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Gene Ontology Browser
Term Detail
GO term:phosphatidylinositol 3-kinase complex, class IA
Synonym: 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
Synonym: 1-phosphatidylinositol-4-phosphate kinase, class IA complex
Synonym: class IA PI3K complex
Synonym: phosphoinositide 3-kinase complex, class IA
GO id:GO:0005943
Alternate id: GO:0035030
Definition:A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-acatalytic complex
                                        is-atransferase complex
                                                is-aphosphatidylinositol 3-kinase complex
                                                        is-aphosphatidylinositol 3-kinase complex, class I
                                                                is-aphosphatidylinositol 3-kinase complex, class IA [GO:0005943] (1 genes, 2 annotations)
                                                                is-aphosphatidylinositol 3-kinase complex, class IB


Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-aextrinsic component of membrane
                                        part-ofphosphatidylinositol 3-kinase complex
                                                is-aphosphatidylinositol 3-kinase complex, class I
                                                        is-aphosphatidylinositol 3-kinase complex, class IA [GO:0005943] (1 genes, 2 annotations)
                                                        is-aphosphatidylinositol 3-kinase complex, class IB


Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-aphosphatidylinositol 3-kinase complex
                                        is-aphosphatidylinositol 3-kinase complex, class I
                                                is-aphosphatidylinositol 3-kinase complex, class IA [GO:0005943] (1 genes, 2 annotations)
                                                is-aphosphatidylinositol 3-kinase complex, class IB


Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-aextrinsic component of membrane
                                part-ofphosphatidylinositol 3-kinase complex
                                        is-aphosphatidylinositol 3-kinase complex, class I
                                                is-aphosphatidylinositol 3-kinase complex, class IA [GO:0005943] (1 genes, 2 annotations)
                                                is-aphosphatidylinositol 3-kinase complex, class IB


Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-aphosphatidylinositol 3-kinase complex
                                is-aphosphatidylinositol 3-kinase complex, class I
                                        is-aphosphatidylinositol 3-kinase complex, class IA [GO:0005943] (1 genes, 2 annotations)
                                        is-aphosphatidylinositol 3-kinase complex, class IB


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory