About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:extrinsic apoptotic signaling pathway via death domain receptors
Synonym: death receptor-mediated apoptosis
Synonym: induction of apoptosis via death domain receptors
Synonym: induction of apoptosis via death receptors
GO id:GO:0008625
Definition:A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
CommentsGene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
Number of paths to term: 21

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aapoptotic signaling pathway
                                                        is-aextrinsic apoptotic signaling pathway
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        is-aTRAIL-activated apoptotic signaling pathway +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aextrinsic apoptotic signaling pathway
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        is-aTRAIL-activated apoptotic signaling pathway +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        is-aextrinsic apoptotic signaling pathway
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        is-aTRAIL-activated apoptotic signaling pathway +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aextrinsic apoptotic signaling pathway
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        is-aTRAIL-activated apoptotic signaling pathway +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                is-aextrinsic apoptotic signaling pathway
                                                                        is-aB cell receptor apoptotic signaling pathway
                                                                        part-ofdeath-inducing signaling complex assembly +
                                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                is-aextrinsic apoptotic signaling pathway
                                                                        is-aB cell receptor apoptotic signaling pathway
                                                                        part-ofdeath-inducing signaling complex assembly +
                                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aextrinsic apoptotic signaling pathway
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        is-aextrinsic apoptotic signaling pathway
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        is-aTRAIL-activated apoptotic signaling pathway +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aextrinsic apoptotic signaling pathway
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                        is-aTRAIL-activated apoptotic signaling pathway +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                is-aextrinsic apoptotic signaling pathway
                                                                        is-aB cell receptor apoptotic signaling pathway
                                                                        part-ofdeath-inducing signaling complex assembly +
                                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (68 genes, 87 annotations)
                                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
                                                                                regulatesregulation of extrinsic apoptotic signaling pathway via death domain receptors +
                                                                                is-aTRAIL-activated apoptotic signaling pathway +
                                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory