Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and nucleic acid binding activity. Involved in several processes, including osteoblast differentiation; positive regulation of miRNA transcription; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including brain development; positive regulation of macromolecule biosynthetic process; and skeletal system development. Located in cytoplasm and nucleus. Part of homomeric SMAD protein complex and transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; embryo mesenchyme; genitourinary system; and nervous system. Orthologous to human SMAD1 (SMAD family member 1).