouse	PMID:19251704
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	Smad1	IGI	UniProtKB:P97454	Mouse	MGI:MGI:5487530|PMID:20843790
Biological Process	GO:0006468	protein phosphorylation	Smad1	IDA		Mouse	PMID:18776146
Biological Process	GO:0006355	regulation of DNA-templated transcription	smad1	IDA		Zfish	PMID:32064309
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Smad1	IDA		Mouse	PMID:12270938
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Smad1	IDA		Mouse	PMID:14633973
Biological Process	GO:0010243	response to organonitrogen compound	Smad1	IEP		Rat	PMID:16166221|RGD:1643231
Biological Process	GO:0009410	response to xenobiotic stimulus	Smad1	IDA		Rat	PMID:18079356|RGD:1643223
Biological Process	GO:0007183	SMAD protein complex assembly	SMAD1	IDA		Human	PMID:9111321
Biological Process	GO:0060395	SMAD protein signal transduction	SMAD1	IGI	RNAcentral:URS0000446722_9606	Human	PMID:25012146
Biological Process	GO:0060395	SMAD protein signal transduction	Smad1	IGI	UniProtKB:P20722	Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0006366	transcription by RNA polymerase II	Smad1	IDA		Mouse	PMID:18997172
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	SMAD1	IDA		Human	PMID:9389648
Biological Process	GO:0001657	ureteric bud development	Smad1	IEP		Mouse	MGI:MGI:3525982|PMID:14656760
Biological Process	GO:0042060	wound healing	Smad1	IEP		Rat	PMID:11920662|RGD:724455

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern