Pik3r1
Gene Detail

Symbol Name ID

Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) MGI:97583

Synonyms

p50alpha, p55alpha, p85alpha, PI3K

Feature Type

protein coding gene

Genetic Map

Chromosome 13

53.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr13:101680761-101768217 bp, - strand From NCBI annotation of GRCm38   87457 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pik3r1 ± 2 cM)

Protein SuperFamily: phosphatidylinositol 3-kinase, regulatory subunit, p85 type
Gene Tree: Pik3r1

Human ortholog

PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) NCBI Gene ID 5295
Human Synonyms: GRB1, p85, p85-ALPHA
Human Chr5:67522462-67597649 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(28) : Targeted(8) Gene trapped(20)
 

Homozygotes for a targeted null mutation exhibit perinatal lethality associated with hepatic necrosis, chylous ascites, enlarged muscle fibers, calcification of cardiac tissue, and hypoglycemia. Mutants lacking only the major isoform are immunodeficient.

 
Human Diseases Modeled Using Mouse Pik3r1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (80 annotations)

Process	B cell differentiation, cellular response to UV, ...
Component	cytoplasm, cytosol, ...
Function	1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (304)    Tissues (177)    Images (43)
Theiler Stages: 2, 3, 19, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	234
Northern blot	25
Western blot	9
RT-PCR	36

cDNA source data(107)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(120) Genomic(9) cDNA(109) Primer pair(2)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000041417 (Evidence)
Entrez Gene	18708 (Evidence)
UniGene	259333
DFCI	TC1581848, TC1582013, TC1642133, TC1666508, TC1692216, TC1731222
DoTS	DT.101164583, DT.101356000, DT.110975228, DT.487883, DT.87034068
NIA Mouse Gene Index	U035123
Consensus CDS Project	CCDS26740.1, CCDS36769.1
International Mouse Knockout Project Status	Pik3r1

Sequences

Length	Strain/Species
genomic	18708	NCBI Gene Model | MGI Sequence Detail	87457	C57BL/6J
transcript	NM_001077495	RefSeq | MGI Sequence Detail	6915	C57BL/6
polypeptide	P26450	UniProt | EBI | MGI Sequence Detail	724	Not Applicable

All sequences(49) RefSeq(4) UniProt(7)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(336 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001720	PI3 kinase, P85 regulatory subunit
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
Protein Ontology	PR:000012724	phosphatidylinositol 3-kinase regulatory subunit alpha

Graphical View of Protein Domain Structure

References

(Earliest) J:17845 Escobedo JA, et al., cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell. 1991 Apr 5;65(1):75-82
(Latest) J:192532 Song S, et al., PDT-induced HSP70 externalization up-regulates NO production via TLR2 signal pathway in macrophages. FEBS Lett. 2013 Jan 16;587(2):128-35
All references(187)

Other accession IDs

MGD-MRK-13305, MGI:2145159