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Smad1
Gene Detail
 Symbol
Name
ID
Smad1
SMAD family member 1
MGI:109452
Synonyms Madh1, Madr1, Smad 1
Feature Type protein coding gene
Genetic Map
Chromosome 8
37.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:79338395-79399518 bp, - strand
From VEGA annotation of GRCm38

  61124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21196  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Smad protein
Gene Tree: Smad1

Human
homologs
Human Homolog SMAD1, SMAD family member 1
NCBI Gene ID 4086
neXtProt AC  NX_Q15797
Human Synonyms  BSP1, BSP-1, JV41, JV4-1, MADH1, MADR1
Human Chr (Location)  4q31; chr4:145481306-145559176 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(5) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired allantois formation resulting in the lack of a placenta, and die around embryonic day 9-10.
 
Human Diseases Modeled Using Mouse Smad1 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Smad1 interacts with 297 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process BMP signaling pathway, bone development, ...
Component cytoplasm, intracellular, ...
Function co-SMAD binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (296 records)
Data Summary: Results (475)    Tissues (313)    Images (100)
Theiler Stages: 1, 2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 76
RNA in situ 291
Northern blot 6
Western blot 10
RT-PCR 92
cDNA source data(70)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(88) cDNA(76) Primer pair(10) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021109 (Evidence)
Ensembl Gene ModelENSMUSG00000031681 (Evidence)
Entrez Gene17125 (Evidence)
UniGene223717
DFCITC1574892
DoTSDT.101141947, DT.101708497, DT.91508201
NIA Mouse Gene IndexU029992
PDB3KMP
Consensus CDS ProjectCCDS22437.1
International Mouse Knockout Project StatusSmad1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021109 VEGA Gene Model | MGI Sequence Detail 61124 C57BL/6J ±  kb
transcript OTTMUST00000049956 VEGA | MGI Sequence Detail 3099 Not Applicable 
polypeptide OTTMUSP00000023243 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(209 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013790 Dwarfin
InterPro IPR003619 MAD homology 1, Dwarfin-type
InterPro IPR013019 MAD homology, MH1
InterPro IPR001132 SMAD domain, Dwarfin-type
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000000363 smad1
References (Earliest) J:51722 Yingling JM, et al., Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8940-4
(Latest) J:209351 Prashar P, et al., Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014 May 15;389(2):192-207
All references(384)
Other
accession IDs
MGD-MRK-38497, MGI:2142582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory