About   Help   FAQ
Pik3r1
Gene Detail
Symbol

Name
ID
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
MGI:97583
Synonyms
p50alpha, p55alpha, p85alpha, PI3K
Feature Type
protein coding gene
Genetic Map
Chromosome 13
53.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr13:101680563-101768217 bp, - strand
From VEGA annotation of GRCm38

  87655 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7889  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIK3R1
Protein SuperFamily: phosphatidylinositol 3-kinase, regulatory subunit, p85 type
Gene Tree: Pik3r1

Human
homologs
PIK3R1, phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5295
neXtProt AC: NX_P27986

Human Synonyms: AGM7, GRB1, IMD36, p85, p85-ALPHA

Human Chr (Location): 5q13.1; chr5:68215756-68301821 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human PIK3R1

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(20) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit perinatal lethality associated with hepatic necrosis, chylous ascites, enlarged muscle fibers, calcification of cardiac tissue, and hypoglycemia. Mutants lacking only the major isoform are immunodeficient.
 
Human Diseases Modeled in Mice Using Pik3r1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Pik3r1 interacts with 458 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (22 records)
Data Summary: Results (329)    Tissues (205)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 25
RNA in situ 234
Northern blot 25
Western blot 9
RT-PCR 36
cDNA source data(111)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PIK3R1 ; Xenbase pik3r1 ; ZFIN pik3r1    NEW 
Molecular
reagents
All nucleic(124) Genomic(9) cDNA(113) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000048150 (Evidence)
Ensembl Gene Model ENSMUSG00000041417 (Evidence)
Entrez Gene 18708 (Evidence)
UniGene 259333
DFCI TC1581848, TC1582013, TC1634552, TC1642133, TC1666508, TC1692216, TC1731222
DoTS DT.101164583, DT.101356000, DT.110975228, DT.487883, DT.87034068
NIA Mouse Gene Index U035123
Consensus CDS Project CCDS26740.1, CCDS36769.1
International Mouse Phenotyping Consortium Status Pik3r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048150 VEGA Gene Model | MGI Sequence Detail 87655 C57BL/6J ±  kb
transcript OTTMUST00000123661 VEGA | MGI Sequence Detail 7113 Not Applicable 
polypeptide OTTMUSP00000067463 VEGA | MGI Sequence Detail 724 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(8) UniProt(8)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(348 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001720 PI3 kinase, P85 regulatory subunit
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000012724 phosphatidylinositol 3-kinase regulatory subunit alpha
References
(Earliest) J:17845 Escobedo JA, et al., cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell. 1991 Apr 5;65(1):75-82
(Latest) J:222609 Leavenworth JW, et al., A p85alpha-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells. Nat Immunol. 2015 Jan;16(1):96-106
All references(208)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-13305, MGI:2145159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory