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Pik3r1
Gene Detail
 Symbol
Name
ID
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
MGI:97583
Synonyms p50alpha, p55alpha, p85alpha, PI3K
Feature Type protein coding gene
Genetic Map
Chromosome 13
53.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr13:101680761-101768217 bp, - strand
From NCBI annotation of GRCm38

  87457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7889  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase, regulatory subunit, p85 type
Gene Tree: Pik3r1

Human
homologs
Human Homolog PIK3R1, phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
NCBI Gene ID 5295
neXtProt AC  NX_P27986
Human Synonyms  AGM7, GRB1, p85, p85-ALPHA
Human Chr (Location)  5q13.1; chr5:68215756-68301821 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PIK3R1
Alleles
and
phenotypes
All alleles(28) : Targeted(8) Gene trapped(20)
 
Homozygotes for a targeted null mutation exhibit perinatal lethality associated with hepatic necrosis, chylous ascites, enlarged muscle fibers, calcification of cardiac tissue, and hypoglycemia. Mutants lacking only the major isoform are immunodeficient.
 
Human Diseases Modeled Using Mouse Pik3r1 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (94 annotations)
Process B cell differentiation, cellular response to UV, ...
Component cell, cell-cell junction, ...
Function 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (329)    Tissues (202)    Images (59)
Theiler Stages: 2, 3, 19, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 25
RNA in situ 234
Northern blot 25
Western blot 9
RT-PCR 36
cDNA source data(111)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(124) Genomic(9) cDNA(113) Primer pair(2)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000041417 (Evidence)
Entrez Gene18708 (Evidence)
UniGene259333
DFCITC1581848, TC1582013, TC1634552, TC1642133, TC1666508, TC1692216, TC1731222
DoTSDT.101164583, DT.101356000, DT.110975228, DT.487883, DT.87034068
NIA Mouse Gene IndexU035123
Consensus CDS ProjectCCDS26740.1, CCDS36769.1
International Mouse Knockout Project StatusPik3r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18708 NCBI Gene Model | MGI Sequence Detail 87457 C57BL/6J ±  kb
transcript NM_001077495 RefSeq | MGI Sequence Detail 6928 C57BL/6 
polypeptide P26450 UniProt | EBI | MGI Sequence Detail 724 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(8) UniProt(7)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(347 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001720 PI3 kinase, P85 regulatory subunit
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000012724 phosphatidylinositol 3-kinase regulatory subunit alpha
Graphical View of Protein Domain Structure
References (Earliest) J:17845 Escobedo JA, et al., cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell. 1991 Apr 5;65(1):75-82
(Latest) J:206472 Winnay JN, et al., p85alpha deficiency protects beta-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1192-7
All references(200)
Other
accession IDs
MGD-MRK-13305, MGI:2145159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory