Symbol
Name
ID

Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
MGI:97583

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Decreased circulating IgG level

Increased circulating IgM level

Agammaglobulinemia

Panhypogammaglobulinemia

Hyperglycemia

Glucose intolerance

Diabetes mellitus

Insulin-resistant diabetes mellitus

Type II diabetes mellitus

Insulin resistance

Persistent CMV viremia

Persistent EBV viremia

Disease(s) Associated with PIK3R1

agammaglobulinemia 7

immunodeficiency 36

SHORT syndrome

type 2 diabetes mellitus

Mouse Phenotypes

decreased insulin secretion

decreased circulating glucose level

hypoglycemia

hyperglycemia

decreased circulating insulin level

increased circulating insulin level

increased circulating insulin-like growth factor I level

chylous ascites

abnormal glucose homeostasis

impaired glucose tolerance

improved glucose tolerance

increased insulin sensitivity

insulin resistance

abnormal lipid homeostasis

decreased triglyceride level

Availability

Mouse Genotype

Pik3r1^tm1Dfr/Pik3r1^tm1Dfr

Pik3r1^tm1Khn/Pik3r1^tm1Khn

Pik3r1^tm1Tka/Pik3r1^tm1Tka

Pik3r1^tm2Dfr/Pik3r1^tm2Dfr

Pik3r1^tm1.1Geno/Pik3r1⁺

Pik3r1^tm2Dfr/Pik3r1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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