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Gene Ontology Browser
Term Detail
GO term:1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
Synonym: 1-phosphatidylinositol-4-phosphate kinase, class IA complex
Synonym: class IA PI3K complex
Synonym: phosphoinositide 3-kinase complex, class IA
GO id:GO:0005943
Definition:A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.
Number of paths to term: 17

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasm
                                                        part-ofcytoplasmic part
                                                                is-acytosol
                                                                        part-ofcytosolic part
                                                                                is-aphosphatidylinositol 3-kinase complex
                                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                                        is-aphosphatidylinositol 3-kinase complex I
                                                                                        is-aphosphatidylinositol 3-kinase complex II
                                                                                        is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasm
                                                        part-ofcytoplasmic part
                                                                is-acytosolic part
                                                                        is-aphosphatidylinositol 3-kinase complex
                                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                                is-aphosphatidylinositol 3-kinase complex I
                                                                                is-aphosphatidylinositol 3-kinase complex II
                                                                                is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasmic part
                                                        is-acytosol
                                                                part-ofcytosolic part
                                                                        is-aphosphatidylinositol 3-kinase complex
                                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                                is-aphosphatidylinositol 3-kinase complex I
                                                                                is-aphosphatidylinositol 3-kinase complex II
                                                                                is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasmic part
                                                        is-acytosolic part
                                                                is-aphosphatidylinositol 3-kinase complex
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                        is-aphosphatidylinositol 3-kinase complex I
                                                                        is-aphosphatidylinositol 3-kinase complex II
                                                                        is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-acytosol
                                                                part-ofcytosolic part
                                                                        is-aphosphatidylinositol 3-kinase complex
                                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                                is-aphosphatidylinositol 3-kinase complex I
                                                                                is-aphosphatidylinositol 3-kinase complex II
                                                                                is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-acytosolic part
                                                                is-aphosphatidylinositol 3-kinase complex
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                        is-aphosphatidylinositol 3-kinase complex I
                                                                        is-aphosphatidylinositol 3-kinase complex II
                                                                        is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasmic part
                                                is-acytosol
                                                        part-ofcytosolic part
                                                                is-aphosphatidylinositol 3-kinase complex
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                        is-aphosphatidylinositol 3-kinase complex I
                                                                        is-aphosphatidylinositol 3-kinase complex II
                                                                        is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasmic part
                                                is-acytosolic part
                                                        is-aphosphatidylinositol 3-kinase complex
                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                is-aphosphatidylinositol 3-kinase complex I
                                                                is-aphosphatidylinositol 3-kinase complex II
                                                                is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-acytosol
                                                                part-ofcytosolic part
                                                                        is-aphosphatidylinositol 3-kinase complex
                                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                                is-aphosphatidylinositol 3-kinase complex I
                                                                                is-aphosphatidylinositol 3-kinase complex II
                                                                                is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-acytosolic part
                                                                is-aphosphatidylinositol 3-kinase complex
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                        is-aphosphatidylinositol 3-kinase complex I
                                                                        is-aphosphatidylinositol 3-kinase complex II
                                                                        is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasmic part
                                                is-acytosol
                                                        part-ofcytosolic part
                                                                is-aphosphatidylinositol 3-kinase complex
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                        is-aphosphatidylinositol 3-kinase complex I
                                                                        is-aphosphatidylinositol 3-kinase complex II
                                                                        is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasmic part
                                                is-acytosolic part
                                                        is-aphosphatidylinositol 3-kinase complex
                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                is-aphosphatidylinositol 3-kinase complex I
                                                                is-aphosphatidylinositol 3-kinase complex II
                                                                is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasm
                                        part-ofcytoplasmic part
                                                is-acytosol
                                                        part-ofcytosolic part
                                                                is-aphosphatidylinositol 3-kinase complex
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                        is-aphosphatidylinositol 3-kinase complex I
                                                                        is-aphosphatidylinositol 3-kinase complex II
                                                                        is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasm
                                        part-ofcytoplasmic part
                                                is-acytosolic part
                                                        is-aphosphatidylinositol 3-kinase complex
                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                is-aphosphatidylinositol 3-kinase complex I
                                                                is-aphosphatidylinositol 3-kinase complex II
                                                                is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasmic part
                                        is-acytosol
                                                part-ofcytosolic part
                                                        is-aphosphatidylinositol 3-kinase complex
                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                                is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                                is-aphosphatidylinositol 3-kinase complex I
                                                                is-aphosphatidylinositol 3-kinase complex II
                                                                is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasmic part
                                        is-acytosolic part
                                                is-aphosphatidylinositol 3-kinase complex
                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                        is-aphosphatidylinositol 3-kinase complex I
                                                        is-aphosphatidylinositol 3-kinase complex II
                                                        is-aphosphatidylinositol 3-kinase complex, class III


Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-acatalytic complex
                                        is-atransferase complex
                                                is-aphosphatidylinositol 3-kinase complex
                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex [GO:0005943] (1 genes, 1 annotations)
                                                        is-a1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
                                                        is-aphosphatidylinositol 3-kinase complex I
                                                        is-aphosphatidylinositol 3-kinase complex II
                                                        is-aphosphatidylinositol 3-kinase complex, class III


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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory