Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pik3r1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PIK3R1
- Mouse genes Pik3r1
- Rat genes Pik3r1
- Zfish genes pik3r1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pik3r1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3r1	IDA		Rat	PMID:20236230\|RGD:4107732
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	Pik3r1	IDA		Mouse	PMID:7534300
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	Pik3r1	IDA		Mouse	PMID:7542745
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	Pik3r1	IMP		Mouse	PMID:11784871
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	Pik3r1	IDA		Rat	PMID:12882977\|RGD:4144086
Molecular Function	GO:0051117	ATPase binding	Pik3r1	IPI	RGD:2167	Rat	PMID:17728397\|RGD:4108501
Molecular Function	GO:0005516	calmodulin binding	Pik3r1	IPI	RGD:2257	Rat	PMID:17492691\|RGD:4108506
Molecular Function	GO:0043125	ErbB-3 class receptor binding	PIK3R1	IDA		Human	PMID:10572067
Molecular Function	GO:0043559	insulin binding	PIK3R1	IDA		Human	PMID:8440175
Molecular Function	GO:0005158	insulin receptor binding	PIK3R1	IPI	UniProtKB:P06213	Human	PMID:7537849
Molecular Function	GO:0043560	insulin receptor substrate binding	Pik3r1	IPI	UniProtKB:P35568	Mouse	MGI:MGI:3689804\|PMID:16043515
Molecular Function	GO:0043560	insulin receptor substrate binding	Pik3r1	IPI	RGD:2922	Rat	PMID:12891559\|RGD:1299201
Molecular Function	GO:0043560	insulin receptor substrate binding	Pik3r1	IPI	RGD:69316	Rat	PMID:12891559\|RGD:1299201
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	PIK3R1	IPI	UniProtKB:P08069	Human	PMID:7541045
Molecular Function	GO:0019209	kinase activator activity	Pik3r1	IDA		Mouse	PMID:7534300
Molecular Function	GO:0019209	kinase activator activity	Pik3r1	IDA		Mouse	PMID:7542745
Molecular Function	GO:0019209	kinase activator activity	Pik3r1	IMP		Mouse	PMID:11784871
Molecular Function	GO:0005168	neurotrophin TRKA receptor binding	PIK3R1	IPI	UniProtKB:P04629	Human	PMID:15488758
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Pik3r1	IPI	RGD:2581	Rat	PMID:16971528\|RGD:1625219
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Pik3r1	IPI	UniProtKB:O08908	Mouse	MGI:MGI:4442277\|PMID:20348926
Molecular Function	GO:0051219	phosphoprotein binding	Pik3r1	IPI	RGD:628770	Rat	PMID:12882964\|RGD:1299347
Molecular Function	GO:0001784	phosphotyrosine residue binding	PIK3R1	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	Pik3r1	IPI	RGD:3284\|RGD:3285	Rat	PMID:18421086\|RGD:4108491
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P06213	Human	PMID:10500481
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P21860	Human	PMID:10572067
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35570	Human	PMID:10660596
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:10752619
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:O43561	Human	PMID:10811803
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10747	Human	PMID:10820259
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q13480	Human	PMID:10978177
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P0DOJ9	Human	PMID:11123912
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35568	Human	PMID:11403293
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35568	Human	PMID:11416002
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:11710529
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P06213	Human	PMID:11796522
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:11896612
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:1314164
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:1330535
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35570	Human	PMID:1380456
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10721	Human	PMID:1382595
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35568	Human	PMID:14632132
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:16043515
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35568	Human	PMID:16230374
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P21860	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q13480	Human	PMID:16638574
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P04626	Human	PMID:16843263
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:O15455	Human	PMID:16858407
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P30874	Human	PMID:16917505
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P22681	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P36888	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P45983	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9UKW4	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P26373	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P41970	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42684	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q07889	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q13111	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q13905	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q15661	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q8WX92	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q92918	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9ULW0	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9UPX8	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9Y2H0	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q99152	Human	PMID:18059340
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:18079394
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P11362	Human	PMID:18412956
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10747	Human	PMID:18641334
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9Y6W8	Human	PMID:18641334
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P22681	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P46108	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P62993	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:19574958
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P58753	Human	PMID:19574958
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:19805105
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P48023	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:19864249
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P12931	Human	PMID:19903481
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P21860	Human	PMID:20007781
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:20018188
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q8IY22	Human	PMID:20018188
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P21860	Human	PMID:20227043
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P17861-2	Human	PMID:20348923
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P19793	Human	PMID:20541701
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q8IZP0	Human	PMID:20598684
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q86VI4-3	Human	PMID:20711237
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:20713702
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42338	Human	PMID:20713702
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P62993	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P04626	Human	PMID:21075308
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P21860	Human	PMID:21075308
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q96EB6	Human	PMID:21241768
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9Y4H2	Human	PMID:21241768
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P21860	Human	PMID:21278786
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:O00329	Human	PMID:21827948
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q6PFX7	Human	PMID:21946561
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q8BM65-4	Human	PMID:21946561
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q3V6T2	Human	PMID:21954290
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:O00329	Human	PMID:22020336
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:22402981
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P21860	Human	PMID:22439932
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P03496	Human	PMID:22810585
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P12931	Human	PMID:23065768
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q13322	Human	PMID:23246379
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42858	Human	PMID:23275563
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P12931	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P17948	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9UKC9	Human	PMID:23604317
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9Y4H2	Human	PMID:23617393
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35568	Human	PMID:23643389
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:23643389
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q5T0W9	Human	PMID:23676467
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P03496	Human	PMID:23853584
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:O00329	Human	PMID:24165795
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P21860	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P12931	Human	PMID:24498420
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P00533	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P08069	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10721	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P11362	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P12931	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42338	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P46108	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P48023	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q07889	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:25253337
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P45983	Human	PMID:25284480
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P41970	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P62993	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09917	Human	PMID:26210919
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P25942	Human	PMID:26210919
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42338	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q13111	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9Y4H2	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9Y6W8	Human	PMID:27135603
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9H0K1	Human	PMID:27478041
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P03496	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:O00329	Human	PMID:31031754
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42338	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P42336	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P46108	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P04626	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P04629	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P06213	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P08069	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P11362	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P30530	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:7536927
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10721	Human	PMID:7537096
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10747	Human	PMID:7568038
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10747	Human	PMID:7584133
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P08069	Human	PMID:7589433
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P08069	Human	PMID:7642582
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P17948	Human	PMID:7657594
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35568	Human	PMID:7680095
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:7680644
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35568	Human	PMID:7680644
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:7692233
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35568	Human	PMID:7782332
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P00533	Human	PMID:7797556
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10747	Human	PMID:7807015
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P16410	Human	PMID:7807015
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10747	Human	PMID:8146197
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10747	Human	PMID:8183372
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P04629	Human	PMID:8226808
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q9PVZ4	Human	PMID:8276809
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:8382612
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P35568	Human	PMID:8382612
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:8564419
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P08069	Human	PMID:8603569
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:8670861
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P06241	Human	PMID:8961927
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P09619	Human	PMID:9153411
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P22681	Human	PMID:9160881
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P30530	Human	PMID:9178760
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P16410	Human	PMID:9398332
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P10747	Human	PMID:9417079
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P06213	Human	PMID:9593725
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:Q13480	Human	PMID:9658397
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P16410	Human	PMID:9813138
Molecular Function	GO:0005515	protein binding	PIK3R1	IPI	UniProtKB:P22681	Human	PMID:9890970
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:Q8R5H6	Mouse	MGI:MGI:5304984\|PMID:21946561
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:Q8IZP0	Mouse	MGI:MGI:5508738\|PMID:20598684
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:O35904-2	Mouse	MGI:MGI:5487514\|PMID:22020336
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P42337\|UniProtKB:Q8BTI9	Mouse	MGI:MGI:3795660\|PMID:18449193
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:O08908\|UniProtKB:O35426-2	Mouse	MGI:MGI:4442277\|PMID:20348926
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P35569	Mouse	MGI:MGI:5512948\|PMID:20804756
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P05622	Mouse	MGI:MGI:5009204\|PMID:10644978
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P35569	Mouse	MGI:MGI:3771752\|PMID:18059474
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:O88665\|UniProtKB:P42337\|UniProtKB:Q62448\|UniProtKB:Q8BTI9	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:Q9WVS0	Mouse	MGI:MGI:6120056\|PMID:27135603
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:Q5DTU0	Mouse	MGI:MGI:6285442\|PMID:30667096
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:Q8K3G9,UniProtKB:Q8K3H0	Mouse	MGI:MGI:5698780\|PMID:25328665
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P35569	Mouse	MGI:MGI:3776676\|PMID:18296638
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:P49769	Mouse	PMID:15192701
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:Q9Z1S8	Mouse	PMID:11895767
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:P81122	Mouse	PMID:26657864
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:Q9EQ32	Mouse	PMID:11163197
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:P81122	Mouse	PMID:23775122
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:Q6SP97	Mouse	PMID:15385169
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:Q9QYY0	Mouse	PMID:12808090
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:Q9D828	Mouse	PMID:11591653
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:Q60974	Mouse	PMID:17606624
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:Q9EQR5	Mouse	PMID:16249387
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:P37242	Mouse	PMID:17606624
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:Q9JLY0	Mouse	PMID:12052866
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	PR:P34152	Mouse	PMID:25217619
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:Q91V33	Rat	PMID:10437794\|RGD:8553603
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P35570	Rat	PMID:11136729\|RGD:8553709
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P35570	Rat	PMID:12446583\|RGD:8553525
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	RGD:2406	Rat	PMID:12692262\|RGD:1304375
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P18545	Rat	PMID:16357825\|RGD:8554657
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P62813	Rat	PMID:16890252\|RGD:8554051
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:A0MZ67	Rat	PMID:17030985\|RGD:8554246
Molecular Function	GO:0005515	protein binding	Pik3r1	IPI	UniProtKB:P21575	Rat	PMID:17437541\|RGD:8554440
Molecular Function	GO:0019904	protein domain specific binding	Pik3r1	IPI	RGD:619758	Rat	PMID:10973965\|RGD:2303503
Molecular Function	GO:0019904	protein domain specific binding	Pik3r1	IPI	RGD:621367	Rat	PMID:10973965\|RGD:2303503
Molecular Function	GO:0046982	protein heterodimerization activity	Pik3r1	IPI	UniProtKB:O08908	Mouse	MGI:MGI:4442277\|PMID:20348926
Molecular Function	GO:0019901	protein kinase binding	Pik3r1	IPI	RGD:2939	Rat	PMID:15530849\|RGD:1641930
Molecular Function	GO:0019901	protein kinase binding	Pik3r1	IPI	RGD:3443	Rat	PMID:18854312\|RGD:4108485
Molecular Function	GO:0019903	protein phosphatase binding	PIK3R1	IPI	UniProtKB:Q12959	Human	PMID:14699157
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Pik3r1	IPI	RGD:620028	Rat	PMID:18292389\|RGD:4108493
Molecular Function	GO:0005102	signaling receptor binding	Pik3r1	IPI	RGD:3870	Rat	PMID:14962484\|RGD:1302746
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Pik3r1	IPI	RGD:1561386	Rat	PMID:18773943\|RGD:4108486
Cellular Component	GO:0005911	cell-cell junction	Pik3r1	IDA		Mouse	PMID:23793062
Cellular Component	GO:0005801	cis-Golgi network	Pik3r1	IDA		Mouse	PMID:25217619
Cellular Component	GO:0005737	cytoplasm	PIK3R1	IDA		Human	PMID:20348923
Cellular Component	GO:0005737	cytoplasm	Pik3r1	IDA		Mouse	MGI:MGI:3689804\|PMID:16043515
Cellular Component	GO:0005829	cytosol	Pik3r1	IDA		Mouse	MGI:MGI:3689804\|PMID:16043515
Cellular Component	GO:0016020	membrane	PIK3R1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Pik3r1	IDA		Mouse	MGI:MGI:3689804\|PMID:16043515
Cellular Component	GO:0016020	membrane	Pik3r1	IDA		Rat	PMID:20519555\|RGD:4107731
Cellular Component	GO:0043005	neuron projection	Pik3r1	IDA		Rat	PMID:17600839\|RGD:4108504
Cellular Component	GO:0005634	nucleus	Pik3r1	IDA		Mouse	MGI:MGI:4442277\|PMID:20348926
Cellular Component	GO:0005634	nucleus	Pik3r1	IDA		Rat	PMID:17918740\|RGD:4108495
Cellular Component	GO:1990578	perinuclear endoplasmic reticulum membrane	Pik3r1	IDA		Mouse	PMID:25217619
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Pik3r1	IDA		Mouse	MGI:MGI:6450670\|PMID:11038173
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	Pik3r1	IDA		Rat	PMID:12882977\|RGD:4144086
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	Pik3r1	IDA		Rat	PMID:20236230\|RGD:4107732
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3R1	IPI		Human	PMID:19805105
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3R1	IPI		Human	PMID:20713702
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3R1	IPI		Human	PMID:28108251
Cellular Component	GO:0005886	plasma membrane	Pik3r1	IDA		Rat	PMID:11826414\|RGD:1625216
Cellular Component	GO:0032991	protein-containing complex	Pik3r1	IDA		Mouse	PMID:26657864
Cellular Component	GO:0032991	protein-containing complex	Pik3r1	IDA		Rat	PMID:10973965\|RGD:2303503
Biological Process	GO:0007568	aging	Pik3r1	IEP		Rat	PMID:16123202\|RGD:1625220
Biological Process	GO:0030183	B cell differentiation	Pik3r1	IMP	MGI:MGI:2149414	Mouse	PMID:9988280
Biological Process	GO:0071398	cellular response to fatty acid	Pik3r1	IEP		Rat	PMID:17593346\|RGD:4108505
Biological Process	GO:0032869	cellular response to insulin stimulus	Pik3r1	IDA		Mouse	MGI:MGI:4442277\|PMID:20348926
Biological Process	GO:0032869	cellular response to insulin stimulus	Pik3r1	IDA		Mouse	PMID:26657864
Biological Process	GO:0032869	cellular response to insulin stimulus	Pik3r1	IEP		Rat	PMID:18922131\|RGD:4108484
Biological Process	GO:0034644	cellular response to UV	Pik3r1	IGI	MGI:MGI:103296	Mouse	PMID:17242187
Biological Process	GO:0034644	cellular response to UV	Pik3r1	IMP	MGI:MGI:2149414	Mouse	PMID:17242187
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Pik3r1	IMP		Mouse	PMID:15039234
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Pik3r1	IGI	MGI:MGI:97306	Mouse	PMID:15039234
Biological Process	GO:0006006	glucose metabolic process	Pik3r1	IMP		Rat	PMID:9440811\|RGD:1625263
Biological Process	GO:0060396	growth hormone receptor signaling pathway	PIK3R1	IDA		Human	PMID:7782332
Biological Process	GO:0008286	insulin receptor signaling pathway	Pik3r1	IMP		Mouse	MGI:MGI:4442277\|PMID:20348926
Biological Process	GO:0008286	insulin receptor signaling pathway	Pik3r1	IDA		Mouse	PMID:7534300
Biological Process	GO:0008286	insulin receptor signaling pathway	Pik3r1	IDA		Mouse	PMID:7542745
Biological Process	GO:0008286	insulin receptor signaling pathway	Pik3r1	IMP		Rat	PMID:15161606\|RGD:1625251
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	PIK3R1	IPI	UniProtKB:P08069	Human	PMID:7541045
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	PIK3R1	IDA		Human	PMID:7782332
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Pik3r1	IMP		Mouse	PMID:11784871
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Pik3r1	IDA		Mouse	PMID:33567274
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Pik3r1	IMP		Rat	PMID:9440811\|RGD:1625263
Biological Process	GO:0001678	intracellular glucose homeostasis	Pik3r1	IDA		Mouse	MGI:MGI:4442277\|PMID:20348926
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Pik3r1	IGI	MGI:MGI:104798	Mouse	PMID:17242187
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Pik3r1	IMP	MGI:MGI:2149414	Mouse	PMID:17242187
Biological Process	GO:0097529	myeloid leukocyte migration	Pik3r1	IGI	MGI:MGI:97306	Mouse	PMID:17053831
Biological Process	GO:0043066	negative regulation of apoptotic process	PIK3R1	IMP		Human	PMID:20348923
Biological Process	GO:0043066	negative regulation of apoptotic process	Pik3r1	IDA		Mouse	PMID:15192701
Biological Process	GO:0045776	negative regulation of blood pressure	Pik3r1	IMP		Rat	PMID:19015400\|RGD:4108483
Biological Process	GO:0007162	negative regulation of cell adhesion	Pik3r1	IDA		Mouse	PMID:25217619
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	Pik3r1	IMP		Rat	PMID:15530849\|RGD:1641930
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	Pik3r1	IGI	MGI:MGI:97306	Mouse	PMID:17053831
Biological Process	GO:0010459	negative regulation of heart rate	Pik3r1	IMP		Rat	PMID:19015400\|RGD:4108483
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	Pik3r1	IMP		Rat	PMID:15089039\|RGD:1625255
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Pik3r1	IGI	MGI:MGI:97306	Mouse	PMID:17053831
Biological Process	GO:0045861	negative regulation of proteolysis	Pik3r1	IMP		Rat	PMID:15161606\|RGD:1625251
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Pik3r1	IMP		Rat	PMID:19783773\|RGD:4107736
Biological Process	GO:0051497	negative regulation of stress fiber assembly	Pik3r1	IDA		Mouse	MGI:MGI:6450670\|PMID:11038173
Biological Process	GO:0030316	osteoclast differentiation	Pik3r1	IGI	MGI:MGI:97306	Mouse	PMID:17053831
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3R1	IMP		Human	PMID:21321938
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3R1	IDA		Human	PMID:7782332
Biological Process	GO:0030335	positive regulation of cell migration	Pik3r1	IMP		Rat	PMID:15530849\|RGD:1641930
Biological Process	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	PIK3R1	IMP		Human	PMID:20348923
Biological Process	GO:0051491	positive regulation of filopodium assembly	Pik3r1	IDA		Mouse	MGI:MGI:6450670\|PMID:11038173
Biological Process	GO:0120183	positive regulation of focal adhesion disassembly	Pik3r1	IDA		Mouse	MGI:MGI:6450670\|PMID:11038173
Biological Process	GO:0010628	positive regulation of gene expression	Pik3r1	IMP		Rat	PMID:20333648\|RGD:2324995
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	Pik3r1	IDA		Mouse	MGI:MGI:6450670\|PMID:11038173
Biological Process	GO:0002687	positive regulation of leukocyte migration	Pik3r1	IGI	MGI:MGI:97306	Mouse	PMID:17053831
Biological Process	GO:0045663	positive regulation of myoblast differentiation	Pik3r1	IMP		Rat	PMID:9440811\|RGD:1625263
Biological Process	GO:0042307	positive regulation of protein import into nucleus	PIK3R1	IDA		Human	PMID:20348923
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Pik3r1	IMP		Mouse	MGI:MGI:4442277\|PMID:20348926
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Pik3r1	IMP		Rat	PMID:19723872\|RGD:4107737
Biological Process	GO:0033120	positive regulation of RNA splicing	PIK3R1	IMP		Human	PMID:20348923
Biological Process	GO:0051965	positive regulation of synapse assembly	Pik3r1	IDA		Rat	PMID:21414895\|RGD:15023480
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PIK3R1	IMP		Human	PMID:20348923
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pik3r1	IDA		Mouse	MGI:MGI:4442277\|PMID:20348926
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pik3r1	IMP	MGI:MGI:2149414	Mouse	PMID:17242187
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Pik3r1	IMP		Mouse	PMID:17242187
Biological Process	GO:0006606	protein import into nucleus	Pik3r1	IMP	MGI:MGI:2149414	Mouse	PMID:17242187
Biological Process	GO:0006468	protein phosphorylation	Pik3r1	IDA		Mouse	PMID:15192701
Biological Process	GO:0050821	protein stabilization	PIK3R1	IDA		Human	PMID:20348923
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	Pik3r1	IGI	MGI:MGI:88315	Mouse	PMID:26657864
Biological Process	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	Pik3r1	IDA		Rat	PMID:12882977\|RGD:4144086
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	Pik3r1	IDA		Mouse	PMID:25217619
Biological Process	GO:0051492	regulation of stress fiber assembly	Pik3r1	IMP	MGI:MGI:2149438	Mouse	PMID:25217619
Biological Process	GO:0043200	response to amino acid	Pik3r1	IEP		Rat	PMID:19106217\|RGD:4108480
Biological Process	GO:0051591	response to cAMP	Pik3r1	IDA		Rat	PMID:10875243\|RGD:1625260
Biological Process	GO:0071548	response to dexamethasone	Pik3r1	IEP		Rat	PMID:20032058\|RGD:4107733
Biological Process	GO:0034976	response to endoplasmic reticulum stress	PIK3R1	IDA		Human	PMID:20348923
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Pik3r1	IDA		Mouse	MGI:MGI:4442277\|PMID:20348926
Biological Process	GO:0032355	response to estradiol	Pik3r1	IEP		Rat	PMID:19462258\|RGD:4108478
Biological Process	GO:0045471	response to ethanol	Pik3r1	IEP		Rat	PMID:17622585\|RGD:4108503
Biological Process	GO:0070542	response to fatty acid	Pik3r1	IEP		Rat	PMID:19369057\|RGD:4108479
Biological Process	GO:0009750	response to fructose	Pik3r1	IEP		Rat	PMID:17976658\|RGD:4108494
Biological Process	GO:0051384	response to glucocorticoid	Pik3r1	IDA		Rat	PMID:15187100\|RGD:1625221
Biological Process	GO:0070848	response to growth factor	Pik3r1	IEP		Rat	PMID:18421086\|RGD:4108491
Biological Process	GO:0032868	response to insulin	Pik3r1	IDA		Rat	PMID:16150536\|RGD:1625213
Biological Process	GO:0010040	response to iron(II) ion	Pik3r1	IEP		Rat	PMID:17600839\|RGD:4108504
Biological Process	GO:0007584	response to nutrient	Pik3r1	IEP		Rat	PMID:19657097\|RGD:4108477
Biological Process	GO:0007584	response to nutrient	Pik3r1	IEP		Rat	PMID:19880292\|RGD:4107735
Biological Process	GO:0032570	response to progesterone	Pik3r1	IEP		Rat	PMID:18752305\|RGD:4108487
Biological Process	GO:0033574	response to testosterone	Pik3r1	IEP		Rat	PMID:20032058\|RGD:4107733
Biological Process	GO:0009410	response to xenobiotic stimulus	Pik3r1	IEP		Rat	PMID:20519555\|RGD:4107731
Biological Process	GO:0001878	response to yeast	Pik3r1	IEP		Rat	PMID:19958054\|RGD:4107734
Biological Process	GO:0006366	transcription by RNA polymerase II	Pik3r1	IMP	MGI:MGI:2149414	Mouse	PMID:17242187
Biological Process	GO:0032640	tumor necrosis factor production	Pik3r1	IMP		Mouse	PMID:17242187

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.