| GO term: | extrinsic apoptotic signaling pathway via death domain receptors |
| Synonym: | death receptor-mediated apoptosis |
| Synonym: | induction of apoptosis via death domain receptors |
| Synonym: | induction of apoptosis via death receptors |
| GO id: | GO:0008625 |
| Definition: | A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. |
| Number of paths to term: | 23 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processcellular processregulation of cellular processsignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processcellular processregulation of cellular processsignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processcellular processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processcellular processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processresponse to stimuluscellular response to stimulussignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processresponse to stimuluscellular response to stimulussignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsignalingsingle organism signalingsignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsignalingsingle organism signalingsignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsingle-organism processsingle organism signalingsignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsingle-organism processsingle organism signalingsignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaybiological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayextrinsic apoptotic signaling pathwaydeath-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625] (20 genes, 26 annotations)negative regulation of extrinsic apoptotic signaling pathway via death domain receptorspositive regulation of extrinsic apoptotic signaling pathway via death domain receptorsregulation of extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
||
|
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. |
last database update 05/22/2013 MGI 5.13 |
|
|
|
||
Analysis Tools